INT127133

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SUCLG2) small molecule metabolic process (SUCLG2) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) ligase activity (SUCLG2)
OPRM1 (Homo sapiens)
SUCLG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
opiate 2 92.24 High High
addiction 2 90.72 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 3 75.00 Quite High
Opiate Addiction 1 62.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, sustained activation of the MOP receptor by morphine in sc2 cells seems to promote proteasomal degradation of Gbeta to sensitize adenylate cyclase.
Positive_regulation (activation) of MOP receptor Spec (seems) Positive_regulation (promote) of Protein_catabolism (degradation) of Gbeta associated with opioid and morphine
1) Confidence 0.20 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15901846 Disease Relevance 0.20 Pain Relevance 1.10

General Comments

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