INT127137

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.08
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TECR) endoplasmic reticulum (TECR) cytoplasm (TECR)
Anatomy Link Frequency
plasma 1
SH-SY5Y 1
TECR (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 12 99.82 Very High Very High Very High
Morphine 27 99.24 Very High Very High Very High
opiate 6 91.04 High High
addiction 6 90.76 High High
Inflammatory mediators 3 56.16 Quite High
cytokine 5 47.84 Quite Low
Inflammation 9 21.68 Low Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 9 99.68 Very High Very High Very High
Acute Renal Failure 83 98.94 Very High Very High Very High
Burns 74 98.72 Very High Very High Very High
Opiate Addiction 3 91.04 High High
Proteinuria 33 86.96 High High
Glycosuria 1 82.76 Quite High
Congenital Anomalies 1 77.84 Quite High
Apoptosis 41 75.76 Quite High
Injury 15 70.32 Quite High
INFLAMMATION 13 56.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial aim of this study was to identify protein changes associated with long-term morphine treatment in a recombinant human neuroblastoma SH-SY5Y clone (sc2) stably overexpressing the human mu-opioid (MOP) receptor.
Gene_expression (overexpressing) of sc2 in SH-SY5Y associated with neuroblastoma, opioid and morphine
1) Confidence 0.30 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15901846 Disease Relevance 0.32 Pain Relevance 0.87
In MOP receptor-overexpressing sc2 cells, short-term morphine exposure was found to be much more potent and efficacious in inhibiting forskolin-elicited production of cAMP, and long-term morphine exposure was shown to induce a substantially higher degree of opiate dependence, as reflected by adenylate cyclase sensitization, than it did in wild-type neuroblastoma cells.
Gene_expression (overexpressing) of sc2 associated with addiction, neuroblastoma, opiate, opioid and morphine
2) Confidence 0.24 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15901846 Disease Relevance 0.35 Pain Relevance 0.92
In MOP receptor-overexpressing sc2 cells, short-term morphine exposure was found to be much more potent and efficacious in inhibiting forskolin-elicited production of cAMP, and long-term morphine exposure was shown to induce a substantially higher degree of opiate dependence, as reflected by adenylate cyclase sensitization, than it did in wild-type neuroblastoma cells.
Gene_expression (-) of sc2 associated with addiction, neuroblastoma, opiate, opioid and morphine
3) Confidence 0.24 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15901846 Disease Relevance 0.35 Pain Relevance 0.92
After challenge of tubular cells with burns septic ARF group plasma, we observed a marked decrease of ZO-1 expression with a simultaneous alteration of TER.
Gene_expression (expression) of TER in plasma associated with acute renal failure and burns
4) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.06 Pain Relevance 0.03

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