INT12717

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 2010
Negated 2
Speculated 6
Reported most in Abstract
Documents 85
Total Number 94
Disease Relevance 12.49
Pain Relevance 54.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
brain 7
External 7
striatum 4
spinal cord 3
dorsal horn 3
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 119 100.00 Very High Very High Very High
antagonist 80 100.00 Very High Very High Very High
Immobilon 16 100.00 Very High Very High Very High
opioid receptor 100 99.84 Very High Very High Very High
Morphine 92 99.84 Very High Very High Very High
Dorsal horn 10 99.84 Very High Very High Very High
agonist 269 99.80 Very High Very High Very High
Spinal cord 41 99.66 Very High Very High Very High
Hippocampus 4 99.66 Very High Very High Very High
MU agonist 72 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 50 99.66 Very High Very High Very High
Hyperalgesia 1 98.96 Very High Very High Very High
Cognitive Disorder 22 98.84 Very High Very High Very High
Frailty 10 98.76 Very High Very High Very High
Toxicity 15 98.72 Very High Very High Very High
Newborn Drug Withdrawal Syndrome 4 98.40 Very High Very High Very High
Arthritis 5 98.04 Very High Very High Very High
Neuropathic Pain 14 97.96 Very High Very High Very High
Injury 9 97.00 Very High Very High Very High
Mental Disorders 63 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Signal transduction correlates of mu opioid agonist intrinsic efficacy: receptor-stimulated [35S]GTP gamma S binding in mMOR-CHO cells and rat thalamus.
GTP Binding (binding) of in thalamus associated with mu agonist, enkephalin and thalamus
1) Confidence 0.47 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9580589 Disease Relevance 0 Pain Relevance 0.87
Repeated treatment with antidepressants differentially alters 5-HT1A agonist-stimulated [35S]GTP gamma S binding in rat brain regions.
GTP Binding (binding) of in brain associated with antidepressant and agonist
2) Confidence 0.47 Published 2002 Journal Neuropharmacology Section Title Doc Link 12128004 Disease Relevance 0.26 Pain Relevance 0.46
Agonist stimulation of [35S]GTP gamma S binding was stereoselective, naltrexone-reversible, and pertussis toxin-sensitive.
GTP Binding (binding) of associated with bordatella infection and agonist
3) Confidence 0.47 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819494 Disease Relevance 0.24 Pain Relevance 1.03
The rank order of the stimulation of [35S]GTP gamma S binding was etonitazene = sufentanil = DAMGO = PLO17 = fentanyl > morphine > profadol > meperidine > butorphanol = nalbuphine = pentazocine > cyclazocine = nalorphine > levallorphan > naltrexone.
GTP Binding (binding) of associated with fortral, nalbuphine, butorphanol and morphine
4) Confidence 0.47 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819494 Disease Relevance 0.23 Pain Relevance 1.18
The EC50 for DAMGO was 30 nM, similar to its potency to inhibit cAMP accumulation and to increase [gamma-35S]GTP binding.
GTP Binding (binding) of associated with potency
5) Confidence 0.47 Published 1999 Journal Neuroreport Section Abstract Doc Link 10439458 Disease Relevance 0 Pain Relevance 0.95
Comparison of the potency of these compounds with their potencies in an in vitro functional model, agonist-induced [35S]GTP gamma S binding, suggests that blockade of dural extravasation was consistent with an action at rat 5-HT1D receptors, but activity at another, unknown, "extravasation receptor" could also be involved.
GTP Binding (binding) of associated with agonist and potency
6) Confidence 0.47 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225277 Disease Relevance 0.61 Pain Relevance 0.61
Effects of intracerebroventricular administration of beta-funaltrexamine on DAMGO-stimulated [35S]GTP-gamma-S binding in rat brain sections.
GTP Binding (binding) of in brain associated with enkephalin and intracerebroventricular
7) Confidence 0.47 Published 1997 Journal Synapse Section Title Doc Link 9329153 Disease Relevance 0 Pain Relevance 0.55
DAMGO stimulated [35S]GTP-gamma-S binding with an anatomical specificity consistent with the localization of mu opioid receptors.
GTP Binding (binding) of associated with mu opioid receptor
8) Confidence 0.47 Published 1997 Journal Synapse Section Abstract Doc Link 9329153 Disease Relevance 0 Pain Relevance 0.55
Stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTP gamma S) binding to membranes was used as a measure of G protein activation.
GTP Binding (binding) of
9) Confidence 0.47 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9655870 Disease Relevance 0.08 Pain Relevance 0.87
The potency and maximal stimulation of [35S]GTP gamma S binding by various agonists was measured in the presence of excess GDP and compared with receptor binding affinity under identical assay conditions.
GTP Binding (binding) of associated with agonist and potency
10) Confidence 0.47 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580589 Disease Relevance 0 Pain Relevance 0.58
Saturation analysis of agonist-stimulated [35S]GTP gamma S binding revealed that full agonists produced both a higher Bmax and apparent affinity of [35S]GTP gamma S binding than partial agonists.
GTP Spec (partial) Binding (binding) of associated with agonist
11) Confidence 0.47 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580589 Disease Relevance 0 Pain Relevance 0.89
Saturation analysis of agonist-stimulated [35S]GTP gamma S binding revealed that full agonists produced both a higher Bmax and apparent affinity of [35S]GTP gamma S binding than partial agonists.
GTP Binding (binding) of associated with agonist
12) Confidence 0.47 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580589 Disease Relevance 0 Pain Relevance 0.90
In membrane assays, with 20 microM GDP, ORL1 peptide stimulated [35S]GTP gamma S binding by approximately two-fold with an ED50 value of 20 nM.
GTP Binding (binding) of
13) Confidence 0.47 Published 1996 Journal Neuroreport Section Abstract Doc Link 8733732 Disease Relevance 0 Pain Relevance 0.29
Seven days of chronic sufentanil treatment developed antinociceptive tolerance associated with a reduction in mu-agonist-induced [35S]GTP gamma S binding, mu-agonist-induced adenylyl cyclase inhibition, and co-precipitation of G alpha o, G alpha i2 G alpha z and G alpha q11 subunits with mu-opioid receptors.
GTP Binding (binding) of associated with mu opioid receptor, agonist, tolerance and antinociceptive
14) Confidence 0.47 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18384820 Disease Relevance 0.17 Pain Relevance 1.06
Mu and delta opioid-stimulated [35S]GTP gamma S binding in brain and spinal cord of polyarthritic rats.
GTP Binding (binding) of in brain associated with opioid and spinal cord
15) Confidence 0.47 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15507218 Disease Relevance 0.18 Pain Relevance 0.80
In sense-treated control cells, DAMGO-stimulated [35S]GTP-gamma-S binding by increasing the B(max) of the high-affinity site.
GTP Binding (binding) of
16) Confidence 0.47 Published 2004 Journal Synapse Section Abstract Doc Link 15065220 Disease Relevance 0.22 Pain Relevance 0.76
Estrogen modulation of mu-opioid receptor-stimulated [35S]-GTP-gamma-S binding in female rat brain visualized by in vitro autoradiography.
GTP Binding (binding) of in brain associated with opioid receptor
17) Confidence 0.47 Published 2002 Journal Neuroendocrinology Section Title Doc Link 12411740 Disease Relevance 0.15 Pain Relevance 0.40
Binding surface analysis was used to characterize the interactions of ET, Gpp(Np)H and GTP-gamma-S with sites labeled by [(35)S]GTP-gamma-S.
GTP Binding (interactions) of associated with immobilon
18) Confidence 0.36 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10704787 Disease Relevance 0 Pain Relevance 0.74
The addition of purified GTP-binding proteins caused an increase in the binding to the membranes pretreated with 50 microM NEM, but did not increase [3H]-clonidine binding in membranes treated with 500 microM NEM.
GTP Binding (binding) of associated with clonidine
19) Confidence 0.36 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2824697 Disease Relevance 0 Pain Relevance 0.44
The guanine nucleotide analogue, 5'-p-fluorosulphonylbenzoyl guanosine (FSBG), can react covalently with GTP-binding proteins (G proteins).
GTP Binding (react) of
20) Confidence 0.36 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152798 Disease Relevance 0 Pain Relevance 0.41

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