INT127175

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.11
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 19 100.00 Very High Very High Very High
aspirin 15 87.48 High High
IPN 2 83.40 Quite High
Analgesic 3 79.04 Quite High
Pain 3 71.88 Quite High
cINOD 13 43.36 Quite Low
COX2 2 25.00 Low Low
agonist 7 8.60 Low Low
dorsal root ganglion 19 5.00 Very Low Very Low Very Low
qutenza 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 23 100.00 Very High Very High Very High
Cancer 2 99.80 Very High Very High Very High
Necrosis 2 99.56 Very High Very High Very High
Inflammatory Pain 2 83.40 Quite High
Pressure And Volume Under Development 1 76.92 Quite High
Nociception 30 75.52 Quite High
Pain 2 71.88 Quite High
Diabetes Mellitus 1 66.00 Quite High
Cardiovascular Disease 1 65.48 Quite High
Gastrointestinal Neoplasms 1 64.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SA was not expected to have any effect in this assay because it is known not to affect PGHS-1 or 2 activity [31] except in intact cells [30], possibly by suppressing PGHS-2 transcription in response to exogenous stimuli [32].
Negative_regulation (suppressing) of Transcription (transcription) of PGHS-2
1) Confidence 0.47 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1592475 Disease Relevance 0 Pain Relevance 0.08
Consistent with these observations, MEIO potently inhibited the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Negative_regulation (inhibited) of Transcription (expressions) of cyclooxygenase-2
2) Confidence 0.10 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15905055 Disease Relevance 0.99 Pain Relevance 0.23
For example, 15d-PGJ2 represses the transcription of a number of pro-inflammatory factors including inducible nitric oxide synthase, cyclooxygenase-2 and tumor necrosis factor-?
Negative_regulation (represses) of Transcription (transcription) of cyclooxygenase-2 associated with necrosis, inflammation and cancer
3) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2515828 Disease Relevance 1.12 Pain Relevance 0.38

General Comments

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