INT127182

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 3.09
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (L1cam) endosome (L1cam) cell adhesion (L1cam)
plasma membrane (L1cam)
Anatomy Link Frequency
neuronal 4
brain 1
L1cam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 24 99.40 Very High Very High Very High
depression 6 96.72 Very High Very High Very High
Desipramine 6 96.52 Very High Very High Very High
fluoxetine 6 94.16 High High
Disease Link Frequency Relevance Heat
Stress 36 99.82 Very High Very High Very High
Depression 6 96.72 Very High Very High Very High
Neuroblastoma 6 94.56 High High
Adhesions 6 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity.
Regulation (modulate) of CAM-L1 in neuronal associated with stress and antidepressant
1) Confidence 0.54 Published 2005 Journal Neurobiol. Dis. Section Title Doc Link 15905095 Disease Relevance 0.46 Pain Relevance 0.12
In the present study, we hypothesized that the regulation of CAM-L1, laminin, and CREB/pCREB by NE could mediate processes of plasticity in the mode of action of antidepressants, as well as in the long-term effects of stress, in rats, given the association of both with NE alterations and neuronal plasticity.
Regulation (regulation) of CAM-L1 in neuronal associated with stress and antidepressant
2) Confidence 0.39 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15905095 Disease Relevance 0.47 Pain Relevance 0.12
In the present study, we hypothesized that the regulation of CAM-L1, laminin, and CREB/pCREB by NE could mediate processes of plasticity in the mode of action of antidepressants, as well as in the long-term effects of stress, in rats, given the association of both with NE alterations and neuronal plasticity.
Regulation (regulation) of CAM-L1 in neuronal associated with stress and antidepressant
3) Confidence 0.39 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15905095 Disease Relevance 0.47 Pain Relevance 0.12
Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity.
Regulation (modulate) of CAM-L1 in neuronal associated with stress and antidepressant
4) Confidence 0.39 Published 2005 Journal Neurobiol. Dis. Section Title Doc Link 15905095 Disease Relevance 0.46 Pain Relevance 0.12
We found brain region-specific alterations in mRNA and protein levels of CAM-L1, laminin, and pCREB in rats chronically treated with the noradrenergic antidepressant desipramine and, to a lesser extent, in those treated with fluoxetine.
Regulation (alterations) of CAM-L1 in brain associated with desipramine, antidepressant and fluoxetine
5) Confidence 0.24 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15905095 Disease Relevance 0.57 Pain Relevance 0.35
Our findings suggest that noradrenergic-regulated plasticity genes such as CAM-L1, laminin, and CREB play an important role both in stress and in the treatment of depression.
Regulation (regulated) of CAM-L1 associated with stress and depression
6) Confidence 0.24 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15905095 Disease Relevance 0.66 Pain Relevance 0.34

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