INT127202

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.70
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mcf2l) intracellular (Mcf2l) cytoplasm (Mcf2l)
Anatomy Link Frequency
visceral 1
DBS 1
Mcf2l (Mus musculus)
Pain Link Frequency Relevance Heat
deep brain stimulation 35 100.00 Very High Very High Very High
medulla 18 100.00 Very High Very High Very High
fibrosis 30 99.36 Very High Very High Very High
Locus ceruleus 2 99.36 Very High Very High Very High
parabrachial 2 98.28 Very High Very High Very High
insula 6 93.92 High High
spastic colon 12 91.32 High High
anesthesia 7 90.68 High High
isoflurane 5 90.56 High High
amygdala 2 87.60 High High
Disease Link Frequency Relevance Heat
Duodenal Ulcer 25 99.80 Very High Very High Very High
Cystic Fibrosis 30 99.36 Very High Very High Very High
Cognitive Disorder 4 98.68 Very High Very High Very High
Ulcers 5 96.76 Very High Very High Very High
Injury 5 95.52 Very High Very High Very High
Dysarthria 1 94.40 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 91.32 High High
Disease 15 89.92 High High
Functional Bowel Disorder 4 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deficits in preparatory inhibition of DBS, including the locus ceruleus complex and parabrachial nuclei, may interfere with descending corticolimbic inhibition and contribute to enhanced brain responsiveness and perceptual sensitivity to visceral stimuli in IBS.
Negative_regulation (inhibition) of DBS in visceral associated with medulla, spastic colon, locus ceruleus and parabrachial
1) Confidence 0.50 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18184777 Disease Relevance 0.17 Pain Relevance 1.01
By changing the stimulation parameters or the active contacts, the effect of DBS was not diminished.


Neg (not) Negative_regulation (diminished) of DBS associated with deep brain stimulation
2) Confidence 0.37 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1847528 Disease Relevance 0.69 Pain Relevance 0.19
Self-rated measures of negative affect during scanning were higher in patients than controls (p < 0.001), and the anticipatory BOLD decreases in DBS were inversely correlated with these ratings.
Negative_regulation (decreases) of DBS in DBS associated with medulla
3) Confidence 0.37 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18184777 Disease Relevance 0.57 Pain Relevance 1.21
Although impaired DBS is observed in CF mutant mice and in CF patients, which would predict increased ulcer susceptibility, duodenal injury is rarely observed in CF patients and is reduced in CF mutant mice.
Negative_regulation (impaired) of DBS associated with fibrosis, injury and ulcers
4) Confidence 0.14 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.96 Pain Relevance 0.37
Acid-induced DBS was abolished at 1 and 3 h and was reduced 24 h after treatment with CFTR(inh)-172, although basal DBS was increased at 24 h.
Negative_regulation (reduced) of DBS
5) Confidence 0.14 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.92 Pain Relevance 0.32
To further test this hypothesis, we examined the effect of a novel, potent, and highly selective CFTR inhibitor, CFTR(inh)-172, on DBS and duodenal ulceration in rats.
Negative_regulation (inhibitor) of DBS associated with duodenal ulcer
6) Confidence 0.14 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.94 Pain Relevance 0.39
Superfusion of CFTR(inh)-172 (0.1-10 microM) over the duodenal mucosa had no effect on basal DBS but at 10 microM inhibited acid-induced DBS, suggesting that its effect was limited to CFTR activation.
Negative_regulation (inhibited) of DBS
7) Confidence 0.14 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.94 Pain Relevance 0.34
Acid-induced DBS was abolished at 1 and 3 h and was reduced 24 h after treatment with CFTR(inh)-172, although basal DBS was increased at 24 h.
Negative_regulation (abolished) of DBS
8) Confidence 0.14 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.91 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox