INT127203

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 9.84
Pain Relevance 7.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mcf2l) intracellular (Mcf2l) cytoplasm (Mcf2l)
Anatomy Link Frequency
brain 3
dorsal 1
epithelial cells 1
lobe 1
insula 1
Mcf2l (Mus musculus)
Pain Link Frequency Relevance Heat
deep brain stimulation 122 100.00 Very High Very High Very High
medulla 18 100.00 Very High Very High Very High
insula 6 100.00 Very High Very High Very High
phantom limb 2 99.80 Very High Very High Very High
Pain 25 99.28 Very High Very High Very High
headache 4 97.96 Very High Very High Very High
Thalamus 1 97.56 Very High Very High Very High
painful pain 1 96.48 Very High Very High Very High
imagery 15 93.68 High High
magnetoencephalography 4 93.04 High High
Disease Link Frequency Relevance Heat
Pain 27 99.28 Very High Very High Very High
Duodenal Ulcer 20 99.24 Very High Very High Very High
Affective Disorder 9 99.08 Very High Very High Very High
Headache 3 97.96 Very High Very High Very High
Epilepsy 13 97.56 Very High Very High Very High
Neuropathic Pain 4 97.12 Very High Very High Very High
Nociception 2 96.48 Very High Very High Very High
Disease 30 95.84 Very High Very High Very High
Dystonia 210 95.12 Very High Very High Very High
Movement Disorders 13 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two main themes will advance DBS significantly in the next five years: closed-loop DBS, that is, feedback from brain electrical activity to direct the stimulation; and computational analysis (CA)--electrophysiological modeling to enhance DBS.
Positive_regulation (advance) of DBS in brain
1) Confidence 0.43 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20633126 Disease Relevance 0.67 Pain Relevance 0.25
Two main themes will advance DBS significantly in the next five years: closed-loop DBS, that is, feedback from brain electrical activity to direct the stimulation; and computational analysis (CA)--electrophysiological modeling to enhance DBS.
Positive_regulation (enhance) of DBS in brain
2) Confidence 0.43 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20633126 Disease Relevance 0.74 Pain Relevance 0.26
Two main themes will advance DBS significantly in the next five years: closed-loop DBS, that is, feedback from brain electrical activity to direct the stimulation; and computational analysis (CA)--electrophysiological modeling to enhance DBS.
Positive_regulation (advance) of DBS in brain
3) Confidence 0.43 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20633126 Disease Relevance 0.73 Pain Relevance 0.26
During subsequent distention, both groups showed activity increases in insula, dorsal ACC, and DBS and decreases in the infragenual ACC.
Positive_regulation (increases) of DBS in insula associated with medulla and insula
4) Confidence 0.40 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18184777 Disease Relevance 0.55 Pain Relevance 1.25
This work highlights several factors felt to increase DBS hardware complications.
Positive_regulation (increase) of DBS associated with deep brain stimulation
5) Confidence 0.40 Published 2005 Journal Can J Neurol Sci Section Abstract Doc Link 16018154 Disease Relevance 0.44 Pain Relevance 0.30
We were able to record activity over the occipital lobe of a patient using DBS for phantom limb pain during presentation of a visual stimulus.
Positive_regulation (using) of DBS in lobe associated with pain, phantom limb and deep brain stimulation
6) Confidence 0.22 Published 2009 Journal J Clin Neurosci Section Abstract Doc Link 19019684 Disease Relevance 0.44 Pain Relevance 1.18
The stimulation of these sites through MCS (motor cortex stimulation) and DBS (deep brain stimulation) has proven effective for treating a number of neuropathic and nociceptive pain states that are not responsive or amenable to other therapies or types of neurostimulation.
Positive_regulation (stimulation) of DBS in cortex associated with deep brain stimulation, neuropathic pain and painful pain
7) Confidence 0.20 Published 2010 Journal Pain Physician Section Abstract Doc Link 20309382 Disease Relevance 0.53 Pain Relevance 0.47
The low complication rate, the reversibility of the procedure and the available image guided surgery tools will further increase the therapeutic applications of DBS.
Positive_regulation (increase) of DBS
8) Confidence 0.20 Published 2006 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 17370756 Disease Relevance 0.45 Pain Relevance 0.17
Acid-induced DBS was abolished at 1 and 3 h and was reduced 24 h after treatment with CFTR(inh)-172, although basal DBS was increased at 24 h.
Positive_regulation (induced) of DBS
9) Confidence 0.15 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.91 Pain Relevance 0.32
Acid-induced DBS was abolished at 1 and 3 h and was reduced 24 h after treatment with CFTR(inh)-172, although basal DBS was increased at 24 h.
Positive_regulation (increased) of DBS
10) Confidence 0.15 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.89 Pain Relevance 0.30
Superfusion of CFTR(inh)-172 (0.1-10 microM) over the duodenal mucosa had no effect on basal DBS but at 10 microM inhibited acid-induced DBS, suggesting that its effect was limited to CFTR activation.
Positive_regulation (induced) of DBS
11) Confidence 0.15 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.93 Pain Relevance 0.34
CFTR inhibition reduces acid-induced DBS but also prevents duodenal ulcer formation, supporting our hypothesis that intracellular HCO(3)(-) may be an important protective mechanism for duodenal epithelial cells.
Positive_regulation (induced) of DBS in epithelial cells associated with duodenal ulcer
12) Confidence 0.15 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.56 Pain Relevance 0.16
During subsequent distention, both groups showed activity increases in insula, dorsal ACC, and DBS and decreases in the infragenual ACC.
Positive_regulation (increases) of DBS in dorsal associated with medulla and insula
13) Confidence 0.14 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18184777 Disease Relevance 0.55 Pain Relevance 1.25
For this purpose, we are maintaining a prospective database of patients with NBIA undergoing DBS.
Positive_regulation (undergoing) of DBS associated with deep brain stimulation
14) Confidence 0.01 Published 2010 Journal Brain Section Body Doc Link PMC2842517 Disease Relevance 0.39 Pain Relevance 0.18
Neither this study nor the Castelneau et al. (2005) study had a control group of patients with NBIA who did not undergo GPi-DBS.
Neg (not) Positive_regulation (undergo) of DBS associated with deep brain stimulation
15) Confidence 0.01 Published 2010 Journal Brain Section Body Doc Link PMC2842517 Disease Relevance 0.46 Pain Relevance 0.35

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