INT127206

Context Info Confidence 0.16 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.62 Pain Relevance 0.16

cytoplasm (Cftr, Mcf2l) intracellular (Mcf2l) enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr) ATPase activity (Cftr)

Anatomy Link Frequency epithelial cells 3 Cftr (Rattus norvegicus) Mcf2l (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 70.84 isoflurane 1 70.40 fibrosis 6 54.40

Disease Link Frequency Relevance Heat Duodenal Ulcer 5 99.24 Cystic Fibrosis 6 54.40 Injury 1 52.20 Ulcers 1 50.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CFTR inhibition reduces acid-induced DBS but also prevents duodenal ulcer formation, supporting our hypothesis that intracellular HCO(3)(-) may be an important protective mechanism for duodenal epithelial cells.

Negative_regulation (inhibition) of CFTR in epithelial cells Negative_regulation (reduces) of Positive_regulation (induced) of DBS in epithelial cells associated with duodenal ulcer

1) Confidence 0.16 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.62 Pain Relevance 0.16

General Comments

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