INT127244

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.29
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (APOL1) transport (APOL1) extracellular space (APOL1)
extracellular region (APOL1)
APOL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 5 92.56 High High
Inflammatory response 16 13.76 Low Low
cytokine 56 5.00 Very Low Very Low Very Low
Inflammation 36 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
pruritus 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sclerosis 6 100.00 Very High Very High Very High
Disease 107 99.52 Very High Very High Very High
Albuminuria 2 98.00 Very High Very High Very High
African Trypanosomiasis 88 97.20 Very High Very High Very High
Targeted Disruption 12 93.12 High High
Infection 212 92.92 High High
Headache 5 92.56 High High
Tinnitus 1 92.04 High High
Fatigue 1 91.64 High High
Renal Disease 2 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APOL1 is only found in the sera from humans and gorilla which have the trypanolytic capacity but not in the chimpanzee serum which lacks the trypanolytic potential [89].
APOL1 Binding (found) of
1) Confidence 0.33 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.34 Pain Relevance 0
In case of T. rhodesiense the resistance to the trypanolytic capacity of APOL-1 is due to the expression of serum resistance-associated (SRA) protein [94] which neutralizes APOL1 through the interaction with the C-terminal of this lipoprotein.
APOL1 Binding (interaction) of
2) Confidence 0.31 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.45 Pain Relevance 0
Deletion of the SRA interacting domain of APOL1 results in the generation of a new molecule, that is, Tr-APOL1 that is lytic to both NHS-sensitive as well as resistant T. rhodesiense.
APOL1 Binding (interacting) of
3) Confidence 0.31 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.39 Pain Relevance 0
Furthermore, it has been shown that the full length baboon APOL1 (which does not interact with SRA) is protective against both the animal-infective and human-infective T. rhodesiense in an experimental mouse model, and, as such, it has been suggested to create transgenic livestock that would be resistant to animal and human-infective trypanosomes, which is envisaged to result in the reduction of the livestock trypanosomiasis and zoonotic transmission of human infective trypanosomes [119].
APOL1 Neg (not) Binding (interact) of associated with targeted disruption and trypanosomiasis
4) Confidence 0.31 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.56 Pain Relevance 0
We conclude that FSGS and vascular changes may be an early morphologic finding in Fabry's disease, even in patients with subtle albuminuria.
FSGS Spec (finding) Binding (finding) of associated with sclerosis, disease and albuminuria
5) Confidence 0.28 Published 2005 Journal Clin. Nephrol. Section Abstract Doc Link 15909601 Disease Relevance 1.55 Pain Relevance 0.09

General Comments

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