INT12725

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Context Info
Confidence 0.68
First Reported 1991
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 66
Total Number 67
Disease Relevance 32.74
Pain Relevance 19.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
grey matter 3
neuronal 3
hippocampus CA1 2
plasma 1
brain 1
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 150 100.00 Very High Very High Very High
antagonist 23 99.98 Very High Very High Very High
opiate 2 99.98 Very High Very High Very High
Pain 41 99.92 Very High Very High Very High
Analgesic 33 99.92 Very High Very High Very High
narcan 21 99.92 Very High Very High Very High
ischemia 1466 99.84 Very High Very High Very High
Delta opioid receptors 30 99.84 Very High Very High Very High
Enkephalin 13 99.82 Very High Very High Very High
Hippocampus 307 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 516 99.84 Very High Very High Very High
Cv General 4 Under Development 935 99.76 Very High Very High Very High
Parkinson's Disease 22 99.64 Very High Very High Very High
Urological Neuroanatomy 28 99.60 Very High Very High Very High
Reperfusion Injury 104 99.48 Very High Very High Very High
Stress 509 99.44 Very High Very High Very High
Adenocarcinoma 207 99.36 Very High Very High Very High
Pain 42 99.22 Very High Very High Very High
Bordatella Infection 7 99.16 Very High Very High Very High
Death 441 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some representative sigma agonists, such as (+)-pentazocine, SA4503 and (+)-3-PPP, stimulated the GTPase activity in a concentration-dependent manner in ranges of 10 nM to 10 microM.
Positive_regulation (stimulated) of GTPase associated with fortral and agonist
1) Confidence 0.68 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9350852 Disease Relevance 0 Pain Relevance 0.34
NE-100, a representative antagonist, showed no effect at concentrations not more than 100 nM, while it did stimulate GTPase activity at 1 and 10 microM.
Positive_regulation (stimulate) of GTPase associated with antagonist
2) Confidence 0.68 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9350852 Disease Relevance 0 Pain Relevance 0.40
G-receptor antagonists increased the activating effect of mastoparan on low Km GTPase of mouse PAG.
Positive_regulation (increased) of GTPase associated with antagonist, urological neuroanatomy and enkephalin
3) Confidence 0.63 Published 1995 Journal Cell. Signal. Section Title Doc Link 7794687 Disease Relevance 0.19 Pain Relevance 0.75
At delta1 receptors, DPDPE fully expressed its activation of GTPase.
Positive_regulation (activation) of GTPase
4) Confidence 0.51 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9215703 Disease Relevance 0.29 Pain Relevance 1.13
The blockade of G(i2)alpha subunits by specific antibodies impaired the activation of G alpha-related GTPase by all opioids.
Positive_regulation (activation) of GTPase associated with opioid
5) Confidence 0.51 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9215703 Disease Relevance 0.29 Pain Relevance 1.20
Supernatant from the cells pretreated with NS-398 moderately inhibited activation of RhoA-GTPase (Figure 10G) suggesting that PGE2 secretion might not be involved in the stimulation of RhoA in HMVEC-d cell adherence.
Positive_regulation (activation) of GTPase in d cell
6) Confidence 0.49 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.44 Pain Relevance 0
Mastoparan activated in a concentration-dependent manner the low Km GTPase activity in P2 fractions from mouse periaquedultal grey matter (PAG).
Positive_regulation (activated) of GTPase in grey matter associated with urological neuroanatomy
7) Confidence 0.45 Published 1995 Journal Cell. Signal. Section Abstract Doc Link 7794687 Disease Relevance 0.17 Pain Relevance 0.35
We observed 2.7, 3.8, 4.4 and 4.2- fold Rac1-GTPase activation upon plating cells in the presence of infected cell culture supernatant for 15?
Positive_regulation (activation) of GTPase
8) Confidence 0.45 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.33 Pain Relevance 0
Induction of Rac1-GTPase was 4.8- fold when compared to Rac1-GTPase activity in the presence of uninfected cell culture supernatant suggesting that PGE2 is enough to induce Rac1-GTPase in the adhering endothelial cells.
Positive_regulation (Induction) of GTPase in endothelial cells
9) Confidence 0.45 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.24 Pain Relevance 0
About 1.8, 2, 3 and 2.5- fold activation of Rac1-GTPase was observed at 15?
Positive_regulation (activation) of GTPase
10) Confidence 0.45 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.11 Pain Relevance 0
We observed 3.4, 3.9, 3.8 and 4.5-fold RhoA-GTPase activation upon plating cells in the presence of infected cell culture supernatant for 15?
Positive_regulation (activation) of GTPase
11) Confidence 0.45 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.80 Pain Relevance 0
Gx/z is regulated by mu but not delta opioid receptors in the stimulation of the low Km GTPase activity in mouse periaqueductal grey matter.
Positive_regulation (stimulation) of GTPase in grey matter associated with periaqueductal grey, enkephalin and delta opioid receptors
12) Confidence 0.34 Published 1997 Journal Eur. J. Neurosci. Section Title Doc Link 9215703 Disease Relevance 0.34 Pain Relevance 1.15
Opiate stimulation of GTPase and inhibition of adenylyl cyclase were fully expressed prenatally.
Positive_regulation (stimulation) of GTPase associated with opiate
13) Confidence 0.31 Published 1991 Journal FEBS Lett. Section Abstract Doc Link 1652479 Disease Relevance 0 Pain Relevance 0.10
HT-29 cells, which express dominant negative p53 and show no increase of GTPase activity when treated with morphine, were less sensitive in vitro and were not affected in vivo.
Neg (no) Positive_regulation (increase) of GTPase in HT-29 associated with morphine
14) Confidence 0.25 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 0.69 Pain Relevance 1.04
In MCF-7 and MDA-MB231 cells, morphine caused a naloxone (Nx)- and pertussis toxin-sensitive, concentration-dependent increase of GTPase activity, indicating that morphine signals could be transduced by opioid receptors via a G protein.
Positive_regulation (increase) of GTPase in MCF-7 associated with bordatella infection, narcan, opioid receptor and morphine
15) Confidence 0.25 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 0.92 Pain Relevance 1.27
When co-expressed with either the opioid-receptor-like (ORL1) receptor or one of the mu, delta, and kappa opioid receptors, by transfecting dual-expression plasmids into COS-7 cells, the full-length GAIP/RGS19 was more effective than the N-terminally truncated variant and was more selective in regulating the ORL1 receptor signaling than in regulating the mu, delta, and kappa opioid receptors, as measured by the effectiveness to increase the agonist-stimulated GTPase activity and to reverse the agonist-induced inhibition of cyclic AMP accumulation.
Positive_regulation (increase) of GTPase associated with agonist, kappa opioid receptor and opioid
16) Confidence 0.21 Published 2005 Journal J. Mol. Biol. Section Abstract Doc Link 16219326 Disease Relevance 0 Pain Relevance 0.47
The analgesic response due to CNF1 requires both the sustained activation of the Rac GTPase, with consequent cerebral actin cytoskeleton remodeling, and the up-regulation of the mu-opioid receptors (MORs), the most important receptors controlling pain perception.
Positive_regulation (activation) of Rac GTPase associated with pain, analgesic and mu opioid receptor
17) Confidence 0.17 Published 2009 Journal Pain Section Abstract Doc Link 19608345 Disease Relevance 0.25 Pain Relevance 0.85
The Rac GTPase-activating bacterial protein toxin CNF1 induces analgesia up-regulating mu-opioid receptors.
Positive_regulation (activating) of Rac GTPase associated with analgesic, mu opioid receptor and analgesia
18) Confidence 0.17 Published 2009 Journal Pain Section Title Doc Link 19608345 Disease Relevance 0.20 Pain Relevance 1.10
Recently, we have demonstrated that the Rac GTPase is also activated and subsequently translocated from the cytosol to the membrane of THP-1 monocytes in a fA?
Positive_regulation (activated) of GTPase in monocytes
19) Confidence 0.12 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.08 Pain Relevance 0.03
It will be important to determine whether an interaction of Hsp70 with Drp1 may aid its refolding or prevent aggregation to minimize increased GTPase activity and organelle fission.
Positive_regulation (increased) of GTPase
20) Confidence 0.11 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.47 Pain Relevance 0.16

General Comments

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