INT127253

Context Info Confidence 0.29 First Reported 2005 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.61 Pain Relevance 1.55

extracellular region (Npb) plasma membrane (Npbwr1) signal transducer activity (Npbwr1)

Npb (Rattus norvegicus) Npbwr1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuropeptide 24 100.00 Hippocampus 2 95.20 Spinal cord 3 92.16 Opioid 2 85.60 Somatostatin 2 84.72 intrathecal 5 79.84 allodynia 7 75.00 Sciatic nerve 4 75.00 IPN 2 75.00 Thermal hyperalgesia 1 41.04

Disease Link Frequency Relevance Heat Neuropathic Pain 7 75.00 Hyperalgesia 2 75.00 Inflammatory Pain 2 75.00 Nociception 5 65.04 Nervous System Injury 1 25.00 Ganglion Cysts 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Neuropeptide W-23 (NPW23) is an endogenous ligand of both GPR7 and GPR8, and neuropeptide B (NPB) is an endogenous ligand of GPR7.

NPB Binding (ligand) of GPR7 associated with neuropeptide

1) Confidence 0.29 Published 2005 Journal Brain Res. Section Abstract Doc Link 15910767 Disease Relevance 0.35 Pain Relevance 0.58

Neuropeptide W-23 and neuropeptide B are each an endogenous ligand of GPR7.

neuropeptide B Binding (ligand) of GPR7 associated with neuropeptide

2) Confidence 0.21 Published 2006 Journal Neuroscience Section Abstract Doc Link 16289588 Disease Relevance 0.26 Pain Relevance 0.97

General Comments

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