INT127263

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) signal transduction (Adra2a) aging (Jun)
nucleus (Jun) plasma membrane (Adra2a) DNA binding (Jun)
Anatomy Link Frequency
medulla 4
Adra2a (Rattus norvegicus)
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 14 100.00 Very High Very High Very High
medulla 6 97.64 Very High Very High Very High
agonist 6 74.68 Quite High
Clonidine 4 61.92 Quite High
Disease Link Frequency Relevance Heat
Hypotension 16 100.00 Very High Very High Very High
Hypertension 2 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest: (1) the c-jun containing neurons in the brainstem are involved in the centrally mediated hypotension elicited by centrally acting antihypertensive agents, and (2) the alpha2-adrenoceptor modulates c-jun gene expression in the NTS and rostral ventrolateral medulla implicated in centrally mediated hypotension, and (3) the imidazoline I1 receptor mediated inhibition of c-jun gene expression in the rostral ventrolateral medulla, but not in the NTS, contributes to the centrally mediated hypotension by the second generation drugs.
alpha2-adrenoceptor Regulation (modulates) of Gene_expression (expression) of c-jun in medulla associated with medulla, rostral ventrolateral medulla and hypotension
1) Confidence 0.07 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.54 Pain Relevance 0.47
These results suggest: (1) the c-jun containing neurons in the brainstem are involved in the centrally mediated hypotension elicited by centrally acting antihypertensive agents, and (2) the alpha2-adrenoceptor modulates c-jun gene expression in the NTS and rostral ventrolateral medulla implicated in centrally mediated hypotension, and (3) the imidazoline I1 receptor mediated inhibition of c-jun gene expression in the rostral ventrolateral medulla, but not in the NTS, contributes to the centrally mediated hypotension by the second generation drugs.
alpha2-adrenoceptor Regulation (contributes) of Gene_expression (expression) of c-jun in medulla associated with medulla, rostral ventrolateral medulla and hypotension
2) Confidence 0.05 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15910806 Disease Relevance 0.56 Pain Relevance 0.48

General Comments

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