INT127283

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 11.80
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
monocytes 4
intestinal epithelium 4
brain 2
lung 2
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 16 99.30 Very High Very High Very High
Inflammatory response 60 99.16 Very High Very High Very High
cva 16 98.88 Very High Very High Very High
cINOD 11 98.84 Very High Very High Very High
Inflammation 364 98.00 Very High Very High Very High
ischemia 16 79.68 Quite High
rheumatoid arthritis 80 79.20 Quite High
hyperexcitability 12 17.84 Low Low
cytokine 27 14.72 Low Low
Crohn's disease 50 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cerebrovascular Disease 2 99.98 Very High Very High Very High
Disease 718 99.92 Very High Very High Very High
Brain Injury 4 99.84 Very High Very High Very High
Atherosclerosis 16 99.60 Very High Very High Very High
Inflammatory Bowel Disease 192 99.54 Very High Very High Very High
Rheumatic Diseases 32 99.00 Very High Very High Very High
INFLAMMATION 423 98.96 Very High Very High Very High
Cv General 3 Under Development 14 98.88 Very High Very High Very High
Adult Respiratory Distress Syndrome 61 98.62 Very High Very High Very High
Aneurism 4 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The modulation of HO-1 gene expression in LDL-C receptor-deficient mice influence the progression of atherosclerosis [17], and mice treated with the HO-1 inducer exhibited reduced atherosclerotic lesion formation.
Regulation (modulation) of Gene_expression (expression) of HO-1 gene associated with atherosclerosis
1) Confidence 0.61 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.22 Pain Relevance 0.04
Levels of HO-1 mRNA expression were not altered by treatment with colchicine or prednisolone in the patients (data not shown).


Neg (not) Regulation (altered) of Gene_expression (expression) of HO-1 mRNA
2) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.62 Pain Relevance 0
The suppressive effect on HO-1 expression was completely abrogated by a LPS neutrizer, namely polymyxin B (Figure 3a).
Regulation (effect) of Gene_expression (expression) of HO-1
3) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.47 Pain Relevance 0.04
In contrast, naproxen (a non-selective NSAID) and rofecoxib (a selective inhibitor of COX-2), did not affect HO-1 expression.
Neg (not) Regulation (affect) of Gene_expression (expression) of HO-1 associated with cinod
4) Confidence 0.45 Published 2005 Journal Eur J Pharm Sci Section Abstract Doc Link 15911218 Disease Relevance 0.07 Pain Relevance 0.18
Two studies focused HO-1 mocroglia/macrophage and cerebrovascular disease speculated the prolong expression of HO-1 in traumatic brain injury, cerebral infarction and aneurysms [7,10].
Regulation (speculated) of Gene_expression (expression) of HO-1 in brain associated with cerebrovascular disease, aneurism, cva and brain injury
5) Confidence 0.45 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.74 Pain Relevance 0.19
In addition, we have also found that the change in HSP32 RNA expression is positively correlated to the change of bcl-2 transcripts (r = 0.82; P = 0.003; 95% CI: 0.96 to 0.41; ES 0.2) (Figure 5).


Regulation (change) of Gene_expression (expression) of HSP32 RNA
6) Confidence 0.37 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0 Pain Relevance 0
In our previous study [26] we showed that TNF suppresses HO-1 expression levels in human peripheral monocytes, thereby accelerating inflammatory responses; this suggests that excessive TNF levels contribute to defective HO-1 expression.
Regulation (contribute) of Gene_expression (expression) of HO-1 in monocytes associated with inflammatory response
7) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.09 Pain Relevance 0.12
Because LPS (a TLR4 ligand) has been shown to suppress interleukin-10-dependent HO-1 expression in human PBMCs [29], it is plausible that excessively expressed TLR4 contributes to defective HO-1 expression in PBMCs from BD patients.
Regulation (dependent) of Gene_expression (expression) of HO-1 associated with disease
8) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.69 Pain Relevance 0.04
antibody infliximab did not eliminate the suppressive effect of LPS on HO-1 expression in monocytes in vitro (Additional file 3).
Regulation (effect) of Gene_expression (expression) of HO-1 in monocytes associated with infliximab
9) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.23 Pain Relevance 0.05
No effect of forced HO-1 expression on TLR2 and TLR4 mRNA in human PBMCs
Neg (No) Regulation (effect) of Gene_expression (expression) of HO-1
10) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.16 Pain Relevance 0.05
Dysregulation of HO-1 expression is associated with some rheumatic diseases.
Regulation (Dysregulation) of Gene_expression (expression) of HO-1 associated with rheumatic diseases
11) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.84 Pain Relevance 0.13
Taken together, our findings implicate the involvement of excessive TLR4 expression in low levels of HO-1 mRNA expression in PBMCs from patients with BD.


Regulation (involvement) of Gene_expression (expression) of HO-1 mRNA associated with disease
12) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.65 Pain Relevance 0.07
Heme oxygenase-1 (HO-1) acts in cytoprotection against acute lung injury, and the polymorphic (GT)n repeat in the HO-1 gene (HMOX1) promoter regulates HMOX1 expression.
Regulation (regulates) of Gene_expression (expression) of HMOX1 in lung associated with adult respiratory distress syndrome
13) Confidence 0.15 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2837179 Disease Relevance 1.25 Pain Relevance 0
For example, patients with IBD demonstrate decreased expression of the anti-oxidant heme-oxygenase-1 (HO-1) in the intestinal epithelium of inflamed colonic mucosa, compared to control specimens, suggesting dysregulated expression in inflammation [80].
Regulation (control) of Gene_expression (expression) of HO-1 in intestinal epithelium associated with inflammatory bowel disease and inflammation
14) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.39 Pain Relevance 0.19
For example, patients with IBD demonstrate decreased expression of the anti-oxidant heme-oxygenase-1 (HO-1) in the intestinal epithelium of inflamed colonic mucosa, compared to control specimens, suggesting dysregulated expression in inflammation [80].
Regulation (control) of Gene_expression (expression) of heme-oxygenase-1 in intestinal epithelium associated with inflammatory bowel disease and inflammation
15) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.39 Pain Relevance 0.19

General Comments

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