INT127291

Context Info Confidence 0.67 First Reported 2005 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 7 Total Number 8 Disease Relevance 4.26 Pain Relevance 0.55

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB) DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)

Anatomy Link Frequency liver 4 red blood cell 1 kidney 1 ALB (Homo sapiens)

Pain Link Frequency Relevance Heat intrathecal 1 95.84 Spinal cord 1 90.52 Neuropathic pain 1 86.60 diabetic neuropathy 13 84.88 Migraine 1 78.32 cva 2 77.92 Inflammation 6 62.92 lidocaine 1 54.32 imagery 1 54.08 fibrosis 6 53.12

Disease Link Frequency Relevance Heat Injury 40 97.92 Nephritis 46 95.00 Hepatotoxicity 24 93.36 Edema 43 91.76 Syndrome 6 90.88 Diabetes Mellitus 37 90.36 Focal Dystonia 1 89.04 Brain Tumor 1 88.40 Infarction 1 87.88 Proteinuria 3 86.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In part two, where patients with albuminous urine and abnormal kidneys are discussed, Cotugno is accredited with the first description of albumin in the urine in 1770, but Rayer surprisingly disagrees with his theory that albumin could leak through the kidney into the urine, in other words protein-losing nephritis.

Transcription (description) of albumin in kidney associated with nephritis

1) Confidence 0.67 Published 2005 Journal Medical History. Supplement Section Body Doc Link PMC2632782 Disease Relevance 0.77 Pain Relevance 0

Patients who had microalbuminuria were included in the study (albumin excretion rate of 20–200 ?

Transcription (rate) of albumin

2) Confidence 0.67 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2658015 Disease Relevance 0.74 Pain Relevance 0.12

Furthermore, human-specific ALB mRNA was expressed in the liver, and human ALB was detected in the serum only in the mobilized CD34+ HSCs-treated mice.

Transcription (expressed) of ALB in liver

3) Confidence 0.56 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.15 Pain Relevance 0

The mRNA expression levels of albumin and cytochrome P450 (CYP3A29) were determined by RT-PCR method.

Spec (determined) Transcription (expression) of albumin

4) Confidence 0.47 Published 2005 Journal Biomed Mater Eng Section Abstract Doc Link 15912001 Disease Relevance 0 Pain Relevance 0.05

Furthermore, human-specific ALB mRNA was expressed in the liver, and human ALB was detected in the serum only in the mobilized CD34+ HSCs-treated mice.

Transcription (detected) of ALB in liver

5) Confidence 0.47 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.15 Pain Relevance 0

However, in the mice (G1) with radiation-mediated liver injury that received CD34+ HSCs transplantation 21 days later, RT-PCR analysis showed that human GS, CK19 and ALB mRNA were expressed (Figure 3), which meant a portion of the transplanted human stem cells had localized to the liver and had begun to express human ALB when analyzed 21 days after the liver damage.

Transcription (expressed) of ALB in liver associated with injury and hepatotoxicity

6) Confidence 0.42 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.19 Pain Relevance 0

We did not detect human albumin within the liver at any stage after transplantation (Fig. 6A).

Neg (not) Transcription (detect) of albumin in liver

7) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.23 Pain Relevance 0.03

CSF cytology, CSF white and red blood cell count, total protein, CSF to serum albumin quotient (Qalb i.e.

Transcription (serum) of albumin in red blood cell

8) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2998475 Disease Relevance 2.03 Pain Relevance 0.36

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