INT1273

Context Info Confidence 0.78 First Reported 1976 Last Reported 2010 Negated 19 Speculated 10 Reported most in Abstract Documents 356 Total Number 366 Disease Relevance 90.56 Pain Relevance 138.70

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp) response to stress (Avp) signal transducer activity (Avp)

Anatomy Link Frequency PVN 41 neurons 29 plasma 28 hypothalamus 18 brain 11 Avp (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 701 100.00 Pain 550 100.00 agonist 374 100.00 Enkephalin 359 100.00 Neuropeptide 289 100.00 Somatostatin 277 100.00 substance P 232 100.00 headache 229 100.00 narcan 168 100.00 Serotonin 165 100.00

Disease Link Frequency Relevance Heat Pain 602 100.00 Stress 528 100.00 Headache 240 100.00 Heart Rate Under Development 99 99.98 Urological Neuroanatomy 125 99.84 Diabetes Mellitus 87 99.84 Chronic Renal Failure 561 99.82 Apoptosis 424 99.80 Aggression 372 99.80 Nociception 74 99.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Intracerebroventricular (ICV) injections of arginine vasopressin (AVP) in doses of 0.015 nmoles and 0.15 nmoles produced a fall in mean actual pressure heart rate and respiration in pentobarbital anesthetized rats.

Gene_expression (produced) of AVP in heart associated with intracerebroventricular

1) Confidence 0.78 Published 1985 Journal Neuropeptides Section Abstract Doc Link 4058686 Disease Relevance 0.06 Pain Relevance 0.10

Dual staining in situ hybridization of forskolin-stimulated hypothalamic sections using both radio labeled AVP hnRNA and digoxigenin-labeled CRH mRNA probes revealed colocalization of both transcripts, indicating AVP hnRNA is expressed in the parvocellular neurons.

Gene_expression (expressed) of AVP hnRNA in neurons

2) Confidence 0.78 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.13

Forskolin-induced AVP hnRNA expression was unaffected by blockage of neurotransmission by the sodium channel inhibitor, tetrodotoxin, indicating that forskolin acts directly on AVP cells in the PVN.

Gene_expression (expression) of AVP hnRNA in PVN associated with tetrodotoxin and sodium channel

3) Confidence 0.78 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.15

Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures.

Gene_expression (expression) of vasopressin gene in neurons

4) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Title Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.25

Dexamethasone treatment, in contrast, significantly decreased AVP mRNA expression levels in the PVN, but this inhibitory action was abolished in the presence of DRB or the sodium channel blocker tetrodotoxin (TTX).

Gene_expression (expression) of AVP mRNA in PVN associated with tetrodotoxin, sodium channel and dexamethasone

5) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.57

In the present study, we examined how cAMP and glucocorticoids regulate AVP gene expression in the parvocellular neurons of the PVN in rat hypothalamic organotypic cultures with in situ hybridization.

Gene_expression (expression) of AVP gene in PVN

6) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.03

However, when the hypothalamic slices were treated with forskolin, dexamethasone decreased AVP mRNA expression even in the presence of DRB and/or TTX.

Gene_expression (expression) of AVP mRNA associated with tetrodotoxin and dexamethasone

7) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.65

Furthermore, AVP hnRNA expression induced by forskolin was attenuated by dexamethasone treatment in the presence of TTX.

Gene_expression (expression) of AVP hnRNA associated with tetrodotoxin and dexamethasone

8) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.66

A series of 2-O-alkylated tyrosine analogues of lysine-vasopressin and desamino-lysine and arginine-vasopressin were synthesized and tested for antidiuretic activity in the water-loaded anaesthetized rat.

Gene_expression (synthesized) of arginine-vasopressin

9) Confidence 0.78 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7461030 Disease Relevance 0 Pain Relevance 0.06

Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion.

Gene_expression (synthesis) of AVP in PVN

10) Confidence 0.78 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.53 Pain Relevance 0.75

The data suggested that AVP in the PVN might be transferred to the NRM to participate in pain modulation.

Gene_expression (transferred) of AVP in PVN associated with pain and raphe magnus

11) Confidence 0.78 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.65 Pain Relevance 1.04

Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion.

Gene_expression (sources) of AVP in PVN

12) Confidence 0.78 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.53 Pain Relevance 0.72

Expression of arginine-vasopressin (AVP), oxytocin (OT), dynorphin and enkephalin genes was studied with the in situ hybridization technique in embryonic rat brain serum-free cultures.

Gene_expression (Expression) of arginine-vasopressin in brain associated with dynorphin and enkephalin

13) Confidence 0.78 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1980642 Disease Relevance 0 Pain Relevance 0.30

After 7 days in culture, AVP gene expression occurred in hypothalamic cultures only, whereas ProOT mRNAs were undetectable.

Gene_expression (expression) of AVP gene

14) Confidence 0.78 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1980642 Disease Relevance 0 Pain Relevance 0.47

These observations demonstrated that AVP, dynorphin and enkephalin, but not OT genes, can be expressed in cultures prepared from embryonic rat brain as young as 16 days old.

Gene_expression (expressed) of AVP in brain associated with dynorphin and enkephalin

15) Confidence 0.78 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1980642 Disease Relevance 0 Pain Relevance 0.56

Expression of arginine-vasopressin (AVP), oxytocin (OT), dynorphin and enkephalin genes was studied with the in situ hybridization technique in embryonic rat brain serum-free cultures.

Gene_expression (Expression) of AVP in brain associated with dynorphin and enkephalin

16) Confidence 0.78 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1980642 Disease Relevance 0 Pain Relevance 0.30

Expression of vasopressin and opiates but not of oxytocin genes studied by in situ hybridization in embryonic rat brain primary cultures.

Gene_expression (Expression) of vasopressin in brain associated with enkephalin and opiate

17) Confidence 0.78 Published 1990 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 1980642 Disease Relevance 0 Pain Relevance 0.60

Prominent arginine-vasopressin (AVP) binding and AVP V(1) type receptors are expressed early in the developing rat spinal cord.

Gene_expression (expressed) of AVP in spinal cord associated with spinal cord

18) Confidence 0.78 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11535670 Disease Relevance 0 Pain Relevance 0.15

The objective of this clinical study is to investigate the circadian rhythm of both urine production and plasma arginine-vasopressin (AVP) level, and the efficacy of intranasal instillation of 1-deamino-8-D-arginine-vasopressin (DDAVP) in adult patients complaining of nocturia.

Spec (investigate) Gene_expression (production) of AVP in plasma associated with overactive bladder

19) Confidence 0.78 Published 1993 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8309120 Disease Relevance 0.34 Pain Relevance 0.03

Hence, a functional MAPK signaling pathway appears to be critical for AVP gene expression in the SCN.

Gene_expression (expression) of AVP gene in SCN

20) Confidence 0.78 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.47

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