INT127320

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.11
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
hippocampus 1
Gpx3 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 2 95.36 Very High Very High Very High
Inflammation 36 93.76 High High
Glutamate receptor 1 65.12 Quite High
antagonist 1 63.60 Quite High
Mechanotransduction 4 53.12 Quite High
tetrodotoxin 1 52.96 Quite High
Glutamate 1 25.00 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 32 94.64 High High
INFLAMMATION 36 93.76 High High
Lung Injury 116 92.72 High High
Hyperhomocysteinemia 2 92.28 High High
Neurological Disease 1 90.08 High High
Injury 16 72.44 Quite High
Pneumonia 2 71.20 Quite High
Death 14 64.52 Quite High
Multiple Organ Failure 2 63.56 Quite High
Adult Respiratory Distress Syndrome 12 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show an activation of the extracellular signal-regulated kinases (ERK1 and ERK2) and the downstream nuclear targets Elk-1 and calcium/cAMP response element binding protein, in the hippocampus of cystathionine beta synthase deficient mice, a murine model of hyperhomocysteinemia.
extracellular Regulation (regulated) of kinases in hippocampus associated with hippocampus and hyperhomocysteinemia
1) Confidence 0.00 Published 2005 Journal Neuroscience Section Abstract Doc Link 15916860 Disease Relevance 0.27 Pain Relevance 0.20
The MAPK superfamily includes three primary signaling cascades: the extracellular signal regulated kinases (ERK1/2), the c-Jun NH2-terminal kinases (JNK) and the p38 MAPKs.
extracellular Regulation (regulated) of kinases
2) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 1.41 Pain Relevance 0.15
The MAPK superfamily includes three primary signaling cascades: the extracellular signal regulated kinases (ERK1/2), the c-Jun NH2-terminal kinases (JNK) and the p38 MAPKs.
extracellular Regulation (regulated) of kinases
3) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 1.43 Pain Relevance 0.18

General Comments

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