INT127323

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 0.96
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 18 99.98 Very High Very High Very High
Pain 13 95.32 Very High Very High Very High
TRP channel 30 93.24 High High
addiction 2 78.96 Quite High
Inflammation 2 75.56 Quite High
Hyperalgesia 6 74.16 Quite High
Potency 5 65.92 Quite High
Root ganglion neuron 23 30.56 Quite Low
alcohol 6 22.52 Low Low
qutenza 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 6 94.88 High High
Neurogenic Inflammation 1 75.56 Quite High
Stress 6 75.00 Quite High
Hyperalgesia 6 74.16 Quite High
Ganglion Cysts 28 50.00 Quite Low
Loss Of Sense Of Smell 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Pruritus 2 5.00 Very Low Very Low Very Low
Bites And Stings 1 5.00 Very Low Very Low Very Low
Tick Infestations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that, via generation of reactive oxygen species, light-induced TRPA1 activation provides an additional mode of activation, which renders TRPA1 a likely molecular candidate in processes leading to painful or burning sensations during photodynamic therapy or upon local application of hydrogen peroxide.
Positive_regulation (induced) of Positive_regulation (activation) of TRPA1 associated with pain
1) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.07 Pain Relevance 0.10
In the presence of the photosensitising agents acridine orange (100 nM) or hypericin (10 nM), the sensitivity of light-induced TRPA1 activation was increased and extended towards the visible spectrum.
Positive_regulation (induced) of Positive_regulation (activation) of TRPA1
2) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.15 Pain Relevance 0.07
Since extracellular application of hydrogen peroxide mimicked the effect of UVA irradiation and since dithiothreitol partly reversed the activation by UVA exposure, we conclude that reactive oxygen species may mediate the light-induced activation of TRPA1.
Spec (may) Positive_regulation (mediate) of Positive_regulation (activation) of TRPA1
3) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.14 Pain Relevance 0.12
Intracellular but not extracellular application of FeSO(4), which catalyses the formation of highly reactive hydroxyl radicals potentiated the hydrogen peroxide-stimulated TRPA1 activation.
Positive_regulation (stimulated) of Positive_regulation (activation) of TRPA1
4) Confidence 0.50 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.07 Pain Relevance 0.08
Accordingly, hydrogen peroxide induced a TRPA1 activation with a membrane-delimited mode of action that was attenuated by dithiothreitol.
Positive_regulation (induced) of Positive_regulation (activation) of TRPA1
5) Confidence 0.47 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.13 Pain Relevance 0.12
In the presence of the photosensitising agents acridine orange (100 nM) or hypericin (10 nM), the sensitivity of light-induced TRPA1 activation was increased and extended towards the visible spectrum.
Positive_regulation (increased) of Positive_regulation (activation) of TRPA1
6) Confidence 0.47 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.15 Pain Relevance 0.07
Here, we report that electrophilic, thioaminal-containing compounds [e.g., CMP1 (4-methyl-N-[2,2,2-trichloro-1-(4-nitro-phenylsulfanyl)-ethyl]-benzamide)] covalently modify cysteine residues but produce striking species-specific effects [i.e., activation of rat TRPA1 (rTRPA1) and blockade of human TRPA1 (hTRPA1) activation by reactive and nonreactive agonists].
Positive_regulation (activation) of Positive_regulation (activation) of TRPA1 associated with agonist
7) Confidence 0.46 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463259 Disease Relevance 0.15 Pain Relevance 0.16
In contrast, agonist activation of TRPM8, TRPV4, and TRPA1 was not increased or potentiated by citral (Fig. 2D, E).
Neg (not) Positive_regulation (increased) of Positive_regulation (activation) of TRPA1 associated with agonist
8) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.51
We further show that allicin, an unstable component of fresh garlic, is the chemical responsible for TRPA1 and TRPV1 activation and is therefore likely to cause garlic's pungency.
Positive_regulation (responsible) of Positive_regulation (activation) of TRPA1
9) Confidence 0.30 Published 2005 Journal Curr. Biol. Section Abstract Doc Link 15916949 Disease Relevance 0.09 Pain Relevance 0.18

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