INT127329

Context Info Confidence 0.41 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 0.51 Pain Relevance 0.60

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)

Anatomy Link Frequency plasma 4 Tbpl1 (Mus musculus)

Pain Link Frequency Relevance Heat Acute pain 1 98.90 antagonist 9 96.32 qutenza 4 79.04 Pain 4 75.00 Dopamine 116 72.72 Substantia nigra 12 66.60 Serotonin 12 50.00 monoamine 4 41.52 bradykinin 1 30.96 IPN 1 25.00

Disease Link Frequency Relevance Heat Pain 2 98.90 Fatigue 96 85.04 Stress 36 63.56 Heat Stress Disorders 4 30.36 Fever 20 5.00 Pressure And Volume Under Development 4 5.00 Depression 4 5.00 Hypothermia 4 5.00 Respiratory Disease 4 5.00 Injury 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We show here that acute pain-related behavior evoked by elevated ionic strength is abolished in TRP vanilloid subtype 1 (TRPV1)-null mice and inhibited by iodoresiniferatoxin, a potent TRPV1 antagonist.

Negative_regulation (abolished) of TRP associated with antagonist and acute pain

1) Confidence 0.41 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15917451 Disease Relevance 0.17 Pain Relevance 0.44

Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.

Negative_regulation (reduction) of Trp in plasma

2) Confidence 0.23 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0

Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.

Negative_regulation (reduction) of Trp in plasma

3) Confidence 0.23 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0

Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.

Negative_regulation (reduction) of Trp in plasma

4) Confidence 0.23 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0

According to Wurtman [40] for example in order to elicit a reduction in brain Trp uptake and, therefore, attenuation in brain 5-HT turnover, a 5- to 6-fold elevation in plasma [LNAA] is required.

Negative_regulation (reduction) of Trp in plasma

5) Confidence 0.23 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.16 Pain Relevance 0.17

General Comments

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