INT127329

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.51
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)
Anatomy Link Frequency
plasma 4
Tbpl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Acute pain 1 98.90 Very High Very High Very High
antagonist 9 96.32 Very High Very High Very High
qutenza 4 79.04 Quite High
Pain 4 75.00 Quite High
Dopamine 116 72.72 Quite High
Substantia nigra 12 66.60 Quite High
Serotonin 12 50.00 Quite Low
monoamine 4 41.52 Quite Low
bradykinin 1 30.96 Quite Low
IPN 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 2 98.90 Very High Very High Very High
Fatigue 96 85.04 High High
Stress 36 63.56 Quite High
Heat Stress Disorders 4 30.36 Quite Low
Fever 20 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Hypothermia 4 5.00 Very Low Very Low Very Low
Respiratory Disease 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that acute pain-related behavior evoked by elevated ionic strength is abolished in TRP vanilloid subtype 1 (TRPV1)-null mice and inhibited by iodoresiniferatoxin, a potent TRPV1 antagonist.
Negative_regulation (abolished) of TRP associated with antagonist and acute pain
1) Confidence 0.41 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15917451 Disease Relevance 0.17 Pain Relevance 0.44
Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.
Negative_regulation (reduction) of Trp in plasma
2) Confidence 0.23 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0
Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.
Negative_regulation (reduction) of Trp in plasma
3) Confidence 0.23 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0
Since differences in plasma volume, which could partially explain the reduction in plasma free-[Trp] and free-Trp:Tyr ratio were not observed in the present experiment, the exact mechanism(s) responsible for the observed reduction in plasma free-[Trp] and free-Trp:Tyr ratio after Cr loading (despite no difference in plasma [FFA]) and the significance of these observations remain to be determined.
Negative_regulation (reduction) of Trp in plasma
4) Confidence 0.23 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.06 Pain Relevance 0
According to Wurtman [40] for example in order to elicit a reduction in brain Trp uptake and, therefore, attenuation in brain 5-HT turnover, a 5- to 6-fold elevation in plasma [LNAA] is required.
Negative_regulation (reduction) of Trp in plasma
5) Confidence 0.23 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2570654 Disease Relevance 0.16 Pain Relevance 0.17

General Comments

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