INT127336

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.37
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
amygdala 4
anterior pituitary 2
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 7 99.98 Very High Very High Very High
amygdala 53 99.16 Very High Very High Very High
Pain 33 98.88 Very High Very High Very High
Visceral pain 2 97.76 Very High Very High Very High
Neuropathic pain 6 93.60 High High
Limbic system 4 88.92 High High
Lasting pain 7 87.56 High High
Sciatic nerve 1 85.64 High High
Endogenous opioid 2 83.84 Quite High
Intracerebroventricular 1 83.04 Quite High
Disease Link Frequency Relevance Heat
Injury 7 99.98 Very High Very High Very High
Pain 40 98.88 Very High Very High Very High
Stress 3 98.72 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 97.76 Very High Very High Very High
Neuropathic Pain 6 93.60 High High
Anxiety Disorder 31 93.28 High High
Nociception 4 91.28 High High
Colitis 1 87.28 High High
Traumatic Stress Disorders 1 75.76 Quite High
Arthritis 23 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCI increased the expression of corticotrophin releasing hormone mRNA in the central amygdala, and not the paraventricular nucleus of the hypothalamus or the bed nucleus of the stria terminalis.
Neg (not) Positive_regulation (increased) of Transcription (expression) of corticotrophin releasing hormone in amygdala associated with eae and amygdala
1) Confidence 0.48 Published 2006 Journal Physiol. Behav. Section Abstract Doc Link 16647726 Disease Relevance 1.96 Pain Relevance 1.48
Increased expression of CRF1 receptor mRNA was detected in the amygdala in a model of somato-visceral pain induced by intra-peritoneal acetic acid [46].
Positive_regulation (Increased) of Transcription (expression) of CRF1 receptor in amygdala associated with visceral pain and amygdala
2) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC1891279 Disease Relevance 1.30 Pain Relevance 1.49
In situ hybridization revealed increased corticotrophin releasing hormone (CRH) mRNA expression in the dorsomedial parvocellular paraventricular nucleus (pPVN) and increased anterior pituitary pro-opiomelanocortin mRNA expression 4 h after IL-1beta in virgins; these responses were absent in pregnant rats.
Positive_regulation (increased) of Transcription (expression) of corticotrophin releasing hormone in anterior pituitary
3) Confidence 0.33 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15917452 Disease Relevance 0 Pain Relevance 0.22

General Comments

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