INT12734

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 1997
Negated 2
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 2.23
Pain Relevance 7.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
thyroid 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 41 100.00 Very High Very High Very High
narcan 19 100.00 Very High Very High Very High
analgesia 8 100.00 Very High Very High Very High
antagonist 4 99.96 Very High Very High Very High
Pain 11 99.92 Very High Very High Very High
Immobilon 2 99.92 Very High Very High Very High
Enkephalin 7 98.12 Very High Very High Very High
Morphine 11 95.32 Very High Very High Very High
Analgesic 2 91.84 High High
tail-flick 1 90.04 High High
Disease Link Frequency Relevance Heat
Thyroid Disease 2 100.00 Very High Very High Very High
Parkinson's Disease 4 99.84 Very High Very High Very High
Pain 8 99.80 Very High Very High Very High
Obesity 11 99.36 Very High Very High Very High
Shock 3 91.64 High High
Pressure Volume 2 Under Development 1 86.32 High High
Anxiety Disorder 1 84.04 Quite High
Body Weight 1 73.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxazone, a long-acting opiate antagonist: effects on analgesia in intact animals and on opiate receptor binding in vitro.
Regulation (effects) of opiate receptor Binding (binding) of associated with antagonist, narcan, opiate and analgesia
1) Confidence 0.62 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6105201 Disease Relevance 0 Pain Relevance 1.25
The effect of hyperthyroidism on opiate receptor binding and pain sensitivity.
Regulation (effect) of opiate receptor Binding (binding) of associated with pain, thyroid disease, opiate and immobilon
2) Confidence 0.59 Published 1990 Journal Life Sci. Section Title Doc Link 2176266 Disease Relevance 0.37 Pain Relevance 1.26
Further studies examined the effect of guanine nucleotide on opiate receptor interaction.
Spec (examined) Regulation (effect) of opiate receptor Spec (examined) Binding (interaction) of associated with opiate
3) Confidence 0.48 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6287304 Disease Relevance 0 Pain Relevance 0.76
This study was conducted to determine the effect of thyroid hormone on opiate receptor ligand-binding and pain sensitivity.
Spec (determine) Regulation (effect) of opiate receptor Binding (ligand-binding) of in thyroid associated with pain and opiate
4) Confidence 0.44 Published 1990 Journal Life Sci. Section Abstract Doc Link 2176266 Disease Relevance 0.30 Pain Relevance 0.62
[The effect of opiate receptor ligands on emotional cardiovascular reactions in lower primates].
Regulation (effect) of opiate receptor Binding (ligands) of associated with narcan and opiate
5) Confidence 0.43 Published 1987 Journal Biull Eksp Biol Med Section Title Doc Link 3032302 Disease Relevance 0.41 Pain Relevance 0.48
Alterations in opiate receptor binding in MPTP-induced hemiparkinsonian monkeys.
Regulation (Alterations) of opiate receptor Binding (binding) of associated with parkinson's disease, narcan and opiate
6) Confidence 0.42 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 1652716 Disease Relevance 0.35 Pain Relevance 0.24
The alterations in chemical structure affected affinity of the analogs to the opiate receptor and their pharmacologic properties differently, suggesting that different opiate subtypes may be involved.
Regulation (affected) of opiate receptor Binding (affinity) of associated with opiate
7) Confidence 0.38 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6152318 Disease Relevance 0 Pain Relevance 0.67
The effects of dietary sucrose on opiate receptor binding in genetically obese (ob/ob) and lean mice.
Regulation (effects) of opiate receptor Binding (binding) of associated with obesity and opiate
8) Confidence 0.27 Published 1989 Journal J Am Coll Nutr Section Title Doc Link 2538498 Disease Relevance 0.81 Pain Relevance 0.34
Since ethanol, in vitro, does decrease striatal opiate receptor binding, the results suggest that the changes in affinity detected by ligand binding studies are not relevant for receptor-coupled adenylate cyclase activity, or that opiate receptor binding and opiate regulation of adenylate cyclase can be modulated independently.
Neg (independently) Regulation (modulated) of opiate receptor Binding (binding) of associated with opiate
9) Confidence 0.13 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3512771 Disease Relevance 0 Pain Relevance 0.75
Effect of beta-FNA on opiate delta receptor binding.
Regulation (Effect) of opiate delta receptor Binding (binding) of associated with narcan and opiate
10) Confidence 0.03 Published 1984 Journal J. Neurochem. Section Title Doc Link 6088697 Disease Relevance 0 Pain Relevance 0.45
Both the degree of substitution and the identity of the alkyl group affected kappa-receptor affinity, selectivity, and efficacy.
Regulation (affected) of kappa-receptor Binding (affinity) of
11) Confidence 0.01 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9276018 Disease Relevance 0 Pain Relevance 0.29
Since N-Val is the homolog of Pro with an opened pyrrolidine ring, these data show that the cyclic structure of Pro participates in the strong in vivo activity of Pro5 analogs without altering the binding to the opiate receptor.
Neg (without) Regulation (altering) of opiate receptor Binding (binding) of associated with opiate
12) Confidence 0.00 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6249616 Disease Relevance 0 Pain Relevance 0.59

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