INT127341

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 44
Total Number 46
Disease Relevance 3.67
Pain Relevance 13.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SH-SY5Y 5
brain 5
retina 4
ganglion cell 2
neurite 2
Gpm6a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 1624 100.00 Very High Very High Very High
mu opioid receptor 13 100.00 Very High Very High Very High
Nerve growth factor 30 99.96 Very High Very High Very High
analgesia 13 99.96 Very High Very High Very High
Pyramidal cell 30 98.28 Very High Very High Very High
Nicotine 130 98.24 Very High Very High Very High
Opioid 2 97.08 Very High Very High Very High
Perioperative pain 2 95.72 Very High Very High Very High
addiction 2 94.36 High High
Central nervous system 130 94.04 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 250 99.16 Very High Very High Very High
Post Operative Pain 2 95.72 Very High Very High Very High
Neuroblastoma 42 90.52 High High
Retroviridae Infections 60 80.68 Quite High
Pheochromocytoma 30 80.32 Quite High
Pain 10 73.20 Quite High
Stress 20 72.44 Quite High
Decapitation 30 38.48 Quite Low
Dislocations 30 36.48 Quite Low
Infection 64 28.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of M6a-EGFP-expressing cells was lower in the ONL and slightly higher in the INL than that of control EGFP-expressing retinal cells, but both differences were not statistically significant (Figure 2A).
Gene_expression (expressing) of M6a
1) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.14 Pain Relevance 0
The percentage of rhodopsin positive M6a-overexpressing cells was not significantly, but few times higher than that of control cells (Figure 2B).
Gene_expression (-) of M6a
2) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.15 Pain Relevance 0
M6a overexpression does not affect cell fate and subretinal localization of retinal precursors
Gene_expression (overexpression) of M6a
3) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.13 Pain Relevance 0.03
Since previous reports have located M6a immunoreactivity in the synapses of the rat cerebellum and in the axon terminals of the rat cerebellar molecular layer [16], we examined the coexpression of M6a and the presynaptic marker, synaptophysin, by immunostaining with both anti-M6a and antisynaptophysin antibodies (Figure 1E).
Spec (examined) Gene_expression (coexpression) of M6a in molecular layer
4) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.12 Pain Relevance 0.04
M6a overexpression promotes neurite outgrowth in retina
Gene_expression (overexpression) of M6a in retina
5) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0 Pain Relevance 0
m for the M6a-overexpressing cells (39.2 ?
Gene_expression (overexpressing) of M6a
6) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0 Pain Relevance 0
To examine the biologic significance of M6a for retinal development, we investigated the effects of ectopically expressed M6a in a mouse retinal explant culture prepared from E17, which provides an excellent model to monitor retinal differentiation in vitro [13].
Gene_expression (expressed) of M6a
7) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.09 Pain Relevance 0.03
We found that cell fate and subretinal localization of retinal progenitor cells were not affected by M6a overexpression.
Gene_expression (overexpression) of M6a
8) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0 Pain Relevance 0.03
The other retinal cell populations were not affected by M6a overexpression, which suggests that M6a does not play a role in retinal differentiation.


Gene_expression (overexpression) of M6a
9) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.09 Pain Relevance 0
We found that M6a expression colocalized with that of synaptophysin from the embryonic to adult stages (Figure 1E).


Gene_expression (expression) of M6a
10) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.12 Pain Relevance 0.04
Although PLP and its splice variant DM20 are glial proteins, M6a is found exclusively in neurons [7].
Gene_expression (found) of M6a in neurons
11) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0 Pain Relevance 0.14
Treatment of PC12 cells with a PKC inhibitor eliminates the ability of M6a to promote nerve growth factor-primed neurite extension [10].
Gene_expression (promote) of M6a in neurite associated with nerve growth factor
12) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.08 Pain Relevance 0.05
The neurite outgrowth of M6a-overexpressing retinal cells was strikingly enhanced, although M6a did not affect differentiation and proliferation.


Gene_expression (overexpressing) of M6a in neurite
13) Confidence 0.58 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2529470 Disease Relevance 0.08 Pain Relevance 0
The percentage of rhodopsin positive M6a-overexpressing cells was not significantly, but few times higher than that of control cells (Figure 2B).
Gene_expression (overexpressing) of M6a
14) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.15 Pain Relevance 0
At P10 (data not shown) and in the adult retina, strong expression of M6a was detected in the IPL, and weak signals were observed in NFL, OPL, and inner nuclear layer (INL; Figure 1D).


Gene_expression (expression) of M6a in inner nuclear layer
15) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.26 Pain Relevance 0
Immunohistochemistry showed that in the immature mouse retina, M6a was strongly expressed in the axons of retinal ganglion cells.
Gene_expression (expressed) of M6a in retinal ganglion cells associated with ganglion cysts
16) Confidence 0.58 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2529470 Disease Relevance 0.10 Pain Relevance 0
In the E14 retina, M6a was mainly and strongly expressed in the NFL, which consists of the axons of ganglion cells, but was not observed in the neuroblastic layer (NBL), which consists of proliferating retinal progenitor cells (Figure 1B).
Gene_expression (expressed) of M6a in ganglion cells associated with ganglion cysts
17) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.17 Pain Relevance 0
After birth, M6a expression was confined to the inner plexiform layer, and finally, to the inner and outer plexiform layers of adult mouse retina.
Gene_expression (expression) of M6a in inner plexiform layer
18) Confidence 0.58 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2529470 Disease Relevance 0.10 Pain Relevance 0
The expression of M6a paralleled that of the presynaptic protein, synaptophysin, in the mouse retina, suggesting that the subcellular distribution of M6a is the same in the brain and retina.
Gene_expression (expression) of M6a in retina
19) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.07 Pain Relevance 0.04
We also show that the expression of M6a parallels that of synaptophysin.
Gene_expression (expression) of M6a
20) Confidence 0.58 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0 Pain Relevance 0.03

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