INT127353

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.60
Pain Relevance 5.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 6
spinal 4
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 83 100.00 Very High Very High Very High
Spinal cord 105 99.84 Very High Very High Very High
Perioperative pain 10 99.60 Very High Very High Very High
electroacupuncture 16 99.20 Very High Very High Very High
Hyperalgesia 100 98.16 Very High Very High Very High
Ultiva 110 97.52 Very High Very High Very High
intrathecal 36 97.52 Very High Very High Very High
ketamine 72 96.88 Very High Very High Very High
qutenza 6 96.40 Very High Very High Very High
Opioid 14 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Post Operative Pain 10 99.60 Very High Very High Very High
Hyperalgesia 142 98.16 Very High Very High Very High
Pain 38 90.24 High High
Inflammatory Pain 14 81.04 Quite High
Neuropathic Pain 54 80.40 Quite High
Nociception 40 60.20 Quite High
INFLAMMATION 22 50.00 Quite Low
Injury 16 5.00 Very Low Very Low Very Low
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the role of the intracellular calcium chelator, bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA), in modulating the phosphorylation of the spinal N-methyl-d-aspartate receptor (NMDAR) NR1 and NR2B subunits after 2Hz electroacupuncture (EA) in rats.
Regulation (modulating) of Phosphorylation (phosphorylation) of NR2B in spinal associated with electroacupuncture
1) Confidence 0.45 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.44
The present study investigates the role of serine/threonine protein phosphatase 2A (PP2A) in the modulation of the phosphorylation of the NR1 and NR2B subunits of NMDA receptors in the spinal cord of rats following intradermal injection of capsaicin.
Spec (investigates) Regulation (modulation) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with qutenza, nmda receptor and spinal cord
2) Confidence 0.38 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15919130 Disease Relevance 0 Pain Relevance 0.55
In the present study we provide more direct evidence supporting the hypothesis of a role of EphB receptors in physiological synaptic plasticity in vivo, via modulation of NMDA receptor activity, and in particular via Src-mediated phosphorylation of the NR2B subunit.
Regulation (role) of Phosphorylation (phosphorylation) of NR2B associated with nmda receptor
3) Confidence 0.38 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.68 Pain Relevance 1.05
The present study investigated the role of inhibitor of protein phosphatases 1 and 2A on the modulation of the phosphorylation of the spinal N-methyl-D-aspartate receptor (NMDAR) NR1 and NR2B subunits following electroacupuncture (EA) stimulation in rats.
Regulation (modulation) of Phosphorylation (phosphorylation) of NR2B in spinal associated with nmda receptor and electroacupuncture
4) Confidence 0.36 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.63
PP2 alone did not alter NR2B basal phosphorylation levels (data not shown).
Neg (not) Regulation (alter) of Phosphorylation (phosphorylation) of NR2B
5) Confidence 0.33 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.11 Pain Relevance 0.17
In summary, the present investigation provides evidence for the significant role of NR2B tyrosine phosphorylation in spinal cord in the maintenance of hyreralgesia induced by remifentanil.
Regulation (role) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with ultiva and spinal cord
6) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.13 Pain Relevance 1.07
In the present study, we used a rat model of postoperative pain to investigate the role of tyrosine phosphorylation of NMDA receptor 2B (NR2B) subunit in spinal cord in the postoperative hyperalgesia induced by remifentanil and the intervention of pretreatment with ketamine.


Spec (investigate) Regulation (role) of Spec (investigate) Phosphorylation (phosphorylation) of NR2B in spinal cord associated with hyperalgesia, ketamine, nmda receptor, ultiva, perioperative pain and spinal cord
7) Confidence 0.24 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2809057 Disease Relevance 0.68 Pain Relevance 1.38

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