INT127371

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 6.24
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ager) plasma membrane (Ager) cytoplasm (Ager)
Anatomy Link Frequency
endothelial cells 2
Ager (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 2 99.62 Very High Very High Very High
antagonist 8 98.64 Very High Very High Very High
Inflammatory response 2 97.98 Very High Very High Very High
withdrawal 5 76.00 Quite High
Inflammation 22 25.00 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 12 99.96 Very High Very High Very High
Cv General 3 Under Development 2 99.62 Very High Very High Very High
Neointima 30 99.56 Very High Very High Very High
Injury 100 98.96 Very High Very High Very High
INFLAMMATION 7 97.78 Very High Very High Very High
Diabetes Mellitus 114 97.48 Very High Very High Very High
Stress 12 95.24 Very High Very High Very High
Metastasis 2 92.60 High High
Hyperplasia 25 92.56 High High
Skin Cancer 4 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently found that nifedipine, one of the most widely used dihydropyridine-based calcium antagonists (DHPs) for treatments of patients with angina pectoris and hypertension, inhibited RAGE overexpression in AGE-exposed endothelial cells by suppressing reactive oxygen species generation.
Negative_regulation (inhibited) of Gene_expression (overexpression) of RAGE in endothelial cells associated with angina, antagonist and hypertension
1) Confidence 0.43 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15922119 Disease Relevance 0.90 Pain Relevance 0.28
The breakdown of AGEs in the vascular wall may reduce the expression of RAGE, which is known to be positively regulated, which may result in reduced activation of ERK and a decrease in oxidative stress.
Spec (may) Negative_regulation (reduce) of Gene_expression (expression) of RAGE associated with stress
2) Confidence 0.38 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.71 Pain Relevance 0
Furthermore, we found that the anti-proliferative effect of alagebrium resulted from inhibition of RAGE expression.
Negative_regulation (inhibition) of Gene_expression (expression) of RAGE
3) Confidence 0.38 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 1.33 Pain Relevance 0.03
Since RAGE is a signal-transducing receptor for AGEs and subsequently evokes inflammatory responses in various types of cells, thus eliciting angiogenesis and thrombogenesis, we hypothesize here that blockade of RAGE expression by nifedipine may have therapeutic potentials in treatment of patients with various AGE-related disorders.
Negative_regulation (blockade) of Gene_expression (expression) of RAGE associated with inflammatory response
4) Confidence 0.38 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15922119 Disease Relevance 0.89 Pain Relevance 0.29
Immunohistochemical staining of newly formed neointima showed a significant reduction in RAGE expression (Fig. 5) with significant suppression of neointima formation in alagebrium-treated balloon injured diabetic rats (Fig. 6).
Negative_regulation (reduction) of Gene_expression (expression) of RAGE associated with diabetes mellitus and neointima
5) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.79 Pain Relevance 0
The carotid balloon injury rat model was associated with a markedly increased expression of RAGE, which was significantly attenuated in alagebrium-treated rats (Fig. 5A).
Negative_regulation (attenuated) of Gene_expression (expression) of RAGE associated with injury
6) Confidence 0.25 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.67 Pain Relevance 0.03
Also, analysis of RAGE expression in neointimal tissue, as determined by RT-PCR, showed that alagebrium (1 and 10 ┬ÁM) dose-dependently inhibited the expression of RAGE (by approximately 17% and 84%, respectively) (Fig. 5B).


Negative_regulation (inhibited) of Gene_expression (expression) of RAGE
7) Confidence 0.25 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.86 Pain Relevance 0.04

General Comments

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