INT127372

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 16
Disease Relevance 14.44
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ager) plasma membrane (Ager) cytoplasm (Ager)
Anatomy Link Frequency
smooth muscle cells 2
cardiac myocytes 1
monocytes 1
endothelial cells 1
Ager (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 6 99.42 Very High Very High Very High
antagonist 11 98.44 Very High Very High Very High
Inflammatory response 6 97.74 Very High Very High Very High
imagery 8 87.04 High High
Inflammation 73 79.92 Quite High
withdrawal 8 76.00 Quite High
Calcium channel 11 69.04 Quite High
cytokine 21 62.96 Quite High
anesthesia 8 34.16 Quite Low
ketamine 8 33.00 Quite Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 288 99.96 Very High Very High Very High
Hypertension 59 99.76 Very High Very High Very High
Adhesions 20 99.64 Very High Very High Very High
Cv General 3 Under Development 6 99.42 Very High Very High Very High
Neointima 48 99.30 Very High Very High Very High
Pre-eclampsia 1 99.18 Very High Very High Very High
Injury 177 98.96 Very High Very High Very High
INFLAMMATION 56 97.54 Very High Very High Very High
Increased Venous Pressure Under Development 20 97.52 Very High Very High Very High
Diabetes Mellitus 846 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently found that nifedipine, one of the most widely used dihydropyridine-based calcium antagonists (DHPs) for treatments of patients with angina pectoris and hypertension, inhibited RAGE overexpression in AGE-exposed endothelial cells by suppressing reactive oxygen species generation.
Gene_expression (overexpression) of RAGE in endothelial cells associated with angina, antagonist and hypertension
1) Confidence 0.57 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15922119 Disease Relevance 0.90 Pain Relevance 0.28
Furthermore, we found that the anti-proliferative effect of alagebrium resulted from inhibition of RAGE expression.
Gene_expression (expression) of RAGE
2) Confidence 0.51 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 1.33 Pain Relevance 0.03
The breakdown of AGEs in the vascular wall may reduce the expression of RAGE, which is known to be positively regulated, which may result in reduced activation of ERK and a decrease in oxidative stress.
Gene_expression (expression) of RAGE associated with stress
3) Confidence 0.51 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.71 Pain Relevance 0
Since RAGE is a signal-transducing receptor for AGEs and subsequently evokes inflammatory responses in various types of cells, thus eliciting angiogenesis and thrombogenesis, we hypothesize here that blockade of RAGE expression by nifedipine may have therapeutic potentials in treatment of patients with various AGE-related disorders.
Gene_expression (expression) of RAGE associated with inflammatory response
4) Confidence 0.50 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15922119 Disease Relevance 0.88 Pain Relevance 0.29
Immunohistochemical staining of newly formed neointima showed a significant reduction in RAGE expression (Fig. 5) with significant suppression of neointima formation in alagebrium-treated balloon injured diabetic rats (Fig. 6).
Gene_expression (expression) of RAGE associated with diabetes mellitus and neointima
5) Confidence 0.44 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.79 Pain Relevance 0
Effect of alagebrium on the expression of advanced glycation end-product receptor in rat aortic vascular smooth muscle cells
Gene_expression (expression) of glycation end-product receptor in smooth muscle cells
6) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.32 Pain Relevance 0
Expression of RAGE was visualized by adding 3,3-diaminobenzidine (Vector Laboratories, Burlingame, CA, USA) for 5 minutes.
Gene_expression (Expression) of RAGE
7) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.16 Pain Relevance 0.04
Also, analysis of RAGE expression in neointimal tissue, as determined by RT-PCR, showed that alagebrium (1 and 10 µM) dose-dependently inhibited the expression of RAGE (by approximately 17% and 84%, respectively) (Fig. 5B).


Gene_expression (expression) of RAGE
8) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.71 Pain Relevance 0.03
Also, analysis of RAGE expression in neointimal tissue, as determined by RT-PCR, showed that alagebrium (1 and 10 µM) dose-dependently inhibited the expression of RAGE (by approximately 17% and 84%, respectively) (Fig. 5B).


Gene_expression (expression) of RAGE
9) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.86 Pain Relevance 0.04
The carotid balloon injury rat model was associated with a markedly increased expression of RAGE, which was significantly attenuated in alagebrium-treated rats (Fig. 5A).
Gene_expression (expression) of RAGE associated with injury
10) Confidence 0.34 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.59 Pain Relevance 0.03
OTHER FACTORS STUDIED AS MARKERS FOR ERECTILE DYSFUNCTION

RAGE products

Gene_expression (products) of RAGE associated with reprotox - general 2
11) Confidence 0.19 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 2.33 Pain Relevance 0.10
Further studies are needed to better establish a relationship between RAGE products and ED.


Gene_expression (products) of RAGE associated with reprotox - general 2
12) Confidence 0.17 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.15 Pain Relevance 0
Some of the effects of AGEs are mediated through specific receptors (RAGE) expressed by vascular endothelial, smooth muscle cells and cardiac myocytes.
Gene_expression (expressed) of RAGE in smooth muscle cells
13) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 0.71 Pain Relevance 0
Expression of VCAM-1 results in an increase in monocyte adhesion, while monocytes expressing RAGE are recruited by chemotaxis to sites of AGE accumulation.
Gene_expression (expressing) of RAGE in monocytes associated with adhesions
14) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 0.85 Pain Relevance 0.07
Although research on AGEs in human essential hypertension is scant, in preeclampsia, a hypertensive condition of pregnancy, RAGE expression was increased in vascular tissue (Cooke et al 2003).
Gene_expression (expression) of RAGE associated with hypertension and pre-eclampsia
15) Confidence 0.14 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 1.35 Pain Relevance 0.07
Some of the effects of AGEs are mediated through specific receptors (RAGE) expressed by vascular endothelial, smooth muscle cells and cardiac myocytes.
Gene_expression (expressed) of RAGE in cardiac myocytes
16) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 0.71 Pain Relevance 0

General Comments

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