INT127378

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 31
Disease Relevance 26.36
Pain Relevance 8.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) oxidoreductase activity (Mpo)
lysosome (Mpo)
Anatomy Link Frequency
neutrophils 18
leukocyte 2
microglia 2
macrophages 1
blood 1
Mpo (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 933 100.00 Very High Very High Very High
Inflammatory mediators 19 100.00 Very High Very High Very High
intrathecal 20 99.84 Very High Very High Very High
Inflammatory response 108 98.60 Very High Very High Very High
Paracetamol 14 97.12 Very High Very High Very High
chemokine 70 96.48 Very High Very High Very High
ischemia 22 92.88 High High
metalloproteinase 10 91.36 High High
Analgesic 22 89.40 High High
IPN 2 86.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1065 100.00 Very High Very High Very High
Urological Neuroanatomy 384 100.00 Very High Very High Very High
Disease 187 99.90 Very High Very High Very High
Infection 27 99.72 Very High Very High Very High
Necrosis 28 98.30 Very High Very High Very High
Myocardial Infarction 128 97.92 Very High Very High Very High
Death 51 97.24 Very High Very High Very High
Injury 378 96.08 Very High Very High Very High
Lung Injury 33 95.96 Very High Very High Very High
Pneumonia 6 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we have examined the 'anti-inflammatory effect of IT injection of neostigmine' (AI-NEO) using a standard mouse air pouch model by evaluating the effect of AI-NEO on zymosan-induced leukocyte migration and myeloperoxidase (MPO) release.
Localization (release) of MPO in leukocyte associated with inflammation, urological neuroanatomy and intrathecal
1) Confidence 0.78 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15922370 Disease Relevance 0.69 Pain Relevance 0.78
In the present study, we have examined the 'anti-inflammatory effect of IT injection of neostigmine' (AI-NEO) using a standard mouse air pouch model by evaluating the effect of AI-NEO on zymosan-induced leukocyte migration and myeloperoxidase (MPO) release.
Localization (release) of myeloperoxidase in leukocyte associated with inflammation, urological neuroanatomy and intrathecal
2) Confidence 0.78 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15922370 Disease Relevance 0.70 Pain Relevance 0.79
Determination of myeloperoxidase
Localization (Determination) of myeloperoxidase
3) Confidence 0.74 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.25 Pain Relevance 0
We showed significant inhibitions of MPO release from human stimulated neutrophils by LA, at low concentrations (1 and 10 ?
Localization (release) of MPO in neutrophils associated with urological neuroanatomy
4) Confidence 0.71 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 1.31 Pain Relevance 0.65
Besides, the activity of LA on the MPO release from human neutrophils was also evaluated.
Localization (release) of MPO in neutrophils associated with urological neuroanatomy
5) Confidence 0.71 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.84 Pain Relevance 0.37
In order to evaluate the possible effect of LA on MPO, we determined its effects on the PMA-stimulated MPO release from human neutrophils.
Localization (release) of MPO in neutrophils associated with urological neuroanatomy
6) Confidence 0.71 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.40 Pain Relevance 0.04
MPO is released by activated neutrophils, and is a biomarker for inflammation.
Localization (released) of MPO in neutrophils associated with inflammation and urological neuroanatomy
7) Confidence 0.71 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.85 Pain Relevance 0.38
MPO is a key inflammatory enzyme secreted by activated PMNs and macrophages/microglia, capable of generating highly reactive oxygen species to cause additional damage in various pathological conditions such as cerebral ischemia (Weston et al., 2007; Breckwoldt et al., 2008); ischemic heart conditions (Loria et al., 2008); inflammatory bowel disease (Naito et al., 2007); and kidney (Malle et al., 2003) and lung (Kinnula, 2005) pathologies, among others.
Localization (secreted) of MPO in macrophages associated with inflammation, cv general 4 under development, ischemia and urological neuroanatomy
8) Confidence 0.69 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 1.28 Pain Relevance 0.36
Locally, activated PMNs release antimicrobial and inflammatory mediators, such as MPO, among others.
Localization (release) of MPO in PMNs associated with inflammatory mediators and urological neuroanatomy
9) Confidence 0.69 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 1.21 Pain Relevance 0.35
In our study, the data of peritoneal supernatant MPO levels have demonstrated a significant level of MPO released into the peritoneal cavity in mice subjected to CLP (Figure 4B).
Localization (released) of MPO in peritoneal cavity associated with urological neuroanatomy
10) Confidence 0.69 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.95 Pain Relevance 0.03
This increase may reflect a greater degree of neutrophils activation and/or loss of cell membrane integrity of the P/I null mice, and thereby the release of their MPO into the supernatant.
Localization (release) of MPO in neutrophils associated with urological neuroanatomy
11) Confidence 0.69 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.78 Pain Relevance 0
During stimulation, MPO is secreted by these cells and activates cellular inflammatory signaling cascades [29].
Localization (secreted) of MPO associated with inflammation and urological neuroanatomy
12) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 1.05 Pain Relevance 0.12
If there is a local inflammatory response and PMN infiltration following subretinal delivery of nanoparticles, MPO will be activated and released.
Localization (released) of MPO associated with inflammatory response and urological neuroanatomy
13) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 1.13 Pain Relevance 0.12
Myeloperoxidase (MPO) release from human neutrophils
Localization (release) of Myeloperoxidase in neutrophils associated with urological neuroanatomy
14) Confidence 0.66 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.16 Pain Relevance 0.06
Myeloperoxidase (MPO) release from human neutrophils
Localization (release) of MPO in neutrophils associated with urological neuroanatomy
15) Confidence 0.66 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.16 Pain Relevance 0.06
MPO is an enzyme stored in azurophilic granula of neutrophils, released after their activation and characterized by powerful pro-oxidative and pro-inflammatory proteins [40].
Localization (released) of MPO in neutrophils associated with inflammation and urological neuroanatomy
16) Confidence 0.66 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 1.25 Pain Relevance 0.54
The bacterial count, MPO activity, FITC, glutathione level, and bacterial translocation between groups were assessed with one-way analysis of variance (ANOVA), followed by Scheffe's F test.


Localization (translocation) of MPO associated with urological neuroanatomy
17) Confidence 0.64 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.48 Pain Relevance 0
MPO, released by neutrophil, may attack normal tissue and thus contribute to the pathogenesis disease.
Localization (released) of MPO in neutrophil associated with urological neuroanatomy and disease
18) Confidence 0.64 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.16 Pain Relevance 0.10
Furthermore, the effect of LA on the myeloperoxidase release (MPO, an inflammation biomarker) from human neutrophils was also determined, as well as its antioxidant potential by the DPPH assay.


Localization (release) of myeloperoxidase in neutrophils associated with inflammation and urological neuroanatomy
19) Confidence 0.62 Published 2010 Journal J Inflamm (Lond) Section Abstract Doc Link PMC3019217 Disease Relevance 0.70 Pain Relevance 0.45
LA effects on the myeloperoxidase (MPO) release from human neutrophils in vitro
Localization (release) of myeloperoxidase in neutrophils associated with urological neuroanatomy
20) Confidence 0.62 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.45 Pain Relevance 0.04

General Comments

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