INT127387

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.91
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
spinal cord 3
spinal 2
nucleus 2
DRG 1
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 10 99.98 Very High Very High Very High
intrathecal 2 98.32 Very High Very High Very High
Spinal cord 19 97.32 Very High Very High Very High
Spontaneous pain 2 96.20 Very High Very High Very High
Sciatic nerve 19 96.12 Very High Very High Very High
nMDA receptor 2 95.96 Very High Very High Very High
cytokine 2 95.12 Very High Very High Very High
chemokine 2 94.68 High High
dorsal root ganglion 21 81.44 Quite High
Neuropathic pain 21 78.92 Quite High
Disease Link Frequency Relevance Heat
Injury 13 99.98 Very High Very High Very High
Spinal Injuries 2 98.82 Very High Very High Very High
Pain 13 96.20 Very High Very High Very High
Adhesions 2 93.84 High High
Stress 3 89.80 High High
Apoptosis 1 89.48 High High
Necrosis 8 83.32 Quite High
Cancer 8 82.96 Quite High
Ganglion Cysts 30 81.44 Quite High
Neuropathic Pain 25 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of NF-kappaB in spinal cord associated with eae, spinal cord and intrathecal
1) Confidence 0.38 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.24 Pain Relevance 0.86
Excitotoxic spinal injury resulted in: (1) increased phosphorylation of ERK1/2; (2) increased activation of NF-kB and phosphorylation of ELK-1; and (3) increased gene expression for the NK-1 receptor and NR1 and NR-2A subunits of the NMDA receptor.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of NF-kB in spinal associated with nmda receptor and spinal injuries
2) Confidence 0.35 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15922485 Disease Relevance 0.68 Pain Relevance 0.38
B is phosphorylated and degraded, allowing NF-kappaB to translocate to the nucleus where it binds DNA and triggers the transcription of target genes, such as proinflammatory cytokines, chemokines, and cell adhesion molecules.
Positive_regulation (allowing) of Phosphorylation (phosphorylated) of NF-kappaB in nucleus associated with chemokine, adhesions and cytokine
3) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.75 Pain Relevance 0.48
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Positive_regulation (elevated) of in DRG Phosphorylation (phosphorylation) of NF-kappaB in spinal cord associated with eae, spinal cord and intrathecal
4) Confidence 0.13 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.24 Pain Relevance 0.86

General Comments

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