INT127413

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcna4)
Kcna4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 23 88.40 High High
Root ganglion neuron 1 75.00 Quite High
addiction 1 74.08 Quite High
Action potential 3 55.68 Quite High
nociceptor 1 53.80 Quite High
diclofenac 28 50.84 Quite High
epidural 1 49.92 Quite Low
Lasting pain 1 49.52 Quite Low
cINOD 19 5.00 Very Low Very Low Very Low
hyperexcitability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 24 88.40 High High
Pain 3 49.52 Quite Low
Convulsion 10 33.92 Quite Low
Colon Cancer 7 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Lewis Lung Carcinoma 2 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substituting polar threonines for conserved hydrophobic residues of the S6 segment weakened BAB binding but did not alter the voltage-dependent gating of the Kv4.2 channel.
Neg (not) Regulation (alter) of Kv4
1) Confidence 0.38 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15923341 Disease Relevance 0.44 Pain Relevance 0.31
Except for a moderate inhibition of Kv1.2 and Kv7.1 currents (34% and 23 %, respectively), compound 6 (50 ┬ÁM) did not affect the current amplitude of Kv11.1 (hERG), Kv2.1 and Kv4.3.
Neg (not) Regulation (affect) of Kv4
2) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

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