INT127428

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.26
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
parietal cortex 1
neurons 1
duodenum 1
stomach 1
cortex 1
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 64 100.00 Very High Very High Very High
Pain 43 99.92 Very High Very High Very High
long-term potentiation 87 99.68 Very High Very High Very High
agonist 11 99.32 Very High Very High Very High
dorsal root ganglion 28 98.96 Very High Very High Very High
qutenza 54 98.00 Very High Very High Very High
Dorsal horn 1 95.00 High High
Spinal cord 2 94.52 High High
Hippocampus 24 93.52 High High
Thalamus 6 92.52 High High
Disease Link Frequency Relevance Heat
Pain 33 99.92 Very High Very High Very High
Ganglion Cysts 29 98.96 Very High Very High Very High
Herpes Simplex Virus Infection 7 97.56 Very High Very High Very High
Post Operative Pain 7 95.52 Very High Very High Very High
Cancer 86 94.00 High High
Herpes Simplex Virus 2 92.88 High High
Peptic Ulcer 2 92.84 High High
Targeted Disruption 63 92.80 High High
Herpes Zoster 1 88.68 High High
Pancreatic Cancer 84 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deficiency in EP3 but not EP1, IP or TP prostanoid receptor markedly diminished the acute herpetic pain and resulted in the decrease of the incidence of the delayed postherpetic pain.
Negative_regulation (Deficiency) of EP1 associated with pain, post operative pain and herpes simplex virus infection
1) Confidence 0.42 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15925391 Disease Relevance 1.64 Pain Relevance 1.11
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Negative_regulation (inhibition) of EP1 in duodenum
2) Confidence 0.41 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.38 Pain Relevance 0.36
Oppositely, heat pain sensitivity was increased in FP, EP1 and EP1+3 double mutant mice possibly due to a loss of FP or EP1 receptor mediated central control of thermal pain sensitivity.
Negative_regulation (loss) of EP1 associated with pain
3) Confidence 0.36 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938093 Disease Relevance 1.32 Pain Relevance 0.99
To examine the involvement of EP1 in PGE2 (1.5 min)-induced potentiation of capsaicin-evoked response in native neurons, we used a specific EP1 agonist, ONO-DI-004 [27], and a specific EP1 antagonist, ONO-8713 [28], in mouse DRG neurons.
Negative_regulation (antagonist) of EP1 in neurons associated with dorsal root ganglion, qutenza, antagonist and agonist
4) Confidence 0.31 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.10 Pain Relevance 0.69
However, a recent study showed that the levels of EP1 mRNA are the highest in the parietal cortex and cerebellum and that the protein level of EP1 is high in cerebellum (Candelario-Jalil et al. 2005).
Negative_regulation (level) of EP1 in cerebellum
5) Confidence 0.19 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.17
We found that both EP2 and EP3, but not EP1 or EP4, are involved in the LTP in the visual cortex.


Negative_regulation (involved) of EP1 in cortex associated with long-term potentiation
6) Confidence 0.18 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.06 Pain Relevance 0.14
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Negative_regulation (inhibition) of EP1 in stomach
7) Confidence 0.14 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.38 Pain Relevance 0.36
PGE2 receptors are a family of G-protein-coupled receptors, namely, EP1, EP2, EP3, and EP4 [68].
Negative_regulation (family) of EP1
8) Confidence 0.09 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.24 Pain Relevance 0.03
However, a recent study showed that the levels of EP1 mRNA are the highest in the parietal cortex and cerebellum and that the protein level of EP1 is high in cerebellum (Candelario-Jalil et al. 2005).
Negative_regulation (level) of EP1 in parietal cortex
9) Confidence 0.06 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.17
PGE2 exerts its autocrine/paracrine action by binding to either of four main subtypes of GPCR (EP1, EP2, EP3 and EP4) to mobilize intracellular calcium and inositol 1,4,5-trisphosphate (InsP) via Gq/11 (EP1/EP3) or increase cAMP accumulation via G?
Negative_regulation (subtypes) of EP1
10) Confidence 0.05 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.13 Pain Relevance 0.13

General Comments

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