INT127432

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 11.01
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Nup62) nuclear envelope (Nup62) cell death (Nup62)
cytoskeleton (Nup62) nucleus (Nup62) cytoplasm (Nup62)
Anatomy Link Frequency
pancreas 2
osteoclast 2
hepatocytes 1
pancreatic beta cells 1
beta cell 1
Nup62 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 5 97.64 Very High Very High Very High
Nerve growth factor 36 85.88 High High
fibrosis 40 81.92 Quite High
Bile 15 78.36 Quite High
alcohol 15 41.76 Quite Low
cytokine 28 10.96 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
Paracetamol 20 5.00 Very Low Very Low Very Low
rheumatoid arthritis 18 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 459 100.00 Very High Very High Very High
Neuroendocrine Cancer 10 99.84 Very High Very High Very High
Insulinoma 5 99.80 Very High Very High Very High
Glucagonoma 5 99.28 Very High Very High Very High
Liver Disease 75 98.56 Very High Very High Very High
Disease 243 97.96 Very High Very High Very High
Pancreatitis 5 97.64 Very High Very High Very High
Cancer 16 97.60 Very High Very High Very High
Carcinoma 5 96.52 Very High Very High Very High
Stress 98 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
p62 protein is expressed in pancreatic beta cells.
Gene_expression (expressed) of p62 in pancreatic beta cells
1) Confidence 0.71 Published 2005 Journal J. Pathol. Section Title Doc Link 15926199 Disease Relevance 0.59 Pain Relevance 0.07
Here we report that p62 and insulin are co-expressed in a diffuse fashion in beta cells in normal human pancreas as well as in primary chronic pancreatitis and in normal pancreas from mouse and swine.
Gene_expression (co-expressed) of p62 in pancreas associated with chronic pancreatitis
2) Confidence 0.71 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15926199 Disease Relevance 0.69 Pain Relevance 0.10
Since p62 may also be involved in pro-apototic signal transduction, the loss of p62 expression in neuroendocrine neoplasms of the pancreas may render the tumour cells less sensitive to pro-apototic signals.
Gene_expression (expression) of p62 in pancreas associated with neuroendocrine cancer and cancer
3) Confidence 0.71 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15926199 Disease Relevance 0.80 Pain Relevance 0.08
Although the biological function of p62 in beta cells is unknown, the co-expression of p62 and insulin in non-neoplastic beta cells suggests that, in the beta cell, p62 may play a role in specific insulin-related signalling.
Gene_expression (co-expression) of p62 in beta cell
4) Confidence 0.71 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15926199 Disease Relevance 0.83 Pain Relevance 0.09
In contrast, p62 protein is absent from, or only focally and very weakly expressed in, insulinomas, glucagonomas or non-functioning pancreatic neuroendocrine tumours or carcinomas that express insulin or other pancreatic as well as extrapancreatic hormones.
Neg (absent) Gene_expression (expressed) of p62 associated with neuroendocrine cancer, glucagonoma, carcinoma and insulinoma
5) Confidence 0.61 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15926199 Disease Relevance 0.87 Pain Relevance 0.10
Preliminary genotype/phenotype analyses support the significance of p62-mediated ubiquitin binding in osteoclast homeostasis and further verify the existence of a causal relationship between p62 mutations and PDB [33].
Gene_expression (mutations) of p62 in osteoclast associated with bone disease
6) Confidence 0.53 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.34 Pain Relevance 0
Finally, two separate groups have shown that under certain conditions, ectopic expression of PDB mutant p62 evokes more efficient activation of NF-?
Gene_expression (mutant) of p62 associated with bone disease
7) Confidence 0.53 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.68 Pain Relevance 0
Certainly, the expression levels of p62 directly influence signalling; depletion of p62 in cultured cells severely inhibits NF-?
Gene_expression (expression) of p62
8) Confidence 0.53 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.35 Pain Relevance 0
The precise mechanism by which p62 mutations result in disordered RANK-NF-?
Gene_expression (mutations) of p62
9) Confidence 0.53 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.41 Pain Relevance 0
Finally, two separate groups have shown that under certain conditions, ectopic expression of PDB mutant p62 evokes more efficient activation of NF-?
Gene_expression (expression) of p62 associated with bone disease
10) Confidence 0.53 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.78 Pain Relevance 0
This observation is somewhat at variance with the finding that a p62 construct carrying the most common P392L PDB missense mutation, and which causes loss of ubiquitin binding of p62 [31], apparently evokes more efficient activation of NF-?
Gene_expression (construct) of p62 associated with bone disease
11) Confidence 0.53 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.46 Pain Relevance 0.09
However, a more recent study also using reporter assays noted that although PDB mutant p62 constructs activated NF-?
Gene_expression (constructs) of p62 associated with bone disease
12) Confidence 0.53 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.48 Pain Relevance 0.07
RAW264.7 or monocytes) carrying PDB mutant p62 into OLCs [21,22] represent potential assay systems for developing high-throughput screens for the identification of lead compounds which may be useful in correcting disordered osteoclast NF-?
Gene_expression (carrying) of p62 in osteoclast associated with bone disease
13) Confidence 0.46 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.58 Pain Relevance 0
Furthermore, p62 inhibition attenuated, whereas p62 overexpression enhanced MDB formation in DDC-primed hepatocytes (Nan et al. 2006).
Gene_expression (overexpression) of p62 in hepatocytes
14) Confidence 0.44 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.07 Pain Relevance 0
MDBs also arise in cell culture after transfection with K8/K18, ubiquitin, and p62.
Gene_expression (transfection) of p62
15) Confidence 0.44 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386529 Disease Relevance 1.01 Pain Relevance 0.04
A recent study noted, however, that in reporter assays, over-expression of wild-type p62 attenuated (rather than potentiated) NF-?
Gene_expression (over-expression) of p62
16) Confidence 0.41 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.40 Pain Relevance 0
Immunohistochemical staining with p62 antibody visualizes the presence of multiple irregularly shaped aggregates in patients with alcoholic steatohepatitis (a), non-alcoholic steatohepatitis (b), Indian childhood cirrhosis and (c), idiopathic copper toxicosis (d)
Gene_expression (antibody) of p62 associated with cirrhosis
17) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.02 Pain Relevance 0
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Gene_expression (expression) of p62
18) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.23 Pain Relevance 0.08
In cell culture experiments, protein aggregates resembling MDBs formed only after p62 co-transfection, but not when K8, K18, and ubiquitin were transfected alone or in combination (Stumptner et al. 2007).
Gene_expression (transfection) of p62
19) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.12 Pain Relevance 0
10 results in increased levels of ubiquitin and p62 and inhibition of protein degradation through the process of autophagy [13].
Gene_expression (levels) of p62
20) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.29 Pain Relevance 0

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