INT127433

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.36
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Nup62) nuclear envelope (Nup62) cell death (Nup62)
cytoskeleton (Nup62) nucleus (Nup62) cytoplasm (Nup62)
Anatomy Link Frequency
pancreas 2
Nup62 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 75.96 Quite High
Nerve growth factor 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 102 100.00 Very High Very High Very High
Neuroendocrine Cancer 2 99.84 Very High Very High Very High
Cancer 1 97.60 Very High Very High Very High
Carcinoma 1 84.96 Quite High
Glucagonoma 1 82.28 Quite High
Insulinoma 1 81.72 Quite High
Syndrome 18 77.32 Quite High
Pancreatitis 1 75.96 Quite High
Hypercalcemia 8 70.40 Quite High
Disease 32 68.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since p62 may also be involved in pro-apototic signal transduction, the loss of p62 expression in neuroendocrine neoplasms of the pancreas may render the tumour cells less sensitive to pro-apototic signals.
Negative_regulation (loss) of Gene_expression (expression) of p62 in pancreas associated with neuroendocrine cancer and cancer
1) Confidence 0.53 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15926199 Disease Relevance 0.80 Pain Relevance 0.08
Finally, two separate groups have shown that under certain conditions, ectopic expression of PDB mutant p62 evokes more efficient activation of NF-?
Negative_regulation (evokes) of Gene_expression (expression) of p62 associated with bone disease
2) Confidence 0.33 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.78 Pain Relevance 0
Finally, two separate groups have shown that under certain conditions, ectopic expression of PDB mutant p62 evokes more efficient activation of NF-?
Negative_regulation (ectopic) of Gene_expression (expression) of p62 associated with bone disease
3) Confidence 0.33 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.78 Pain Relevance 0

General Comments

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