INT127452

Context Info Confidence 0.32 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.88 Pain Relevance 0.87

embryo development (CDK5) cytoplasm (CDK5) cell proliferation (CDK5) cytosol (CDK5) nucleocytoplasmic transport (CDK5) cell death (CDK5)

Anatomy Link Frequency central nervous system 2 CDK5 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 38 100.00 Analgesic 6 100.00 Central nervous system 33 98.48 Neuritis 3 89.28 agonist 26 86.60 Arthritis 5 5.00 Inflammatory mediators 4 5.00 antagonist 4 5.00 cerebral cortex 3 5.00 cytokine 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 45 100.00 Nervous System Malformation 27 98.16 Convulsion 3 95.88 Cognitive Disorder 12 95.32 Neurodegenerative Disease 33 94.36 Neuritis 3 89.28 Cancer 20 80.32 Hyperplasia 1 78.44 Attention Deficit Hyperactivity Disorder 6 57.68 Disease 17 44.08

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Anatomy

Negation

Speculation

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CDK5R1 (Cyclin-dependent kinase 5 regulatory subunit 1) encodes for p35, a protein required for the activation of cyclin-dependent kinase 5 (CDK5), whose activity plays a key role in central nervous system development [1].

Positive_regulation (activation) of cyclin-dependent kinase 5 in central nervous system associated with nervous system malformation and central nervous system

1) Confidence 0.32 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.38 Pain Relevance 0.09

The absence of p39 did not produce aberrant phenotype, indicating a predominant role of p35 in CDK5 activation [7].

Positive_regulation (activation) of CDK5

2) Confidence 0.32 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.62 Pain Relevance 0.19

CDK5R1 (Cyclin-dependent kinase 5 regulatory subunit 1) encodes for p35, a protein required for the activation of cyclin-dependent kinase 5 (CDK5), whose activity plays a key role in central nervous system development [1].

Positive_regulation (activation) of CDK5 in central nervous system associated with nervous system malformation and central nervous system

3) Confidence 0.32 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.38 Pain Relevance 0.09

This data suggests that PAR2 regulates the cell cycle at the transcriptional level, modulating the expression of a number of important genes including crucial regulators of cell cycle transitions such as the cyclin family (CCNA1, CCNF, CCNYL1) and cyclin-dependent kinases (CDK5, CDK10).

Positive_regulation (dependent) of CDK5

4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.24 Pain Relevance 0.10

These compounds were screened for anti-inflammatory, analgesic and kinase (CDK1, CDK5 and GSK3) inhibition activities.

Positive_regulation (screened) of CDK5 associated with inflammation and analgesic

5) Confidence 0.08 Published 2005 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15927836 Disease Relevance 0.27 Pain Relevance 0.40

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