INT127455

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 5.62
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
adult heart 4
artery smooth muscle 4
plasma 2
pulmonary artery 2
hippocampus 2
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 48 100.00 Very High Very High Very High
fluoxetine 46 99.70 Very High Very High Very High
Hippocampus 33 98.36 Very High Very High Very High
sSRI 24 95.84 Very High Very High Very High
Inflammation 7 95.36 Very High Very High Very High
depression 93 91.24 High High
antidepressant 117 85.36 High High
antagonist 67 84.00 Quite High
bDMF 32 72.88 Quite High
Eae 23 68.48 Quite High
Disease Link Frequency Relevance Heat
Shock 5 99.98 Very High Very High Very High
Manic Depressive Disorder 3 99.96 Very High Very High Very High
Hyperplasia 4 99.76 Very High Very High Very High
Pulmonary Hypertension 256 99.60 Very High Very High Very High
Urological Neuroanatomy 10 99.52 Very High Very High Very High
Hypertension 20 99.34 Very High Very High Very High
Hypoxia 10 99.32 Very High Very High Very High
INFLAMMATION 10 95.36 Very High Very High Very High
Hypertrophy 41 93.76 High High
Depression 100 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Progression of pulmonary hypertension (PH) is associated with increased lung expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the pulmonary artery smooth muscle cells (PA-SMCs).
Positive_regulation (increased) of Gene_expression (expression) of serotonin transporter in artery smooth muscle associated with hypertension, serotonin and hyperplasia
1) Confidence 0.59 Published 2005 Journal Circulation Section Abstract Doc Link 15927991 Disease Relevance 0.54 Pain Relevance 0.21
BACKGROUND: Progression of pulmonary hypertension (PH) is associated with increased lung expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the pulmonary artery smooth muscle cells (PA-SMCs).
Positive_regulation (increased) of Gene_expression (expression) of 5-HTT in artery smooth muscle associated with hypertension, serotonin and hyperplasia
2) Confidence 0.37 Published 2005 Journal Circulation Section Abstract Doc Link 15927991 Disease Relevance 0.54 Pain Relevance 0.21
Although the expression profile of 5-HTT in late fetal and neonatal heart seems to be independent of the reference gene used, the estimated 5-HTT expression in the adult heart differs significantly with the choice of reference gene (Figure 3B).
Neg (independent) Positive_regulation (independent) of Gene_expression (expression) of 5-HTT in adult heart
3) Confidence 0.35 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.20 Pain Relevance 0.13
Although the expression profile of 5-HTT in late fetal and neonatal heart seems to be independent of the reference gene used, the estimated 5-HTT expression in the adult heart differs significantly with the choice of reference gene (Figure 3B).
Positive_regulation (estimated) of Gene_expression (expression) of 5-HTT in adult heart
4) Confidence 0.35 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.21 Pain Relevance 0.12
CONCLUSIONS: Upregulation of lung 5-HTT induced by MCT appears necessary to initiate the development of pulmonary vascular remodeling, whereas a sustained increase in 5-HTT expression may underlie both the progression and the maintenance of MCT-induced PH.
Positive_regulation (increase) of Gene_expression (expression) of 5-HTT in lung
5) Confidence 0.34 Published 2005 Journal Circulation Section Body Doc Link 15927991 Disease Relevance 0 Pain Relevance 0
In contrast, normalization of 5-HTT to Gapdh indicated only a transient increase in 5-HTT expression.


Positive_regulation (increase) of Gene_expression (expression) of 5-HTT
6) Confidence 0.33 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.67 Pain Relevance 0.05
Normalization of the serotonin transporter 5-HTT (Slc6a4, SERT) mRNA to Rpl4 suggested that 5-HTT expression increased with developmental stage.
Positive_regulation (increased) of Gene_expression (expression) of 5-HTT in developmental stage associated with serotonin
7) Confidence 0.33 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.59 Pain Relevance 0.05
Similarly, in studies on patients with bipolar disorder, 5-HTT levels have been found to be increased in medial prefrontal cortex, but not in hippocampus (Cannon et al., 2006).
Positive_regulation (increased) of Gene_expression (levels) of 5-HTT in hippocampus associated with manic depressive disorder and hippocampus
8) Confidence 0.30 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.26 Pain Relevance 0.13
Fluoxetine significantly increased the number of lymphocytes expressing serotonin transporter and elevated the binding of [(3)H]paroxetine.
Positive_regulation (increased) of Gene_expression (expressing) of serotonin transporter in lymphocytes associated with serotonin and fluoxetine
9) Confidence 0.24 Published 2009 Journal Int. Immunopharmacol. Section Abstract Doc Link 19189865 Disease Relevance 0.19 Pain Relevance 1.01
Progression of PAH is associated with increased pulmonary expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the pulmonary artery SMCs (PA-SMCs).
Positive_regulation (increased) of Gene_expression (expression) of serotonin transporter in pulmonary artery associated with pulmonary hypertension, serotonin and hyperplasia
10) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.99 Pain Relevance 0.42
Repetitive electro-convulsive shock increases 5-HTT protein expression in the rat frontal cortex probably as a compensatory mechanism against the enhanced ECS induced 5-HT release in presynaptic terminals [274].
Positive_regulation (increases) of Gene_expression (expression) of 5-HTT in frontal cortex associated with shock and urological neuroanatomy
11) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.49 Pain Relevance 0.51
Research has found that patients with PAH have increased plasma serotonin levels,118 and that over-expression of the serotonin transporter gene (SERT) increases PA pressure.119 Hypoxia and monocrotaline-induced PAH in animals has been shown to be inhibited by the selective serotonin reuptake inhibitor (SSRI), fluoxetine.120,121 So far however, studies in humans have not produced statistically significant results.122

l-Arginine

Positive_regulation (increases) of Gene_expression (expression) of serotonin transporter gene in plasma associated with pulmonary hypertension, hypoxia, ssri, serotonin and fluoxetine
12) Confidence 0.03 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.93 Pain Relevance 0.38

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