INT127458

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 27.25
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAH) small molecule metabolic process (PAH) cellular nitrogen compound metabolic process (PAH)
Anatomy Link Frequency
plasma 3
lung 2
monocyte 1
mesenteric lymph nodes 1
capillary 1
PAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 219 99.44 Very High Very High Very High
fluoxetine 3 99.22 Very High Very High Very High
Inflammatory mediators 20 98.96 Very High Very High Very High
cytokine 59 98.92 Very High Very High Very High
antagonist 250 98.76 Very High Very High Very High
ischemia 38 98.56 Very High Very High Very High
Inflammatory response 67 97.20 Very High Very High Very High
potassium channel 4 91.20 High High
imagery 12 88.64 High High
Serotonin 8 88.20 High High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 776 100.00 Very High Very High Very High
Hypoxia 549 100.00 Very High Very High Very High
Pressure And Volume Under Development 269 100.00 Very High Very High Very High
Hypertension 175 100.00 Very High Very High Very High
Primary Pulmonary Hypertension 96 100.00 Very High Very High Very High
Pheochromocytoma 50 100.00 Very High Very High Very High
Phenylketonuria 8 100.00 Very High Very High Very High
Hepatic Insufficiency 6 100.00 Very High Very High Very High
Myocardial Infarction 17 99.88 Very High Very High Very High
Gallstones 32 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicated that 12 genes were significantly up-regulated in PKU.
Positive_regulation (up-regulated) of PKU associated with phenylketonuria
1) Confidence 0.58 Published 2005 Journal Mol. Genet. Metab. Section Abstract Doc Link 16150627 Disease Relevance 1.20 Pain Relevance 0.13
Of course, this age-related concept does not concern all types of PH (such as PH in the newborn and probably fenfluramine-induced PH, [3]).
Positive_regulation (induced) of PH associated with pulmonary hypertension
2) Confidence 0.57 Published 2006 Journal Respir Res Section Body Doc Link PMC1764736 Disease Relevance 2.15 Pain Relevance 0
According to the World Health Organization Revised Clinical Classification of Venice (Simonneau et al 2004), pulmonary arterial hypertension (PAH) is a specific subtype of PH with a pulmonary capillary wedge pressure (PCWP) ?
Positive_regulation (hypertension) of PAH in capillary associated with pulmonary hypertension
3) Confidence 0.38 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 1.62 Pain Relevance 0.06
DHEA prevented hypoxic PH in old age
Positive_regulation (hypoxic) of PH associated with pulmonary hypertension and hypoxia
4) Confidence 0.36 Published 2006 Journal Respir Res Section Body Doc Link PMC1764736 Disease Relevance 1.76 Pain Relevance 0.05
Hypoxia induced PH in old mice and DHEA prevented it. 2.
Positive_regulation (induced) of PH associated with pulmonary hypertension and hypoxia
5) Confidence 0.33 Published 2006 Journal Respir Res Section Body Doc Link PMC1764736 Disease Relevance 1.59 Pain Relevance 0
Since heart failure does occur in human PH, this brings into question today's development of PH therapies and their specific long-term global effects in laboratory animals.
Positive_regulation (occur) of PH in heart associated with pulmonary hypertension and myocardial infarction
6) Confidence 0.33 Published 2006 Journal Respir Res Section Body Doc Link PMC1764736 Disease Relevance 1.86 Pain Relevance 0
For example, in monocrotaline-induced PH, both the selective ETA blocker (darusentan 50 mg/kg/day) and the dual ETA and ETB antagonist (BSF-420627, 50 mg/kg/day) were effective in decreasing the severity of PH.
Positive_regulation (induced) of PH associated with antagonist
7) Confidence 0.27 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.43 Pain Relevance 0.16
Despite these limitations, studies have established that plasma ET-1 levels are increased in PAH and that pulmonary expression and release of ET-1 is increased in PAH (Stewart et al 1991).
Positive_regulation (increased) of PAH in plasma associated with pulmonary hypertension
8) Confidence 0.24 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.54 Pain Relevance 0.09
Despite these limitations, studies have established that plasma ET-1 levels are increased in PAH and that pulmonary expression and release of ET-1 is increased in PAH (Stewart et al 1991).
Positive_regulation (increased) of PAH in plasma associated with pulmonary hypertension
9) Confidence 0.24 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.53 Pain Relevance 0.09
Of 192 patients referred for the preoperative work-up of a first PH or PGL, 20 (10%) had bilateral PH and 25 had PGL (13%).
Positive_regulation (had) of PH associated with paraganglioma and pheochromocytoma
10) Confidence 0.21 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.17 Pain Relevance 0.53
Of note, ET-1 plasma levels correlate with parameters of pulmonary haemodynamics,12 and predict survival in patients with untreated PAH.13
Positive_regulation (untreated) of PAH in plasma associated with pulmonary hypertension
11) Confidence 0.20 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.73 Pain Relevance 0.04
For ambrisentan, comparable efficacy with respect to functional capacity, measured as 6MWD, was described for 19 patients (30%) with PAH associated with collagen vascular disease, when compared to patients with idiopathic PAH.73
Positive_regulation (idiopathic) of PAH associated with pulmonary hypertension and hypersensitivity vasculitis
12) Confidence 0.20 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 1.32 Pain Relevance 0
Whether or not the effects of ERAs on right ventricular hypertrophic responses in monocrotaline-induced PH are reproducible in patients with PAH remains to be established.
Positive_regulation (induced) of PH associated with pulmonary hypertension and antagonist
13) Confidence 0.20 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.49 Pain Relevance 0.20
MCT-induced PH was also associated with increased expression of various cytokines, but only interleukin-1beta and monocyte chemotactic protein-1 increased at the early phase and stimulated 5-HTT expression by cultured PA-SMCs.
Positive_regulation (induced) of PH in monocyte
14) Confidence 0.20 Published 2005 Journal Circulation Section Body Doc Link 15927991 Disease Relevance 0 Pain Relevance 0
In 6 (46.2%) of the 13 patients clinical worsening of PAH was defined as an increase in the dose of diuretic.
Positive_regulation (increase) of PAH associated with pulmonary hypertension
15) Confidence 0.16 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.64 Pain Relevance 0
Given the postulated causal relation between 5-HTT overexpression and PH, we herein investigated whether the highly selective 5-HTT inhibitor fluoxetine prevented and/or reversed PH induced by monocrotaline (MCT) in rats.
Spec (whether) Positive_regulation (induced) of PH associated with hypertension and fluoxetine
16) Confidence 0.12 Published 2005 Journal Circulation Section Abstract Doc Link 15927991 Disease Relevance 0.53 Pain Relevance 0.23
CONCLUSIONS: Upregulation of lung 5-HTT induced by MCT appears necessary to initiate the development of pulmonary vascular remodeling, whereas a sustained increase in 5-HTT expression may underlie both the progression and the maintenance of MCT-induced PH.
Positive_regulation (induced) of PH in lung
17) Confidence 0.12 Published 2005 Journal Circulation Section Body Doc Link 15927991 Disease Relevance 0 Pain Relevance 0
Our study suggests that ACE2 activation or administration in experimental PAH [5,6] may be applicable as a therapy for PAH or persistent digital ischemia in patients with CTD.


Positive_regulation (activation) of PAH associated with pulmonary hypertension, ischemia and disease
18) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 1.67 Pain Relevance 0.14
mice, with more pronounced induction of PH and PT mRNA in mPPAR?
Positive_regulation (induction) of PH
19) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.19 Pain Relevance 0
Obstructive cholestasis, which causes chronic hepatic insufficiency and PH with ascites, is a very useful experimental model for studying these complications.
Positive_regulation (causes) of PH associated with pressure and volume under development, hepatic insufficiency and gallstones
20) Confidence 0.03 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2990101 Disease Relevance 1.66 Pain Relevance 0.04

General Comments

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