INT127460

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.30
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAH) small molecule metabolic process (PAH) cellular nitrogen compound metabolic process (PAH)
Anatomy Link Frequency
smooth muscle 2
capillary 2
heart 2
PAH (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 1 97.68 Very High Very High Very High
Serotonin 2 93.32 High High
antagonist 58 93.28 High High
Pain 8 58.64 Quite High
cva 22 57.20 Quite High
agonist 4 48.00 Quite Low
tolerance 11 41.88 Quite Low
headache 11 33.00 Quite Low
Inflammation 15 5.00 Very Low Very Low Very Low
bradykinin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 318 100.00 Very High Very High Very High
Hypertension 14 100.00 Very High Very High Very High
Hyperplasia 3 95.24 Very High Very High Very High
Coronary Heart Disease 3 90.96 High High
Disease 41 88.48 High High
Cv General 4 Under Development 22 87.04 High High
Eisenmenger Complex 2 83.12 Quite High
Hemoglobinopathy 2 82.00 Quite High
Heart Defects 6 81.80 Quite High
Increased Venous Pressure Under Development 49 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to the World Health Organization Revised Clinical Classification of Venice (Simonneau et al 2004), pulmonary arterial hypertension (PAH) is a specific subtype of PH with a pulmonary capillary wedge pressure (PCWP) ?
Positive_regulation (hypertension) of Gene_expression (subtype) of PH in capillary associated with pulmonary hypertension
1) Confidence 0.43 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 1.69 Pain Relevance 0.06
The first published trial of inhaled treprostinil in humans characterized its effects in three patients with severe PAH.74 After right heart catheterization, each patient received a single administration of 15 ?
Positive_regulation (severe) of Gene_expression (severe) of PAH in heart associated with pulmonary hypertension
2) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.52 Pain Relevance 0.06
Combination therapy in PAH
Positive_regulation (therapy) of Gene_expression (therapy) of PAH associated with pulmonary hypertension
3) Confidence 0.38 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 0.98 Pain Relevance 0
A total PAH concentration (normalized to a mass concentration of 300 ?
Positive_regulation (normalized) of Gene_expression (concentration) of PAH
4) Confidence 0.29 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2918524 Disease Relevance 0 Pain Relevance 0
Two studies have demonstrated increased pulmonary vascular smooth muscle expression of ETB in human PAH (Bauer et al 2002; Davie et al 2002).
Positive_regulation (increased) of Gene_expression (expression) of PAH in smooth muscle associated with pulmonary hypertension
5) Confidence 0.24 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.56 Pain Relevance 0.16
Given the postulated causal relation between 5-HTT overexpression and PH, we herein investigated whether the highly selective 5-HTT inhibitor fluoxetine prevented and/or reversed PH induced by monocrotaline (MCT) in rats.
Spec (postulated) Positive_regulation (overexpression) of Gene_expression (overexpression) of PH associated with hypertension and fluoxetine
6) Confidence 0.14 Published 2005 Journal Circulation Section Abstract Doc Link 15927991 Disease Relevance 0.55 Pain Relevance 0.22

General Comments

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