INT127462

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.35
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAH) small molecule metabolic process (PAH) cellular nitrogen compound metabolic process (PAH)
PAH (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 17 89.84 High High
potassium channel 1 89.24 High High
Pain 1 70.64 Quite High
headache 6 70.12 Quite High
tolerance 6 62.40 Quite High
Serotonin 2 50.00 Quite Low
Potency 1 44.80 Quite Low
Calcium channel 5 33.16 Quite Low
nud 3 12.72 Low Low
cva 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 229 100.00 Very High Very High Very High
Hypoxia 90 98.32 Very High Very High Very High
Disease 25 96.24 Very High Very High Very High
Death 37 86.60 High High
Thrombosis 9 77.88 Quite High
Infection 2 77.40 Quite High
Pain 1 70.64 Quite High
Headache 5 70.12 Quite High
Pressure Volume 2 Under Development 4 69.72 Quite High
Increased Venous Pressure Under Development 20 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacology and acute effects of sildenafil in PH
Regulation (effects) of PH associated with pulmonary hypertension
1) Confidence 0.39 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994020 Disease Relevance 0.73 Pain Relevance 0.22
Advocates of targets in PAH therapy would include FC II status as a clear goal.
Regulation (targets) of PAH associated with pulmonary hypertension
2) Confidence 0.20 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.85 Pain Relevance 0.03
No previous study reported effects of DHEA on PH in old age.
Regulation (effects) of PH associated with pulmonary hypertension
3) Confidence 0.19 Published 2006 Journal Respir Res Section Body Doc Link PMC1764736 Disease Relevance 1.76 Pain Relevance 0.04
The 5-HT receptor antagonists did not affect PH.
Neg (not) Regulation (affect) of PH
4) Confidence 0.11 Published 2005 Journal Circulation Section Body Doc Link 15927991 Disease Relevance 0 Pain Relevance 0
In conclusion, these results suggested that PLD4 is a HKD motif-containing protein family member that lacks authentic PLD activity, which is most likely due to structural alterations in PX/PH domains and HKD motifs critical for enzymatic activity.
Regulation (alterations) of PH
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0

General Comments

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