INT127463

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.30
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAH) small molecule metabolic process (PAH) cellular nitrogen compound metabolic process (PAH)
PAH (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 1 99.40 Very High Very High Very High
antagonist 1 93.92 High High
potassium channel 1 91.60 High High
Serotonin 2 88.56 High High
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 77 100.00 Very High Very High Very High
Pulmonary Hypertension 49 100.00 Very High Very High Very High
Hypertension 5 99.98 Very High Very High Very High
Hyperplasia 1 90.48 High High
Death 32 74.20 Quite High
Weight Loss 7 67.60 Quite High
Erythrocytosis 3 34.08 Quite Low
Frailty 5 13.36 Low Low
Lifespan 14 5.00 Very Low Very Low Very Low
Pulmonary Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DHEA prevented hypoxic PH in old age
Negative_regulation (prevented) of Positive_regulation (hypoxic) of PH associated with pulmonary hypertension and hypoxia
1) Confidence 0.30 Published 2006 Journal Respir Res Section Body Doc Link PMC1764736 Disease Relevance 1.77 Pain Relevance 0.05
Given the postulated causal relation between 5-HTT overexpression and PH, we herein investigated whether the highly selective 5-HTT inhibitor fluoxetine prevented and/or reversed PH induced by monocrotaline (MCT) in rats.
Spec (whether) Negative_regulation (reversed) of Spec (whether) Positive_regulation (induced) of PH associated with hypertension and fluoxetine
2) Confidence 0.11 Published 2005 Journal Circulation Section Abstract Doc Link 15927991 Disease Relevance 0.54 Pain Relevance 0.23

General Comments

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