INT12747

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Context Info
Confidence 0.21
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.18
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
striatum 4
granule cells 2
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 9 100.00 Very High Very High Very High
Enkephalin 13 94.08 High High
Hippocampus 3 94.08 High High
corticosteroid 24 78.40 Quite High
Cholecystokinin 1 77.28 Quite High
Central nervous system 1 75.00 Quite High
dexamethasone 5 47.32 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 90.16 High High
Thyroid Disease 1 89.94 High High
Insulin Resistance 20 50.00 Quite Low
Diabetes Mellitus 5 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Metabolic Syndrome 2 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the striatum, preproenkephalin mRNA abundance linearly increased 8-fold from day 5-43, while a transient increase in the preprocholecystokinin mRNA abundance between days 10 and 20 was noted.
Positive_regulation (increase) of Transcription (abundance) of preprocholecystokinin mRNA in striatum
1) Confidence 0.21 Published 1988 Journal Brain Res. Section Abstract Doc Link 3219577 Disease Relevance 0.09 Pain Relevance 0.08
Quantitation by solution hybridization reveals that in the hamster the highest levels of PPenk mRNA are found in adrenal (16.3 +/- 1.4 pg equivalents/micrograms RNA (mean +/- S.E.M.)) and striatum (13.3 +/- 0.7), followed by hypothalamus (0.8 +/- 0.2), and hippocampus (0.4 +/- 0.2).
Positive_regulation (levels) of Transcription (found) of PPenk mRNA in striatum associated with hippocampus
2) Confidence 0.07 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1653391 Disease Relevance 0 Pain Relevance 0.28
Our results can be summarized as follows: (1) hypothyroidism induces an up-regulation of ENK mRNA in the granule cells of the dentate gyrus and layers V/VI of the cingulate cortex and of DYN mRNA in the granule cells of the dentate gyrus; (2) the up-regulation of ENK mRNA expression in the granule cells induced by KA is not modified by altered thyroid status; (3) in contrast, the KA injection fails to up-regulate DYN precursor mRNA expression in the granule cells of the rostral dentate gyrus of the hypothyroid rats; (4) injection of KA in hyperthyroid rats increases the expression of DYN mRNA in the granule dentate gyrus more than in euthyroid rats.
Positive_regulation (increases) of Transcription (expression) of DYN mRNA in granule cells associated with dynorphin, thyroid disease and enkephalin
3) Confidence 0.04 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583317 Disease Relevance 0.09 Pain Relevance 0.92
The enhancement of gene transcription is dependent on DR(N) with a maximum stimulatory effect (Smax_IL6R1m) and SC50_IL6R1m is the concentration of DR(N) that leads to 50% of maximum stimulation of mRNA transcription.
Positive_regulation (stimulation) of Transcription (transcription) of mRNA
4) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.07

General Comments

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