INT127496

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.66
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
primary somatosensory cortex 2
striatum 2
caudate putamen 2
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 99.78 Very High Very High Very High
Hippocampus 19 99.76 Very High Very High Very High
primary somatosensory cortex 2 98.52 Very High Very High Very High
mu opioid receptor 2 92.32 High High
Nucleus accumbens 47 79.20 Quite High
dopamine receptor 1 72.48 Quite High
antagonist 2 71.04 Quite High
Eae 8 50.36 Quite High
antidepressant 1 46.08 Quite Low
fluoxetine 1 44.88 Quite Low
Disease Link Frequency Relevance Heat
Repression 268 100.00 Very High Very High Very High
Anxiety Disorder 200 99.44 Very High Very High Very High
Shock 46 96.48 Very High Very High Very High
Schizophrenia 3 81.44 Quite High
Post-traumatic Stress Disorder 10 55.68 Quite High
INFLAMMATION 1 13.76 Low Low
Congenital Anomalies 3 7.44 Low Low
Targeted Disruption 23 5.00 Very Low Very Low Very Low
Embryonal Carcinoma 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic treatment with morphine produced an increase in expression of CaMKIV and phosphorylated cAMP response element-binding protein (pCREB) in the CA3 region of the hippocampus, whereas a decrease in CaMKIV and pCREB expression was observed in the caudate putamen.
Negative_regulation (decrease) of Gene_expression (expression) of CaMKIV in caudate putamen associated with hippocampus and morphine
1) Confidence 0.43 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931054 Disease Relevance 0 Pain Relevance 0.57
Post-hoc analysis revealed that, for CaMKIV over-expressed mice, presentation of a tone decreased 7.5-13 Hz power during both conditioning (t = 6.06; p < 0.001) and testing days (t = 6.92; p < 0.001) compared to baseline (Figure 4D).
Negative_regulation (decreased) of Gene_expression (expressed) of CaMKIV
2) Confidence 0.38 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.06 Pain Relevance 0
Interestingly, chronic morphine induced a decrease in protein expression of CaMKIV in the basolateral amygdale and the primary somatosensory cortex without any concomitant changes in pCREB.
Negative_regulation (decrease) of Gene_expression (expression) of CaMKIV in primary somatosensory cortex associated with primary somatosensory cortex and morphine
3) Confidence 0.38 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931054 Disease Relevance 0 Pain Relevance 0.57
Therefore, we chose to accentuate trace fear learning (analogous to the effect of CaMKIV over expression) by reducing the duration of the trace fear interval in order to make the time between shock and tone shorter.
Negative_regulation (effect) of Gene_expression (expression) of CaMKIV associated with shock and anxiety disorder
4) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0.69 Pain Relevance 0
Compared to controls, rAAV mediated dnCaMKIV expression in the Nac significantly reduced the total amount of social behaviour in the social interaction test (Student's t-test, p = 0.03).
Negative_regulation (reduced) of Gene_expression (expression) of dnCaMKIV
5) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.50 Pain Relevance 0.10
Interestingly, this change reduced the CaMK IV responses of both the 175CA10-X and 175PR1-X exons compared to their original sequences.
Negative_regulation (reduced) of Gene_expression (responses) of CaMK IV
6) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0 Pain Relevance 0
Point mutations (M1 and M2) within this CaRRE-like sequence led to significant decreases in CaMK IV repression (Figure 3C, lanes 7–10).
Negative_regulation (decreases) of Gene_expression (repression) of CaMK IV associated with repression
7) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.39 Pain Relevance 0
However, co-expression of this clone with CaMK IV strongly repressed exon inclusion (Figure 4A, lanes 3 and 4).
Negative_regulation (repressed) of Gene_expression (expression) of CaMK IV
8) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.44 Pain Relevance 0
Overexpression of CaMK IV reduced the splicing to 10% (Figure 4C, lanes 5 and 6).
Negative_regulation (reduced) of Gene_expression (Overexpression) of CaMK IV
9) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.37 Pain Relevance 0
Results indicated that repeated treatment with haloperidol, clozapine or risperidone increased CaM protein and CaMII mRNA levels but decreased calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) IV (CaMKIV), kinase alpha (CaMKKalpha), kinase beta (CaMKKbeta) and calcineurin protein levels in the striatum of Sprague-Dawley rats (Rattus Norvegicus).
Negative_regulation (decreased) of Gene_expression (levels) of CaMKIV in striatum
10) Confidence 0.07 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.21 Pain Relevance 0.07

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