INT12751

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 11
Speculated 4
Reported most in Abstract
Documents 91
Total Number 96
Disease Relevance 22.42
Pain Relevance 29.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
spinal cord 5
hippocampus 5
brain 4
striatum 3
kidney 2
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 136 100.00 Very High Very High Very High
Enkephalin 109 100.00 Very High Very High Very High
Hippocampus 111 99.84 Very High Very High Very High
Hyperalgesia 134 99.68 Very High Very High Very High
dexamethasone 62 99.60 Very High Very High Very High
Dorsal horn 120 99.48 Very High Very High Very High
Rostral ventrolateral medulla 10 99.44 Very High Very High Very High
amygdala 6 99.36 Very High Very High Very High
medulla 6 99.36 Very High Very High Very High
Morphine 38 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arterial-venous Cerebral Malformations 1 100.00 Very High Very High Very High
Generalized Anxiety Disorder 5 99.78 Very High Very High Very High
Hyperalgesia 134 99.68 Very High Very High Very High
Epilepsy 3 99.66 Very High Very High Very High
Diabetes Mellitus 64 99.42 Very High Very High Very High
Stress 138 99.36 Very High Very High Very High
Eating Disorder 4 99.16 Very High Very High Very High
Hypertension 25 99.12 Very High Very High Very High
Injury 83 98.88 Very High Very High Very High
Frailty 25 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moderate expression was found in testis, while a little OFQ precusor mRNA could be detected in atrium.
Neg (little) Gene_expression (detected) of OFQ precusor mRNA in testis
1) Confidence 0.58 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.31 Pain Relevance 0.20
The present study was designed to investigate the peripheral tissue distribution of OFQ precusor mRNA in stroke-prone spontaneously hypertensive rats (SHRSP) and compare the difference of OFQ precusor mRNA expression in aorta or cultured vascular smooth muscle cells (VSMCs) between SHRSP and wistar-Kyoto normotensive (WKY) rats.
Gene_expression (expression) of OFQ precusor mRNA in smooth muscle cells associated with stroke and hypertension
2) Confidence 0.58 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.35 Pain Relevance 0.24
In the vascular system, OFQ precusor mRNA was expressed in aorta, pulmonary artery, renal artery and vein at high levels comparable with the amounts found in brain.
Gene_expression (expressed) of OFQ precusor mRNA in vein
3) Confidence 0.58 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.30 Pain Relevance 0.18
All other peripheral tissues examined from SHRSP, including ventricle, liver, lung and kidney, showed no expression of OFQ precusor mRNA.
Neg (no) Gene_expression (expression) of OFQ precusor mRNA in liver
4) Confidence 0.58 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.30 Pain Relevance 0.19
Food restriction and diabetes both markedly increased the levels of Prodyn mRNA in the central amygdala (163% and 93%, respectively).
Gene_expression (levels) of Prodyn mRNA in amygdala associated with diabetes mellitus, amygdala and eating disorder
5) Confidence 0.50 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191075 Disease Relevance 0.63 Pain Relevance 0.36
In conclusion, the present study has shown that OFQ precusor mRNA is present in some peripheral tissues, especially in cardiovascular and reproductive system, suggesting that OFQ possibly involves in the regulation of cardiovascular and reproductive functions.
Gene_expression (present) of OFQ precusor mRNA in reproductive system
6) Confidence 0.50 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.27 Pain Relevance 0.06
By using quantitative reverse transcription-polymerase chain reaction (RT-PCR), OFQ precusor mRNA was detected in aorta and ovary at high levels comparable with the amounts found in brain.
Gene_expression (detected) of OFQ precusor mRNA in brain
7) Confidence 0.45 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.33 Pain Relevance 0.22
These data indicate that the PPEnk mRNA is expressed in a certain discrete subpopulation of cells in the rat pineal gland and these cells are not serotonin-producing pinealocytes. 4.
Gene_expression (expressed) of PPEnk mRNA in pinealocytes associated with serotonin
8) Confidence 0.37 Published 1996 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8714561 Disease Relevance 0 Pain Relevance 0.22
Approximately 7% of the cells in the pineal gland (7.5 +/- 0.86, mean +/- 95% CI) express PPEnk mRNA.
Gene_expression (express) of PPEnk mRNA in pineal gland
9) Confidence 0.37 Published 1996 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8714561 Disease Relevance 0 Pain Relevance 0.18
Additionally, dexamethasone did not affect the expression of proDYN mRNA level induced by forskolin.
Gene_expression (expression) of proDYN mRNA associated with dexamethasone
10) Confidence 0.36 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.41
The effect of deep prepyriform cortex (DPC) kindling on the levels of prodynorphin mRNA (DYN mRNA) in rat hippocampus and striatum was examined under two different stimulation paradigms.
Gene_expression (levels) of DYN mRNA in striatum associated with hippocampus
11) Confidence 0.34 Published 1989 Journal Brain Res. Section Abstract Doc Link 2776033 Disease Relevance 0.15 Pain Relevance 0.12
Sorting by flow cytometry of cycloheximide-treated cells followed by in situ hybridization analysis revealed that the expression of PEA mRNA was exclusively confined to a small fraction of B cells.
Gene_expression (expression) of mRNA in B cells
12) Confidence 0.30 Published 1991 Journal Endocrinology Section Abstract Doc Link 1855463 Disease Relevance 0 Pain Relevance 0.11
Furthermore, the striatal levels of preprocholecystokinin mRNA showed marked individual variations during the early period of postnatal development.
Gene_expression (levels) of preprocholecystokinin mRNA
13) Confidence 0.25 Published 1988 Journal Brain Res. Section Abstract Doc Link 3219577 Disease Relevance 0.09 Pain Relevance 0.09
All other peripheral tissues examined from SHRSP, including ventricle, liver, lung and kidney, showed no expression of OFQ precusor mRNA.
Neg (no) Gene_expression (expression) of OFQ precusor mRNA in kidney
14) Confidence 0.20 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.30 Pain Relevance 0.19
In the vascular system, OFQ precusor mRNA was expressed in aorta, pulmonary artery, renal artery and vein at high levels comparable with the amounts found in brain.
Gene_expression (expressed) of OFQ precusor mRNA in pulmonary artery
15) Confidence 0.20 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.30 Pain Relevance 0.18
All other peripheral tissues examined from SHRSP, including ventricle, liver, lung and kidney, showed no expression of OFQ precusor mRNA.
Neg (no) Gene_expression (expression) of OFQ precusor mRNA in ventricle
16) Confidence 0.20 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.30 Pain Relevance 0.19
In the vascular system, OFQ precusor mRNA was expressed in aorta, pulmonary artery, renal artery and vein at high levels comparable with the amounts found in brain.
Gene_expression (expressed) of OFQ precusor mRNA in aorta
17) Confidence 0.20 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.30 Pain Relevance 0.18
All other peripheral tissues examined from SHRSP, including ventricle, liver, lung and kidney, showed no expression of OFQ precusor mRNA.
Neg (no) Gene_expression (expression) of OFQ precusor mRNA in lung
18) Confidence 0.20 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.30 Pain Relevance 0.19
In the vascular system, OFQ precusor mRNA was expressed in aorta, pulmonary artery, renal artery and vein at high levels comparable with the amounts found in brain.
Gene_expression (expressed) of OFQ precusor mRNA in renal artery
19) Confidence 0.20 Published 1999 Journal Chin. Med. Sci. J. Section Abstract Doc Link 12901610 Disease Relevance 0.30 Pain Relevance 0.18
PPENK mRNA is detected in developing ganglia beginning at postnatal days 4-7.
Gene_expression (detected) of PPENK mRNA in ganglia
20) Confidence 0.16 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7700580 Disease Relevance 0.25 Pain Relevance 0.16

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