INT127553

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.87
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pcsk1) extracellular space (Pcsk1) embryo development (Pcsk1)
Anatomy Link Frequency
chondrocytes 1
Pcsk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 144 99.46 Very High Very High Very High
Spinal cord 3 68.00 Quite High
Kinase C 42 49.44 Quite Low
Enkephalin 3 25.00 Low Low
Central nervous system 1 14.08 Low Low
ischemia 3 5.60 Low Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 97 93.04 High High
Death 80 91.84 High High
Brain Injury 1 7.68 Low Low
Cv Unclassified Under Development 1 5.60 Low Low
Chondrocalcinosis 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 11 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro assays have demonstrated that peptides derived from the recently-identified proSAAS precursor inhibit prohormone convertase 1 (PC1) suggesting that this novel peptide may function as an endogenous inhibitor of PC1.
Negative_regulation (inhibit) of prohormone convertase 1
1) Confidence 0.40 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935061 Disease Relevance 0 Pain Relevance 0.03
In vitro assays have demonstrated that peptides derived from the recently-identified proSAAS precursor inhibit prohormone convertase 1 (PC1) suggesting that this novel peptide may function as an endogenous inhibitor of PC1.
Negative_regulation (inhibit) of PC1
2) Confidence 0.40 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935061 Disease Relevance 0 Pain Relevance 0.03
In vitro assays have demonstrated that peptides derived from the recently-identified proSAAS precursor inhibit prohormone convertase 1 (PC1) suggesting that this novel peptide may function as an endogenous inhibitor of PC1.
Negative_regulation (inhibitor) of PC1
3) Confidence 0.40 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935061 Disease Relevance 0 Pain Relevance 0.03
When ePPi levels were measured in culture supernatant of chondrocytes transfected with siRNA, inhibition of PC-1 was ineffective on basal ePPi level and accounted for only a 16% decrease in ePPi level in TGF-?
Negative_regulation (inhibition) of PC-1 in chondrocytes
4) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
Thus, calpain inhibition specifically protects against glutamate-induced production of 145 BDP and caspase-3 inhibition inhibits production of 120 BDP.
Negative_regulation (inhibition) of BDP associated with glutamate
5) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.87 Pain Relevance 0.23

General Comments

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