INT127555

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 59
Total Number 69
Disease Relevance 50.20
Pain Relevance 8.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
spike 6
adult brain 2
brain 2
hippocampus 2
nerve 2
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 14 99.70 Very High Very High Very High
ischemia 198 99.62 Very High Very High Very High
Hippocampus 337 99.56 Very High Very High Very High
Central nervous system 59 99.32 Very High Very High Very High
medulla 110 99.28 Very High Very High Very High
Neuronal excitability 935 98.92 Very High Very High Very High
Eae 6 98.00 Very High Very High Very High
qutenza 9 97.64 Very High Very High Very High
antagonist 276 95.12 Very High Very High Very High
addiction 55 94.48 High High
Disease Link Frequency Relevance Heat
Convulsion 3740 99.92 Very High Very High Very High
Epilepsy 881 99.84 Very High Very High Very High
Apoptosis 165 99.68 Very High Very High Very High
Transient Ischemic Attack 8 99.62 Very High Very High Very High
Targeted Disruption 4240 99.48 Very High Very High Very High
Stroke 220 99.12 Very High Very High Very High
Death 468 98.64 Very High Very High Very High
Neurological Disease 57 98.40 Very High Very High Very High
Anaerobic Bacterial Infections 440 97.68 Very High Very High Very High
Cv Unclassified Under Development 114 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner.
Negative_regulation (inhibitor) of Cdk5 associated with qutenza and cough
1) Confidence 0.59 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17459370 Disease Relevance 0.49 Pain Relevance 0.55
Although short-term loss of Cdk5 produced enhancements in plasticity and learning [7], it is possible that chronic loss of Cdk5 and the associated epileptiform activity leads to neurodegeneration and impaired synaptogenesis, learning, and structural plasticity [5], [16].


Negative_regulation (loss) of Cdk5
2) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.43 Pain Relevance 0.15
Audiogenic behavioral seizures after chronic loss of Cdk5
Negative_regulation (loss) of Cdk5 associated with epilepsy
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.03 Pain Relevance 0.07
These findings indicate that loss of Cdk5 led to increased Mg2+-sensitive post-synaptic potentials suggesting increased NMDAR function.


Negative_regulation (loss) of Cdk5
4) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.51 Pain Relevance 0.18
There may be common mechanistic features between loss of Cdk5 and diversion of Cdk5 to form a complex with p25.
Negative_regulation (loss) of Cdk5
5) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.56 Pain Relevance 0.11
Although the experiments were performed at varying time-points after Cdk5 KO, together, the results suggest that loss of Cdk5 leads to a progressive increase in neuronal and behavioral excitability, ultimately leading to seizures.
Negative_regulation (loss) of Cdk5 in neuronal associated with targeted disruption and convulsion
6) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.66 Pain Relevance 0.06
Given that loss of Cdk5 led to increases in acoustic startle reactivity, we examined whether loss of Cdk5 reduced the susceptibility to audiogenic seizures.
Spec (whether) Negative_regulation (loss) of Cdk5 associated with epilepsy
7) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.32 Pain Relevance 0.05
Conditional loss of Cdk5 leads to elevated Mg2+-sensitive potentials
Negative_regulation (loss) of Cdk5
8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.63 Pain Relevance 0.15
For example, loss of Cdk5 led to a subtle impairment in fEPSP repolarization in the hippocampal SC/CA1 pathway.
Negative_regulation (loss) of Cdk5
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.43 Pain Relevance 0.09
In contrast, prolonged loss of Cdk5 (for 8 weeks) increased susceptibility to audiogenically-induced seizures.
Negative_regulation (loss) of Cdk5 associated with convulsion
10) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.57 Pain Relevance 0.07
Increased behavioral seizure susceptibility follows chronic loss of Cdk5
Negative_regulation (loss) of Cdk5 associated with epilepsy
11) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.74 Pain Relevance 0.14
Chronic loss of Cdk5 led to increase central nervous system excitability exhibited by the decreased threshold for chemically-induced seizures.
Negative_regulation (loss) of Cdk5 in central nervous system associated with convulsion and central nervous system
12) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.36 Pain Relevance 0.05
We examined whether conditional loss of Cdk5 increased susceptibility to in vitro epileptiform activity in the SC/CA1 pathway after unmasking NMDARs.
Spec (whether) Negative_regulation (loss) of Cdk5
13) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.47 Pain Relevance 0.12
The chronic KO group consisted of animals 8 weeks following Cdk5 loss.
Negative_regulation (loss) of Cdk5 associated with targeted disruption
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.11 Pain Relevance 0
In the presence of NMDA antagonism these data show no detectable aberration in the presynaptic reserve vesicle pool due to Cdk5 loss.


Negative_regulation (loss) of Cdk5 in vesicle
15) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.74 Pain Relevance 0.17
On the other hand, chronic loss of Cdk5 led to handling-induced head nodding, wet dog shakes, or clonus behavioral seizures in 80% of mice after 8 weeks of Cdk5 KO (Figure 5A, top; Table 1).
Negative_regulation (loss) of Cdk5 in head associated with targeted disruption and epilepsy
16) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.21 Pain Relevance 0
Chronic loss of Cdk5 is associated with both seizures and reduced levels of p25.
Negative_regulation (loss) of Cdk5 associated with convulsion
17) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.32 Pain Relevance 0.17
Conditional loss of Cdk5 led to an enhancement in PTP following a either a 100 Hz tetanus (Figure 2C) or TBS [7].
Negative_regulation (loss) of Cdk5 associated with anaerobic bacterial infections
18) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.74 Pain Relevance 0.20
Conditional loss of Cdk5 improved performance in several hippocampal learning tasks and reduced the threshold for LTP induction.
Negative_regulation (loss) of Cdk5
19) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.34 Pain Relevance 0.13
During the detailed LTP analyses, we find that loss of Cdk5 also leads to an NMDAR-independent enhancement in PTP, a presynaptic form of short-term plasticity.
Negative_regulation (loss) of Cdk5
20) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.50 Pain Relevance 0.13

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