INT127556

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 19.60
Pain Relevance 5.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
neurons 7
neuronal 6
cleavage 2
brain 1
cingulate cortex 1
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 32 99.96 Very High Very High Very High
Peripheral nerve injury 16 99.82 Very High Very High Very High
Opioid 8 99.80 Very High Very High Very High
Neuronal excitability 103 99.72 Very High Very High Very High
Nucleus accumbens 22 99.68 Very High Very High Very High
ischemia 234 99.56 Very High Very High Very High
tolerance 12 99.52 Very High Very High Very High
Inflammation 140 99.44 Very High Very High Very High
Morphine 17 98.98 Very High Very High Very High
cocaine 70 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 500 99.96 Very High Very High Very High
Stress 181 99.82 Very High Very High Very High
Nervous System Injury 39 99.82 Very High Very High Very High
Cv Unclassified Under Development 134 99.56 Very High Very High Very High
Brain Hemorrhage 47 99.56 Very High Very High Very High
INFLAMMATION 171 99.44 Very High Very High Very High
Neuroblastoma 4 99.40 Very High Very High Very High
Shock 65 99.32 Very High Very High Very High
Drug Induced Neurotoxicity 30 99.28 Very High Very High Very High
Disease 850 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the induction and/or activation of cdk5 are implicated in the development of psychological dependence on morphine.
Positive_regulation (activation) of cdk5 associated with psychological dependence and morphine
1) Confidence 0.70 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935062 Disease Relevance 0.27 Pain Relevance 0.68
The level of phosphorylated-cdk5 was significantly increased in the cingulate cortex of mice showing the morphine-induced rewarding effect.
Positive_regulation (increased) of cdk5 in cingulate cortex associated with morphine
2) Confidence 0.70 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15935062 Disease Relevance 0.14 Pain Relevance 0.52
Moreover a differential nociceptive response after chronic morphine exposure in p35(-/-) and Tgp35 mice suggests that Cdk5 activity is important for opioid tolerance.
Positive_regulation (important) of Cdk5 associated with nociception, tolerance, opioid and morphine
3) Confidence 0.69 Published 2006 Journal Cell Cycle Section Abstract Doc Link 16552189 Disease Relevance 0.84 Pain Relevance 0.80
The findings suggest that both pharmacologically- and electrically-induced epileptiform activity results in accumulation of the Cdk5 activating cofactor, p25.


Positive_regulation (accumulation) of Cdk5
4) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.38 Pain Relevance 0.24
Enhanced CDK-5 activity and expression of p35 are associated with differentiation of cultured neuronal cells as well as accelerated neurite outgrowth [4].
Positive_regulation (Enhanced) of CDK-5 in neuronal
5) Confidence 0.66 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.24 Pain Relevance 0.03
Our data revealed a significant transient increase of CDK5 activity in the lesioned ipsilateral hemisphere 3 hrs after the onset of pMCAo, compared to CDK5 activity of the control contralateral hemisphere (Figure 4A).
Positive_regulation (increase) of CDK5
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.19 Pain Relevance 0.05
CDK5 activity is enhanced following focal cerebral ischemia and constitutes an in vivo target of (S)-roscovitine
Positive_regulation (enhanced) of CDK5 associated with brain hemorrhage and ischemia
7) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.19 Pain Relevance 0.05
These data suggested that pMCAo induced cleavage of p35 to p25, with subsequent activation of CDK5/p25 activity.
Positive_regulation (activation) of CDK5 in cleavage
8) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.16 Pain Relevance 0.04
We confirmed that CDK5/p25 activity is increased in the ischemic cerebral tissue as previously described [19], [21], [36].
Positive_regulation (increased) of CDK5
9) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.38 Pain Relevance 0.12
Cyclin-dependent kinase 5 (Cdk5) is predominantly active in postmitotic neurons.
Positive_regulation (active) of Cyclin-dependent kinase 5 in neurons
10) Confidence 0.50 Published 2006 Journal Cell Cycle Section Abstract Doc Link 16552189 Disease Relevance 0.14 Pain Relevance 0.10
Cyclin-dependent kinase 5 (Cdk5) is predominantly active in postmitotic neurons.
Positive_regulation (active) of Cdk5 in neurons
11) Confidence 0.50 Published 2006 Journal Cell Cycle Section Abstract Doc Link 16552189 Disease Relevance 0.14 Pain Relevance 0.10
However, since loss of Cdk5 only conferred a PPF deficit at a very short interstimulus interval, additional information is necessary to better elucidate Cdk5?
Positive_regulation (elucidate) of Cdk5
12) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.37 Pain Relevance 0.04
Although several studies implicate Cdk5 in vesicle release and recycling [41]–[43], [48], the exact nature of Cdk5?
Spec (implicate) Positive_regulation (implicate) of Cdk5 in vesicle
13) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.35 Pain Relevance 0.04
Although the increase in NMDAR-mediated current in Cdk5 KO mice [7] likely contributes to the neuronal hyperexcitability, additional mechanisms are also possible.
Positive_regulation (increase) of Cdk5 in neuronal associated with targeted disruption and hyperexcitability
14) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.46 Pain Relevance 0.18
Studies implicating Cdk5 and p25 in neuronal excitability suggest that Cdk5 may be activated in order to either attenuate or modulate excitability during seizures.
Positive_regulation (activated) of Cdk5 in neuronal associated with convulsion and neuronal excitability
15) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.24 Pain Relevance 0.25
In this study we show that chemically-induced status epilepticus and electroconvulsive shock in healthy animals induced acute generation of a Cdk5-activating cofactor, p25.
Positive_regulation (generation) of Cdk5 associated with shock and status epilepticus
16) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.39 Pain Relevance 0.16
Based on the previous reports describing the role of CDK-5 in nerve regeneration [5] and effect of ASA on CDK-5 [6] it may be assumed that ASA promotes nerve regeneration following peripheral nerve injury through activation of CDK-5.
Positive_regulation (activation) of CDK-5 in peripheral nerve associated with nervous system injury and peripheral nerve injury
17) Confidence 0.44 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.64 Pain Relevance 0.21
Anti-inflammatory drug acetyl salicylic acid elevates CDK-5 and reduces ischemia – reperfusion injury in cultured neurons.
Positive_regulation (elevates) of CDK-5 in neurons associated with reperfusion injury, inflammation and ischemia
18) Confidence 0.44 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC1802865 Disease Relevance 0.36 Pain Relevance 0.22
The p25 fragment triggers CDK5 hyperactivation and translocation of the p25/CDK5 complex to the cytoplasm where it hyperphosphorylates a number of substrates, leading to neuronal death [13].
Positive_regulation (hyperactivation) of CDK5 in neuronal associated with death
19) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.90 Pain Relevance 0.20
The p25 fragment triggers CDK5 hyperactivation and translocation of the p25/CDK5 complex to the cytoplasm where it hyperphosphorylates a number of substrates, leading to neuronal death [13].
Positive_regulation (hyperactivation) of CDK5 in neuronal associated with death
20) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.89 Pain Relevance 0.20

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