INT127565

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 11.67
Pain Relevance 11.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (ENC1) nucleus (ENC1) cytoplasm (ENC1)
Anatomy Link Frequency
cortex 3
gray matter 2
anterior 2
cingulate cortex 1
insula 1
ENC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatosensory cortex 64 100.00 Very High Very High Very High
primary somatosensory cortex 32 100.00 Very High Very High Very High
Transcranial magnetic stimulation 1 100.00 Very High Very High Very High
insula 120 99.92 Very High Very High Very High
Thalamus 64 99.72 Very High Very High Very High
tolerance 9 99.56 Very High Very High Very High
Anterior cingulate cortex 104 98.96 Very High Very High Very High
Pain 321 98.28 Very High Very High Very High
reflex sympathetic dystrophy 56 98.00 Very High Very High Very High
Fibrositis 88 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 32 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 8 99.12 Very High Very High Very High
Pain 721 98.28 Very High Very High Very High
Complex Regional Pain Syndromes 56 98.00 Very High Very High Very High
Sleep Disorders 96 96.84 Very High Very High Very High
Hyperalgesia 8 96.36 Very High Very High Very High
Somatoform Disorder 24 91.04 High High
Low Back Pain 56 87.84 High High
Fibromyalgia 8 82.40 Quite High
Affective Disorder 24 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex increases tolerance to human experimental pain.
Positive_regulation (stimulation) of prefrontal cortex in cortex associated with pain, transcranial magnetic stimulation and tolerance
1) Confidence 0.39 Published 2005 Journal Brain Res Cogn Brain Res Section Title Doc Link 15935625 Disease Relevance 0.55 Pain Relevance 0.89
In addition, Teutsch et al. [47] observed a number of modulations, including an increase in gray matter in the middle cingulate cortex and somatosensory cortex when noxious stimuli were applied repetitively to healthy subjects.
Positive_regulation (increase) of cortex in gray matter associated with somatosensory cortex
2) Confidence 0.04 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 0.56 Pain Relevance 0.99
Maihöfner et al. [26] observed activations in the S1 and S2 cortex, insula, PFC, and in the ACC during pin-prick stimulation of CRPS patients who experience hyperalgesia.
Positive_regulation (activations) of cortex in insula associated with somatosensory cortex, hyperalgesia, primary somatosensory cortex, reflex sympathetic dystrophy, insula and anterior cingulate cortex
3) Confidence 0.04 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.53 Pain Relevance 1.96
The areas of the anterior and mid-cingulate cortex, middle frontal cortex, SMA, thalamus, anterior insula, and basal ganglia displayed more activity in fibromyalgia patients [21,22].
Positive_regulation (cingulate) of cortex in anterior associated with insula, urological neuroanatomy, thalamus and fibrositis
4) Confidence 0.04 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.82 Pain Relevance 1.31
According to the latest research, predictions of pain and perceptions of pain both have a meaningful positive correlation with hyperactivity in the brain areas of the motor cortex and cingulate cortex; the patient group in this line of research showed distinct activity in the frontal and temporal areas [19].
Positive_regulation (cingulate) of cortex in cortex associated with pain and attention deficit hyperactivity disorder
5) Confidence 0.04 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.68 Pain Relevance 1.21
The areas of the anterior and mid-cingulate cortex, middle frontal cortex, SMA, thalamus, anterior insula, and basal ganglia displayed more activity in fibromyalgia patients [21,22].
Positive_regulation (cingulate) of cortex in anterior associated with insula, urological neuroanatomy, thalamus and fibrositis
6) Confidence 0.04 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.76 Pain Relevance 1.30
In addition, Teutsch et al. [47] observed a number of modulations, including an increase in gray matter in the middle cingulate cortex and somatosensory cortex when noxious stimuli were applied repetitively to healthy subjects.
Positive_regulation (increase) of cortex in gray matter associated with somatosensory cortex
7) Confidence 0.04 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 0.55 Pain Relevance 0.98
Maihöfner et al. [26] observed activations in the S1 and S2 cortex, insula, PFC, and in the ACC during pin-prick stimulation of CRPS patients who experience hyperalgesia.
Positive_regulation (activations) of cortex in cortex associated with somatosensory cortex, hyperalgesia, primary somatosensory cortex, reflex sympathetic dystrophy, insula and anterior cingulate cortex
8) Confidence 0.01 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.53 Pain Relevance 1.96
According to the latest research, predictions of pain and perceptions of pain both have a meaningful positive correlation with hyperactivity in the brain areas of the motor cortex and cingulate cortex; the patient group in this line of research showed distinct activity in the frontal and temporal areas [19].
Positive_regulation (cingulate) of cortex in cingulate cortex associated with pain and attention deficit hyperactivity disorder
9) Confidence 0.01 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.68 Pain Relevance 1.21

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