INT12757

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 2.27
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
neuronal 4
striatum 3
hippocampus 3
NAC 2
cholinergic neurons 2
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 9 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
tetrodotoxin 20 99.98 Very High Very High Very High
medulla 4 99.96 Very High Very High Very High
Dopamine 20 99.84 Very High Very High Very High
gABA 6 99.80 Very High Very High Very High
Hippocampus 33 99.52 Very High Very High Very High
antagonist 14 99.48 Very High Very High Very High
Nucleus accumbens 17 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 9 98.24 Very High Very High Very High
Diabetes Mellitus 2 95.40 Very High Very High Very High
Diabetic Nephropathy 3 88.68 High High
Increased Venous Pressure Under Development 1 87.04 High High
Cognitive Disorder 8 85.76 High High
Paralysis 1 84.40 Quite High
Vomiting 1 68.64 Quite High
Headache 1 68.20 Quite High
Dizziness 1 66.96 Quite High
Sleep Disorders 1 66.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTX injected in the caudal ventrolateral medulla (CVLM) inhibited the phenylephrine-induced increase of ACh release.
Negative_regulation (inhibited) of Positive_regulation (increase) of ACh in medulla associated with medulla and tetrodotoxin
1) Confidence 0.42 Published 1998 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 9533616 Disease Relevance 0.08 Pain Relevance 0.94
The elevation of Ach levels by LY163502 is reversed by dopamine antagonists haloperidol, cis-flupenthixol and metoclopramide.
Negative_regulation (reversed) of Positive_regulation (elevation) of Ach associated with dopamine and antagonist
2) Confidence 0.41 Published 1986 Journal Life Sci. Section Abstract Doc Link 3753738 Disease Relevance 0 Pain Relevance 0.62
The possibility that the lesion non-specifically damaged striatal cells on which the agonists, but not the antagonists acted was excluded by results showing, firstly, that the increase in striatal ACh elicited by the ACh precursor, choline, was not blocked by decortication, and secondly, that the degeneration of the corticostriatal neurons did not prevent the ACh-increasing effect of bromocriptine, a long-acting ergot alkaloid, when sufficient time was allowed for the drug to act.
Negative_regulation (blocked) of Positive_regulation (increase) of ACh in ergot associated with antagonist and agonist
3) Confidence 0.37 Published 1986 Journal Brain Res. Section Abstract Doc Link 3004639 Disease Relevance 0.05 Pain Relevance 0.40
The NK1 receptor antagonist, CP 96,345 (10 microM), which by itself had no effect on extracellular ACh, prevented the substance P-induced increase in extracellular ACh.
Negative_regulation (prevented) of Positive_regulation (increase) of ACh associated with antagonist and substance p
4) Confidence 0.35 Published 1993 Journal Brain Res. Section Abstract Doc Link 7693302 Disease Relevance 0 Pain Relevance 0.47
GabaA-stimulated ACh release may be prevented in situ by normal tonic dopaminergic and muscarinic input to cholinergic neurons.
Negative_regulation (prevented) of Positive_regulation (GabaA-stimulated) of GabaA-stimulated ACh in cholinergic neurons
5) Confidence 0.28 Published 1998 Journal Brain Res. Section Abstract Doc Link 9473575 Disease Relevance 0 Pain Relevance 0.18
Superfusion with the inhibitor of neuronal NO synthase, NS 2028 also diminished stimulation-evoked ACh release.
Negative_regulation (diminished) of Positive_regulation (stimulation-evoked) of ACh in neuronal
6) Confidence 0.26 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683902 Disease Relevance 0 Pain Relevance 0.58
Exposure to HBH led to impairment in relearning ability and memory retrieval and it was accompanied by decrease in ACh level and increase in AChE and led to morphological damage.
Negative_regulation (decrease) of Positive_regulation (increase) of ACh associated with hypoxia
7) Confidence 0.24 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19446892 Disease Relevance 1.29 Pain Relevance 0.15
Tetrodotoxin blocked the increase in the release and synthesis of ACh induced by tityustoxin.
Negative_regulation (blocked) of Positive_regulation (induced) of ACh associated with tetrodotoxin
8) Confidence 0.22 Published 1982 Journal Toxicon Section Abstract Doc Link 6808708 Disease Relevance 0 Pain Relevance 0.28
Local administration of the QUIS (100 microM) through the microdialysis fiber implanted in the hippocampus, caused a long lasting increase of extracellular hippocampal ACh level (360%) which was reversed when the drug was withdrawn from the perfusion solution.
Negative_regulation (reversed) of Positive_regulation (increase) of ACh in hippocampus associated with hippocampus
9) Confidence 0.22 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11821149 Disease Relevance 0 Pain Relevance 0.40
Local perfusion with tetrodotoxin (1 microM) decrease the basal release of ACh and prevented the QUIS-induced increase of ACh both in the hippocampus and striatum.
Negative_regulation (prevented) of Positive_regulation (increase) of ACh in striatum associated with tetrodotoxin and hippocampus
10) Confidence 0.22 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11821149 Disease Relevance 0 Pain Relevance 0.38
Tetrodotoxin (TTX; 1 microM), a Na(+) channel blocker, in the perfusion medium, eliminated the clozapine (10 mg/kg)-induced ACh and DA release in the vHIP, indicating their neuronal origin.
Negative_regulation (eliminated) of Positive_regulation (induced) of ACh in neuronal associated with tetrodotoxin and dopamine
11) Confidence 0.21 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364019 Disease Relevance 0.32 Pain Relevance 0.72
TTX blocked S-14 induced Ach in C but failed in STZ-D.
Negative_regulation (blocked) of Neg (failed) Positive_regulation (induced) of Ach associated with tetrodotoxin and somatostatin
12) Confidence 0.09 Published 1991 Journal Funct. Neurol. Section Abstract Doc Link 1743533 Disease Relevance 0.43 Pain Relevance 0.58
The D2 antagonist sulpiride (10 or 100 microM) administered into the NAC via reverse dialysis was ineffective in blocking increases in cortical ACh efflux.
Negative_regulation (blocking) of Positive_regulation (increases) of ACh in NAC associated with nucleus accumbens and antagonist
13) Confidence 0.09 Published 2004 Journal Neuroscience Section Abstract Doc Link 14706776 Disease Relevance 0 Pain Relevance 0.61
Local infusion of tetrodotoxin (1 microM) decreased ACh and GABA basal extracellular levels, and abolished the QUIS-induced increase in ACh and GABA.
Negative_regulation (abolished) of Positive_regulation (increase) of ACh associated with tetrodotoxin and gaba
14) Confidence 0.09 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9535136 Disease Relevance 0 Pain Relevance 0.83
Local perfusion with tetrodotoxin (1 microM) decrease the basal release of ACh and prevented the QUIS-induced increase of ACh both in the hippocampus and striatum.
Negative_regulation (prevented) of in hippocampus Positive_regulation (increase) of ACh in striatum associated with tetrodotoxin and hippocampus
15) Confidence 0.07 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11821149 Disease Relevance 0 Pain Relevance 0.38
Combined perfusion with 5 nM NPY and 10 nM norepinephrine additively inhibited the vasodilator response to PNS but not to exogenous CGRP and ACh.
Negative_regulation (inhibited) of Positive_regulation (response) of ACh associated with calcitonin gene-related peptide
16) Confidence 0.03 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1653537 Disease Relevance 0.09 Pain Relevance 0.74

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