INT127576

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.36
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) cytoplasm (Gal)
Anatomy Link Frequency
nerve 1
Gal (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 2 98.36 Very High Very High Very High
Enkephalin 2 97.68 Very High Very High Very High
Neuropeptide 15 97.32 Very High Very High Very High
Visceral pain 3 96.88 Very High Very High Very High
Neuropathic pain 26 96.72 Very High Very High Very High
gABA 2 96.68 Very High Very High Very High
5HT 1 95.80 Very High Very High Very High
Peripheral nerve injury 1 95.56 Very High Very High Very High
Somatostatin 3 94.96 High High
Dorsal horn 3 94.36 High High
Disease Link Frequency Relevance Heat
Cystitis 3 99.84 Very High Very High Very High
Injury 5 99.36 Very High Very High Very High
Nervous System Injury 35 98.84 Very High Very High Very High
Nociception 11 97.36 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 96.88 Very High Very High Very High
Neuropathic Pain 78 96.72 Very High Very High Very High
Pain 77 91.48 High High
Targeted Disruption 41 90.52 High High
Ganglion Cysts 93 89.80 High High
Demyelinating Disease 1 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following the description of galanin expression increasing after nerve injury, the role of galanin in nociception and neuropathic pain has been the subject of a substantial body of research.
Transcription (description) of galanin in nerve associated with nociception, nervous system injury and neuropathic pain
1) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 1.32 Pain Relevance 0.61
In the present study, we examined the effects of CP-induced cystitis on the levels of mRNAs encoding galanin, corticotropin-releasing hormone (CRH), substance P, and enkephalins in the hypothalamic and limbic nuclei using in situ hybridization histochemistry in mouse.
Transcription (levels) of galanin associated with cystitis, enkephalin and substance p
2) Confidence 0.52 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335920 Disease Relevance 0.47 Pain Relevance 0.62
Outlier values for Gal and Scn11a were also found in two AKR mice (one operated, one sham) and in one operated CBA mouse.
Transcription (found) of Gal
3) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.53 Pain Relevance 0.09
Galanin mRNA levels peaked at proestrus, when expression was 8.7-fold higher than the diestrus levels.
Transcription (levels) of Galanin
4) Confidence 0.47 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15936815 Disease Relevance 0.48 Pain Relevance 0.61
CGRP and ANP mRNAs did not change across the estrous cycle, while expression of galanin and NPY mRNAs were strongly linked to the estrous cycle.
Transcription (expression) of galanin
5) Confidence 0.47 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15936815 Disease Relevance 0.49 Pain Relevance 0.63
Conserved decreases include the transcription factors Hmx1, Runx1 and basonuclin, the peptides galanin and PACAP, as well as advillin and latexin.
Transcription (transcription) of galanin
6) Confidence 0.26 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.80 Pain Relevance 0.47

General Comments

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