INT127591

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.18
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ceacam1) cell adhesion (Ceacam1) plasma membrane (Ceacam1)
Anatomy Link Frequency
epithelial cells 1
external 1
Ceacam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spondylitis 9 98.72 Very High Very High Very High
agonist 15 98.08 Very High Very High Very High
Inflammatory mediators 1 83.60 Quite High
spinal inflammation 3 75.00 Quite High
chemokine 1 74.56 Quite High
Crohn's disease 51 5.16 Low Low
Action potential 36 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 12 98.72 Very High Very High Very High
Pseudomonas Infection 1 97.44 Very High Very High Very High
Adhesions 5 97.16 Very High Very High Very High
Coagulation Disorder 1 96.08 Very High Very High Very High
Sprains And Strains 27 93.08 High High
INFLAMMATION 9 83.20 Quite High
Injury 65 83.12 Quite High
Stress Fractures 12 82.00 Quite High
Bacterial Respiratory Disease 1 76.64 Quite High
Ulcers 1 73.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteocalcin was elevated in 34% of patients, but was not associated with disease activity or BMD.
Osteocalcin Binding (associated) of
1) Confidence 0.35 Published 2005 Journal J. Rheumatol. Section Body Doc Link 15996067 Disease Relevance 0.05 Pain Relevance 0
Furthermore, engagement of CEACAM1 inhibited NK activity in these patients.
CEACAM1 Binding (engagement) of
2) Confidence 0.28 Published 2005 Journal Int. Immunol. Section Abstract Doc Link 15937057 Disease Relevance 1.05 Pain Relevance 0.52
The latter is necessary in order for osteocalcin to bind calcium and bone mineralization to occur.
osteocalcin Binding (bind) of
3) Confidence 0.25 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2235827 Disease Relevance 0.57 Pain Relevance 0
In this manner, membrane bound ecto-ATPases may regulate the type and amount of purinergic agonists that reach the membrane receptors.
ecto-ATPases Binding (bound) of associated with agonist
4) Confidence 0.17 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.10
An externally facing, membrane bound ecto-ATPase has been described in Tetrahymena [50], which can serve to inactivate these purinergic signals.
ecto-ATPase Binding (bound) of
5) Confidence 0.13 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.09
Although we do not define it as a form of chemosensory adaptation, responsiveness to external ATP and GTP is also affected by the presence of externally facing ecto-ATPases which can hydrolyze these compounds and inactivate the depolarizing stimulus.
ecto-ATPases Binding (hydrolyze) of in external
6) Confidence 0.13 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.08
This has been illustrated for neisserial OMVs binding to the CEACAM1 receptor expressed on the surface of T lymphocytes,43 and for OMVs from Pseudomonas aeruginosa fusing with respiratory epithelial cells.44 In the present study, we report that AIEC strain LF82 OMVs can fuse with IECs.
CEACAM1 receptor Binding (binding) of in epithelial cells associated with pseudomonas infection and sprains and strains
7) Confidence 0.00 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.51 Pain Relevance 0

General Comments

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