INT127604

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.61
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CISH) intracellular (CISH) molecular_function (CISH)
cellular_component (CISH)
Anatomy Link Frequency
upper 1
neutrophil 1
CISH (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 99.80 Very High Very High Very High
Multiple sclerosis 67 99.22 Very High Very High Very High
Potency 2 97.92 Very High Very High Very High
headache 16 79.28 Quite High
Cervicogenic headache 14 77.20 Quite High
addiction 6 73.68 Quite High
metalloproteinase 62 71.84 Quite High
tolerance 1 54.88 Quite High
cINOD 3 49.60 Quite Low
cytokine 5 48.24 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 12 100.00 Very High Very High Very High
Demyelinating Disease 70 99.22 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 96.60 Very High Very High Very High
Neutrophil Disorders 4 92.64 High High
Hypersensitivity 2 91.92 High High
Headache 16 79.28 Quite High
Post-traumatic Headache 16 77.20 Quite High
Tics 10 73.76 Quite High
Toxicity 8 59.92 Quite High
Adverse Drug Reaction 35 56.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CIs were recorded in 42.1% of anesthesias: a total of 304 CIs were noted and the frequency of CIs (the number of recorded CIs per anesthesia was 0.84).
Negative_regulation (number) of CIs associated with anesthesia
1) Confidence 0.37 Published 2005 Journal Anesteziol Reanimatol Section Abstract Doc Link 15938093 Disease Relevance 0.09 Pain Relevance 0.10
Two participants with CIS were subsequently diagnosed with MS, and a further four participants with CIS were lost to follow-up (due to moving outside the study area).
Negative_regulation (lost) of CIS associated with multiple sclerosis and syndrome
2) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2966453 Disease Relevance 0.68 Pain Relevance 0.19
The CI can be interpreted moving from the left limit to the right limit of the CIs for 50% improvement at 24 weeks in Table 2.
Negative_regulation (limit) of CIs
3) Confidence 0.12 Published 2010 Journal Chiropr Osteopat Section Body Doc Link PMC2893201 Disease Relevance 0.16 Pain Relevance 0.16
However, in practice, when the upper or the lower limit of NEAR OR or NEAR RR 95% CIs are quite close to 1.0, say 0.95 or 1.05, a wise use of the measure should require “a post hoc” discussion and perhaps a revision of complementary information; a similar situation may arise when considering wide CIs and/or small sample sizes.
Negative_regulation (limit) of CIs in upper
4) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570485 Disease Relevance 0.06 Pain Relevance 0
However, because of the restriction of the methylene bridgehead (cis only) the number of stereoisomers is reduced to eight, i.e. four diastereomeric racemates.
Negative_regulation (reduced) of cis
5) Confidence 0.07 Published 2010 Journal Anal Bioanal Chem Section Body Doc Link PMC2841770 Disease Relevance 0.25 Pain Relevance 0.03
-[3-(4-methoxy-phenyl)propoxy]-4-methoxyphenethyl}-1H-imidazole hydrochloride (SK&F) 96365 and 2-aminoethoxydiphenyl borate (2-APB) remains questionable, N-propargylnitrendipine, MRS1845, represents a promising compound for the development of selective SOCs inhibitors.
Negative_regulation (inhibitors) of SOCs
6) Confidence 0.06 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.09
The correlation between inhibition of depolarization and Ca2+ influx through opened SOCs [174] is supported by experiments in genetically modified neutrophilic cell lines unable to produce superoxide anions but possessing SOCE mechanism.
Negative_regulation (inhibition) of SOCs
7) Confidence 0.06 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.26 Pain Relevance 0
Fatty acids also bind to neutrophil elastase, the parinaric acids, fluorescent-conjugated tetraenoic fatty acids of plant origin, are inhibitors of neutrophil elastase. cis-Parinaric acid (cis-PA) interacts with the enzyme in two inhibitory modes.
Negative_regulation (inhibitors) of cis-PA in neutrophil
8) Confidence 0.01 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.11 Pain Relevance 0.10

General Comments

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