INT127607

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 5.57
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EID1) nucleus (EID1) cell cycle (EID1)
cytoplasm (EID1)
Anatomy Link Frequency
PBL 1
EID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 10 99.24 Very High Very High Very High
Dopamine 14 96.24 Very High Very High Very High
pain flank 1 89.96 High High
peptic ulcer disease 1 85.48 High High
Angina 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 18 100.00 Very High Very High Very High
Cancer 2 99.76 Very High Very High Very High
Idiopathic Thrombocytopenic Purpura 1 99.20 Very High Very High Very High
Metastasis 3 99.08 Very High Very High Very High
Neurodegenerative Disease 4 98.22 Very High Very High Very High
Myeloid Leukemia 3 97.64 Very High Very High Very High
Stroke 2 97.60 Very High Very High Very High
Coronary Artery Disease 2 97.28 Very High Very High Very High
Malignant Neoplastic Disease 3 97.00 Very High Very High Very High
Iron-deficiency Anemia 1 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of two H. pylori proteins, cytotoxin associated protein (cag A) and vacuolization cytotoxin (vac A) is considered to be related with pathogenicity of the bacterium.
Gene_expression (expression) of cytotoxin associated protein
1) Confidence 0.63 Published 2004 Journal Srp Arh Celok Lek Section Abstract Doc Link 15938230 Disease Relevance 2.35 Pain Relevance 0.09
The tumor cells were positive for human melanosome-associated protein (HMB-45) on immunohistochemical staining.
Gene_expression (positive) of melanosome-associated protein associated with cancer
2) Confidence 0.24 Published 2007 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 17493897 Disease Relevance 1.49 Pain Relevance 0.09
Using three independent and established neurodegenerative models in C. elegans, we assayed for acetaminophen-dependent rescue in response to: (1) over-expression of the PD-associated protein, alpha-synuclein; (2) acute exposure to 6-hydroxydopamine (6-OHDA); (3) excess intracellular DA production due to over-expression of the DA biosynthetic enzyme, tyrosine hydroxylase (TH).
Gene_expression (over-expression) of PD-associated protein associated with dopamine, paracetamol, disease and neurodegenerative disease
3) Confidence 0.02 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18514411 Disease Relevance 0.84 Pain Relevance 0.71
CONCLUSION: Our results indicate that PBL isolated from UA patients may be resistant to apoptosis induction by LPC, resulting from oxidative stress challenge and dysregulation of apoptosis-related protein expression.


Gene_expression (expression) of apoptosis-related protein in PBL
4) Confidence 0.02 Published 2007 Journal Atherosclerosis Section Body Doc Link 16564529 Disease Relevance 0.06 Pain Relevance 0
Using three independent and established neurodegenerative models in C. elegans, we assayed for acetaminophen-dependent rescue in response to: (1) over-expression of the PD-associated protein, alpha-synuclein; (2) acute exposure to 6-hydroxydopamine (6-OHDA); (3) excess intracellular DA production due to over-expression of the DA biosynthetic enzyme, tyrosine hydroxylase (TH).
Gene_expression (over-expression) of PD-associated protein associated with dopamine, paracetamol, disease and neurodegenerative disease
5) Confidence 0.02 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18514411 Disease Relevance 0.84 Pain Relevance 0.71

General Comments

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