INT12762

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 8.51
Pain Relevance 8.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 18
hippocampus 4
blood 2
fibroblast 2
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 8 99.88 Very High Very High Very High
narcan 15 99.84 Very High Very High Very High
Morphine 31 99.82 Very High Very High Very High
cva 2 99.82 Very High Very High Very High
tetrodotoxin 2 99.70 Very High Very High Very High
Clonidine 4 99.54 Very High Very High Very High
cytokine 16 99.52 Very High Very High Very High
anesthesia 6 98.68 Very High Very High Very High
antagonist 11 98.36 Very High Very High Very High
Opioid 7 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 27 100.00 Very High Very High Very High
Hypertension 20 100.00 Very High Very High Very High
Cv General 3 Under Development 1 99.82 Very High Very High Very High
Diabetes Mellitus 87 98.44 Very High Very High Very High
Hyperinsulinism 23 98.00 Very High Very High Very High
Hemorrhage 1 97.00 Very High Very High Very High
INFLAMMATION 53 96.68 Very High Very High Very High
Hyperlipidemia 11 95.80 Very High Very High Very High
Neuropathic Pain 10 93.88 High High
Cancer 11 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The morphine induced increase in insulin in the fed rats was abolished by naloxone treatment.
Negative_regulation (abolished) of Positive_regulation (increase) of insulin associated with narcan and morphine
1) Confidence 0.59 Published 1993 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 8140390 Disease Relevance 0.10 Pain Relevance 1.29
These compounds blocked insulin stimulation of IP1 accumulation, suggesting that the action of insulin to stimulate PI turnover is secondary to enhancement of endogenous noradrenergic activity within the hippocampus.
Negative_regulation (blocked) of Positive_regulation (stimulation) of insulin in hippocampus associated with hippocampus
2) Confidence 0.57 Published 1991 Journal Brain Res. Section Abstract Doc Link 1653632 Disease Relevance 0 Pain Relevance 0.38
The increase of plasma insulin and blood glucose-lowering action induced by racecadotril were reduced by pretreatment with atropine and enhanced by physotigmine.
Negative_regulation (reduced) of Positive_regulation (increase) of insulin in plasma
3) Confidence 0.57 Published 2010 Journal Horm. Metab. Res. Section Abstract Doc Link 20143290 Disease Relevance 0.06 Pain Relevance 0.16
Catecholamines, acetylcholine, and enkephalins can be excluded as potential candidates in producing the effects of VLH extract administration, since pretreatment of recipient rats with their respective specific blockers (i.e. phentolamine, propranolol, atropine, and naloxone) did not prevent the increase in plasma insulin levels observed after the injection of VLH extracts.
Negative_regulation (prevent) of Positive_regulation (increase) of insulin in plasma associated with catecholamine, narcan and enkephalin
4) Confidence 0.46 Published 1982 Journal Endocrinology Section Abstract Doc Link 7035144 Disease Relevance 0 Pain Relevance 0.19
The slope of the regression line for glucose disposal rate versus plasma insulin was lower in spontaneously hypertensive rats compared with Wistar-Kyoto rats (2.652 vs. 4.864, P < 0.001), indicating that insulin stimulation of glucose disposal rate was reduced by 50% in spontaneously hypertensive rats.
Negative_regulation (reduced) of Positive_regulation (stimulation) of insulin in plasma associated with hypertension
5) Confidence 0.43 Published 1993 Journal Diabetes Section Abstract Doc Link 8349047 Disease Relevance 0.57 Pain Relevance 0.05
Nosedrops containing both a small amount of alkylglycoside (0.03-0.50%) and insulin (2 U regular porcine) caused a rapid decrease in blood D-glucose levels and a concomitant increase in serum immunoreactive insulin levels.
Negative_regulation (decrease) of Positive_regulation (increase) of insulin in blood
6) Confidence 0.43 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988421 Disease Relevance 0 Pain Relevance 0.14
The addition of clonidine to the drinking water inhibited fructose-induced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructose-fed rats.
Negative_regulation (inhibited) of Positive_regulation (increase) of insulin in plasma associated with hypertension and clonidine
7) Confidence 0.43 Published 1987 Journal Hypertension Section Abstract Doc Link 3311990 Disease Relevance 0.71 Pain Relevance 0.10
At 4-h postblockade a 125-250% increase in peripheral plasma insulin levels occurred due to a combination of enhanced pancreatic insulin secretion and depressed hepatic insulin extraction.
Negative_regulation (depressed) of Positive_regulation (increase) of insulin in plasma
8) Confidence 0.42 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 6989267 Disease Relevance 0.17 Pain Relevance 0.13
Addition of tetrodotoxin resulted in a suppression of insulin stimulation of [3H]IP1 release, suggesting that insulin effects may be indirect and mediated via release of an endogenous neuronal transmitter within the hippocampus.
Negative_regulation (suppression) of Positive_regulation (stimulation) of insulin in hippocampus associated with tetrodotoxin and hippocampus
9) Confidence 0.42 Published 1991 Journal Brain Res. Section Abstract Doc Link 1653632 Disease Relevance 0 Pain Relevance 0.48
Furthermore, during both dearterialization and in the immediate reperfusion phase, the arginine-induced increase in plasma insulin levels was impaired (P less than 0.001), whereas the arginine-induced increase in plasma glucagon levels was not significantly affected.
Negative_regulation (impaired) of Positive_regulation (increase) of insulin in plasma
10) Confidence 0.41 Published 1990 Journal Br J Surg Section Abstract Doc Link 2187562 Disease Relevance 0.57 Pain Relevance 0.07
Haemorrhage-induced increases in glucose, glucagon and insulin levels are blocked by naloxone in rats.
Negative_regulation (blocked) of Positive_regulation (increases) of insulin associated with narcan and cva
11) Confidence 0.41 Published 1994 Journal Eur J Surg Section Title Doc Link 7811825 Disease Relevance 0.20 Pain Relevance 0.39
Also, it is proposed that the absence of a compensatory increase in plasma insulin levels may contribute to the generation of a hyperglycemic response after central fluoxetine administration.
Negative_regulation (absence) of Positive_regulation (increase) of insulin in plasma associated with fluoxetine
12) Confidence 0.39 Published 2004 Journal Neuropeptides Section Abstract Doc Link 15223272 Disease Relevance 0.14 Pain Relevance 0.66
Estradiol (10 micrograms/kg,i.m.) significantly blocked the Con A-induced increase in circulating insulin in male rats (101 +/- 17% for controls vs 32 +/- 5.3% for estradiol-treated animals, P < 0.05) while testosterone (10 mg/kg, i.m.) had no similar effect on intact female rats.
Negative_regulation (blocked) of Positive_regulation (increase) of insulin
13) Confidence 0.35 Published 1998 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9698777 Disease Relevance 0.64 Pain Relevance 0.30
The latter regimen also decreased significantly increased plasma levels of insulin and glucose and insulin resistance (HOMA index) at 14 weeks.
Negative_regulation (decreased) of Positive_regulation (increased) of insulin in plasma associated with insulin resistance
14) Confidence 0.34 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17988733 Disease Relevance 1.39 Pain Relevance 0.54
We have recently shown that meal-induced insulin sensitization (MIS) occurs after feeding and decreases progressively to insignificance after 24 h of fasting and is caused by action of a hepatic insulin sensitizing substance (HISS).
Negative_regulation (decreases) of Positive_regulation (meal-induced) of insulin
15) Confidence 0.33 Published 2006 Journal Br. J. Nutr. Section Abstract Doc Link 16469144 Disease Relevance 0 Pain Relevance 0
The latter regimen also decreased significantly increased plasma levels of insulin and glucose and insulin resistance (HOMA index) at 14 weeks.
Negative_regulation (decreased) of Positive_regulation (increased) of insulin in plasma associated with insulin resistance
16) Confidence 0.33 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17988733 Disease Relevance 1.38 Pain Relevance 0.53
When morphine was combined with somatostatin, the increase in glucose, insulin and glucagon was significantly reduced.
Negative_regulation (reduced) of Positive_regulation (increase) of insulin associated with somatostatin and morphine
17) Confidence 0.31 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102765 Disease Relevance 0 Pain Relevance 1.08
The cytokine IL-1 beta caused a significant decrease in both beta-cell mitogenesis and insulin accumulation, effects that were mediated through nitric oxide generation.
Negative_regulation (decrease) of Positive_regulation (accumulation) of insulin associated with cytokine
18) Confidence 0.30 Published 1995 Journal Ups. J. Med. Sci. Section Abstract Doc Link 8808183 Disease Relevance 0.31 Pain Relevance 0.24
Exogenous prostaglandins E2 and F1 alpha were inactive, while the cycloxygenase inhibitor indomethacin slightly suppressed insulin accumulation.
Negative_regulation (suppressed) of Positive_regulation (accumulation) of insulin
19) Confidence 0.30 Published 1995 Journal Ups. J. Med. Sci. Section Abstract Doc Link 8808183 Disease Relevance 0.27 Pain Relevance 0.23
Growth hormone stimulated insulin accumulation and inhibited DNA synthesis, whereas galanin and insulin-like growth factor I caused a moderate suppression of insulin accumulation but did not affect proliferation, while epidermal growth factor, transforming growth factor beta, platelet-derived growth factor, acidic and basic fibroblast growth factor, bradykinin and somatostatin were virtually inactive on all parameters tested.
Negative_regulation (suppression) of Positive_regulation (accumulation) of insulin in fibroblast associated with somatostatin and bradykinin
20) Confidence 0.29 Published 1995 Journal Ups. J. Med. Sci. Section Abstract Doc Link 8808183 Disease Relevance 0.32 Pain Relevance 0.13

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