INT127633
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Another clinical application of K8/K18 is the monitoring of fragments of these keratins in the serum as serological tumor markers to monitor cancer load, cancer progression, and response to therapy. | |||||||||||||||
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For apoptosis detection, the translocation of phosphatidylserine (Annexin V-FITC assay), Apo2.7 and the Caspase activity on cytokeratin 18 were determined by flow cytometry. | |||||||||||||||
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The type I keratin K18 is located in the type II cluster on chromosome 17 (arrow). b Two-dimensional catalog of the human keratin proteins according to molecular weights (MW) and isoelectric points (IEP) as calculated from amino acid sequences. | |||||||||||||||
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During apoptosis, CK18 is cleaved by caspases and released into the extracellular compartment. | |||||||||||||||
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Presence of caspase cleaved CK18 has been shown to be a reliable marker of apoptosis, while release of intact CK18 reflects necrosis.39 Increased levels of caspase-cleaved CK18 have been measured in the serum of breast cancer patients when compared with controls.40 | |||||||||||||||
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IgG immunoblotting for CK8, CK18, and CK19 | |||||||||||||||
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Thus, CK8, CK18, and CK19, which were used in this study, have been found only in simple epithelia, including both bronchial and lung alveolar epithelial cells (17), which are the major target tissues of asthma. | |||||||||||||||
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IgG immunoblotting for CK8, CK18, and CK19 | |||||||||||||||
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General Comments
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