INT127633

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 5.93
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT18) cell cycle (KRT18) microtubule organizing center (KRT18)
cytoplasm (KRT18)
Anatomy Link Frequency
lung 1
KRT18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 38 92.00 High High
lidocaine 6 91.92 High High
chemokine 3 89.52 High High
antagonist 1 88.76 High High
aspirin 132 80.88 Quite High
Paracetamol 3 71.04 Quite High
Chronic pancreatitis 4 36.12 Quite Low
Bile 2 9.20 Low Low
medulla 14 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 59 99.96 Very High Very High Very High
Necrosis 6 99.60 Very High Very High Very High
Cancer 226 98.76 Very High Very High Very High
Breast Cancer 26 96.08 Very High Very High Very High
Asthma 180 94.76 High High
INFLAMMATION 39 92.00 High High
Malignant Neoplastic Disease 20 88.56 High High
Skin Cancer 60 86.48 High High
Metastasis 38 83.36 Quite High
Pancreatic Cancer 94 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another clinical application of K8/K18 is the monitoring of fragments of these keratins in the serum as serological tumor markers to monitor cancer load, cancer progression, and response to therapy.
Localization (application) of K18 associated with cancer
1) Confidence 0.52 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.34 Pain Relevance 0
For apoptosis detection, the translocation of phosphatidylserine (Annexin V-FITC assay), Apo2.7 and the Caspase activity on cytokeratin 18 were determined by flow cytometry.
Spec (determined) Localization (translocation) of cytokeratin 18 associated with apoptosis
2) Confidence 0.52 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942692 Disease Relevance 0.40 Pain Relevance 0.52
The type I keratin K18 is located in the type II cluster on chromosome 17 (arrow). b Two-dimensional catalog of the human keratin proteins according to molecular weights (MW) and isoelectric points (IEP) as calculated from amino acid sequences.
Localization (located) of K18
3) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
During apoptosis, CK18 is cleaved by caspases and released into the extracellular compartment.
Localization (released) of CK18 associated with apoptosis
4) Confidence 0.23 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.48 Pain Relevance 0
Presence of caspase cleaved CK18 has been shown to be a reliable marker of apoptosis, while release of intact CK18 reflects necrosis.39 Increased levels of caspase-cleaved CK18 have been measured in the serum of breast cancer patients when compared with controls.40
Localization (release) of CK18 associated with necrosis, breast cancer and apoptosis
5) Confidence 0.21 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.41 Pain Relevance 0
IgG immunoblotting for CK8, CK18, and CK19
Localization (immunoblotting) of CK18
6) Confidence 0.04 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0 Pain Relevance 0
Thus, CK8, CK18, and CK19, which were used in this study, have been found only in simple epithelia, including both bronchial and lung alveolar epithelial cells (17), which are the major target tissues of asthma.
Localization (found) of CK18 in lung associated with asthma
7) Confidence 0.04 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.89 Pain Relevance 0.19
IgG immunoblotting for CK8, CK18, and CK19
Localization (immunoblotting) of CK18
8) Confidence 0.04 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.42 Pain Relevance 0.04

General Comments

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